Search Results - "Nakayama, Kei‐Ichi"

U Box Proteins as a New Family of Ubiquitin-Protein Ligases by Hatakeyama, Shigetsugu, Yada, Masayoshi, Matsumoto, Masaki, Ishida, Noriko, Nakayama, Kei-Ichi

“…The U box is a domain of ∼70 amino acids that is present in proteins from yeast to humans. The prototype U box protein, yeast Ufd2, was identified as a…”
Get full text

CHIP promotes proteasomal degradation of familial ALS‐linked mutant SOD1 by ubiquitinating Hsp/Hsc70 by Urushitani, Makoto, Kurisu, Junko, Tateno, Minako, Hatakeyama, Shigetsugu, Nakayama, Kei‐Ichi, Kato, Shinsuke, Takahashi, Ryosuke

“…Summary Over 100 mutants in superoxide dismutase 1 (SOD1) are reported in familial amyotrophic lateral sclerosis (ALS). However, the precise mechanism by which…”
Get full text

The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs by Rodriguez, Sonia, Wang, Lin, Mumaw, Christen, Srour, Edward F., Lo Celso, Cristina, Nakayama, Kei-ichi, Carlesso, Nadia

“…Exit from quiescence and reentry into cell cycle is essential for HSC self-renewal and regeneration. Skp2 is the F-box unit of the SCF E3-ligase that targets…”
Get full text

Degradation of p27 at the G0-G1 Transition Mediated by a Skp2-independent Ubiquitination Pathway by Hara, Taichi, Kamura, Takumi, Nakayama, Keiko, Oshikawa, Kiyotaka, Hatakeyama, Shigetsugu, Nakayama, Kei-Ichi

Get full text

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice by Takai, H, Tominaga, K, Motoyama, N, Minamishima, Y A, Nagahama, H, Tsukiyama, T, Ikeda, K, Nakayama, K, Nakanishi, M

“…The recent discovery of checkpoint kinases has suggested the conservation of checkpoint mechanisms between yeast and mammals. In yeast, the protein kinase Chk1…”
Get full text

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin by Kitagawa, Masatoshi, Hatakeyama, Shigetsugu, Shirane, Michiko, Matsumoto, Masaki, Ishida, Noriko, Hattori, Kimihiko, Nakamichi, Ikuo, Kikuchi, Akira, Nakayama, Kei-ichi, Nakayama, Keiko

“…β‐catenin plays an essential role in the Wingless/Wnt signaling cascade and is a component of the cadherin cell adhesion complex. Deregulation of β‐catenin…”
Get full text

Cooperative Regulation of the Cell Division Cycle by the Protein Kinases RAF and AKT by Mirza, Amer M., Gysin, Stephan, Malek, Nisar, Nakayama, Kei-ichi, Roberts, James M., McMahon, Martin

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The SOCS Box of SOCS-1 Accelerates Ubiquitin-dependent Proteolysis of TEL-JAK2 by Kamizono, S, Hanada, T, Yasukawa, H, Minoguchi, S, Kato, R, Minoguchi, M, Hattori, K, Hatakeyama, S, Yada, M, Morita, S, Kitamura, T, Kato, H, Nakayama Ki, Yoshimura, A

“…Fusion of the TEL gene on 12p13 to the JAK2 tyrosine kinase gene on 9p24 has been found in human leukemia. TEL -mediated oligomerization of JAK2 results in…”
Get full text

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors by Nakayama, K, Ishida, N, Shirane, M, Inomata, A, Inoue, T, Shishido, N, Horii, I, Loh, D Y, Nakayama, K

“…Mice lacking p27(Kip1) have been created by gene targeting in embryonic stem cells. These mice are larger than the control animals, with thymus, pituitary, and…”
Get full text

Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing by Shirane, M, Harumiya, Y, Ishida, N, Hirai, A, Miyamoto, C, Hatakeyama, S, Nakayama, K, Kitagawa, M

“…The intracellular level of p27(Kip1), a cyclin-dependent kinase (CDK) inhibitory protein, is rapidly reduced at the G1/S transition phase when the cell cycle…”
Get full text

Role of the PLC-related, catalytically inactive protein p130 in GABAA receptor function by Kanematsu, Takashi, Jang, Il-Sung, Yamaguchi, Taku, Nagahama, Hiroyasu, Yoshimura, Kenji, Hidaka, Kiyoshi, Matsuda, Miho, Takeuchi, Hiroshi, Misumi, Yoshio, Nakayama, Keiko, Yamamoto, Tsuneyuki, Akaike, Norio, Hirata, Masato, Nakayama, Kei-Ichi

“…The protein p130 was isolated from rat brain as an inositol 1,4,5‐trisphosphate‐binding protein with a domain organization similar to that of phospholipase…”
Get full text

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x- Deficient Mice by Motoyama, Noboru, Wang, Fanping, Roth, Kevin A., Sawa, Hirofumi, Nakayama, Kei-ichi, Nakayama, Keiko, Negishi, Izumi, Senju, Satoru, Zhang, Qing, Fujii, Satoshi, Loh, Dennis Y.

“…bcl-x is a member of the bcl-2 gene family, which may regulate programmed cell death. Mice were generated that lacked Bcl-x. