Search Results - "Nakayama, Maki"

Insulin as a key autoantigen in the development of type 1 diabetes by Nakayama, Maki

“…Type 1 diabetes is a T‐cell‐mediated autoimmune disease against pancreatic beta cells. T cells target various antigens such as insulin, chromogranin A,…”
Get full text

Using the T Cell Receptor as a Biomarker in Type 1 Diabetes by Nakayama, Maki, Michels, Aaron W

“…T cell receptors (TCRs) are unique markers that define antigen specificity for a given T cell. With the evolution of sequencing and computational analysis…”
Get full text

Hybrid Insulin Peptides Are Autoantigens in Type 1 Diabetes by Baker, Rocky L, Rihanek, Marynette, Hohenstein, Anita C, Nakayama, Maki, Michels, Aaron, Gottlieb, Peter A, Haskins, Kathryn, Delong, Thomas

“…We recently established that hybrid insulin peptides (HIPs) are present in human islets and that T cells reactive to HIPs are found in the residual islets of…”
Get full text

Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish by Ogawa, Masahito, Geng, Fan-Suo, Humphreys, David T, Kristianto, Esther, Sheng, Delicia Z, Hui, Subhra P, Zhang, Yuxi, Sugimoto, Kotaro, Nakayama, Maki, Zheng, Dawei, Hesselson, Daniel, Hodson, Mark P, Bogdanovic, Ozren, Kikuchi, Kazu

“…Cardiac regeneration requires dedifferentiation and proliferation of mature cardiomyocytes, but the mechanisms underlying this plasticity remain unclear. Here,…”
Get full text

The MicroRNA miR-181 Is a Critical Cellular Metabolic Rheostat Essential for NKT Cell Ontogenesis and Lymphocyte Development and Homeostasis by Henao-Mejia, Jorge, Williams, Adam, Goff, Loyal A., Staron, Matthew, Licona-Limón, Paula, Kaech, Susan M., Nakayama, Maki, Rinn, John L., Flavell, Richard A.

“…Regulation of metabolic pathways in the immune system provides a mechanism to actively control cellular function, growth, proliferation, and survival. Here, we…”
Get full text

Specificity and detection of insulin-reactive CD4⁺ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse by Crawford, Frances, Stadinski, Brian, Jin, Niyun, Michels, Aaron, Nakayama, Maki, Pratt, Philip, Marrack, Philippa, Eisenbarth, George, Kappler, John W.

“…In the nonobese diabetic (NOD) mouse model of type 1 diabetes (T1D), an insulin peptide (B:9-23) is a major target for pathogenic CD4⁺ T cells. However, there…”
Get full text

Germline-like TCR-α chains shared between autoreactive T cells in blood and pancreas by Linsley, Peter S., Nakayama, Maki, Balmas, Elisa, Chen, Janice, Barahmand-pour-Whitman, Fariba, Bansal, Shubham, Bottorff, Ty, Serti, Elisavet, Speake, Cate, Pugliese, Alberto, Cerosaletti, Karen

“…Human type 1 diabetes (T1D) is caused by autoimmune attack on the insulin-producing pancreatic beta cells by islet antigen-reactive T cells. How human islet…”
Get full text

Zebrafish FOXP3 is required for the maintenance of immune tolerance by Sugimoto, Kotaro, Hui, Subhra P., Sheng, Delicia Z., Nakayama, Maki, Kikuchi, Kazu

“…Regulatory T (Treg) cells play a central role in the suppression of excessive immune responses against both self and non-self antigens. The development and…”
Get full text

Determining Antigen Specificity of Human Islet Infiltrating T Cells in Type 1 Diabetes by Nakayama, Maki, Michels, Aaron W

“…Type 1 diabetes, the immune mediated form of diabetes, represents a prototypical organ specific autoimmune disease in that insulin producing pancreatic islets…”
Get full text

Characterization of Human CD4 T Cells Specific for a C-Peptide/C-Peptide Hybrid Insulin Peptide by Wiles, Timothy A, Hohenstein, Anita, Landry, Laurie G, Dang, Mylinh, Powell, Roger, Guyer, Perrin, James, Eddie A, Nakayama, Maki, Haskins, Kathryn, Delong, Thomas, Baker, Rocky L

“…Hybrid Insulin Peptides (HIPs), which consist of insulin fragments fused to other peptides from β-cell secretory granule proteins, are CD4 T cell autoantigens…”
Get full text

Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects by Nakayama, Maki, McDaniel, Kristen, Fitzgerald-Miller, Lisa, Carol, Kiekhaefer, Snell-Bergeona, Janet K., Davidson, Howard W., Rewers, Marian, Yu, Liping, Gottlieb, Peter, Kappler, John W., Michels, Aaron

“…Certain class II MHC (MHCII) alleles in mice and humans confer risk for or protection from type 1 diabetes (T1D). Insulin is a major autoantigen in T1D, but…”
Get full text

Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis by Ishigame, Harumichi, Zenewicz, Lauren A., Sanjabi, Shomyseh, Licona-Limón, Paula, Nakayama, Maki, Leonard, Warren J., Flavell, Richard A.

“…TGF-β signaling in T cells is critical for peripheral T-cell tolerance by regulating effector CD4 ⁺ T helper (Th) cell differentiation. However, it is still…”
Get full text

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice by Elliott, John F, Moriyama, Hiroaki, Babaya, Naru, Miao, Dongmei, Eisenbarth, George S, Wegmann, Dale R, Yu, Liping, Liu, Edwin, Hutton, John C, Abiru, Norio, Nakayama, Maki

“…A fundamental question about the pathogenesis of spontaneous autoimmune diabetes is whether there are primary autoantigens. For type 1 diabetes it is clear…”
Get full text

Multiplex T Cell Stimulation Assay Utilizing a T Cell Activation Reporter-Based Detection System by Mann, Sarah E, Zhou, Zhicheng, Landry, Laurie G, Anderson, Amanda M, Alkanani, Aimon K, Fischer, Jeremy, Peakman, Mark, Mallone, Roberto, Campbell, Kristen, Michels, Aaron W, Nakayama, Maki

“…Recent advancements in single cell sequencing technologies allow for identification of numerous immune-receptors expressed by T cells such as tumor-specific…”
Get full text

Insulin B-chain hybrid peptides are agonists for T cells reactive to insulin B:9-23 in autoimmune diabetes by Wenzlau, Janet M, DiLisio, James E, Barbour, Gene, Dang, Mylinh, Hohenstein, Anita C, Nakayama, Maki, Delong, Thomas, Baker, Rocky L, Haskins, Kathryn

“…Insulin is considered to be a key antigenic target of T cells in Type 1 Diabetes (T1D) and autoimmune diabetes in the NOD mouse with particular focus on the…”
Get full text

Monoclonal antibody blocking the recognition of an insulin peptide–MHC complex modulates type 1 diabetes by Li Zhang, Crawford, Frances, Yu, Liping, Michels, Aaron, Nakayama, Maki, Davidson, Howard W., Kappler, John W., Eisenbarth, George S.

“…The primary autoantigen triggering spontaneous type 1 diabetes mellitus in nonobese diabetic (NOD) mice is insulin. The major T-cell insulin epitope lies…”
Get full text

Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors by Landry, Laurie G, Anderson, Amanda M, Russ, Holger A, Yu, Liping, Kent, Sally C, Atkinson, Mark A, Mathews, Clayton E, Michels, Aaron W, Nakayama, Maki

“…Proinsulin is an abundant protein that is selectively expressed by pancreatic beta cells and has been a focus for development of antigen-specific…”
Get full text

High-dose dexamethasone therapy as the initial treatment for idiopathic thrombocytopenic purpura by Takase, Ken, Nagai, Hirokazu, Kadono, Moe, Yoshioka, Takanori, Yoshio, Nobuyuki, Hirabayashi, Yukio, Ito, Takuo, Sawamura, Morio, Yokoyama, Akihiro, Yoshida, Shinichiro, Tsutsumi, Ikuyo, Otsuka, Maki, Suehiro, Youko, Hidaka, Michihiro, Yoshida, Isao, Yokoyama, Hisayuki, Inoue, Hitoshi, Iida, Hiroatsu, Nakayama, Maki, Hishita, Terutoshi, Iwasaki, Hiromi, Kada, Akiko, Saito, Akiko M., Kuroda, Yoshiaki

“…There is a controversy which short term high dose dexamethasone therapy (HDD) or standard dose prednisolone therapy as the initial treatment leads to long term…”
Get full text

In Vitro Selection of Highly Darunavir-Resistant and Replication-Competent HIV-1 Variants by Using a Mixture of Clinical HIV-1 Isolates Resistant to Multiple Conventional Protease Inhibitors by KOH, Yasuhiro, AMANO, Masayuki, TOWATA, Tomomi, DANISH, Matthew, LESHCHENKO-YASHCHUK, Sofiya, DAS, Debananda, NAKAYAMA, Maki, TOJO, Yasushi, GHOSH, Arun K, MITSUYA, Hiroaki

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans by Hanna, Stephanie J, Thayer, Terri C, Robinson, Emma J S, Vinh, Ngoc-Nga, Williams, Nigel, Landry, Laurie G, Andrews, Robert, Siah, Qi Zhuang, Leete, Pia, Wyatt, Rebecca, McAteer, Martina A, Nakayama, Maki, Wong, F Susan, Yang, Jennie H M, Tree, Timothy I M, Ludvigsson, Johnny, Dayan, Colin M, Tatovic, Danijela

“…Gold nanoparticles (GNPs) have been used in the development of novel therapies as a way of delivery of both stimulatory and tolerogenic peptide cargoes. Here…”
Get full text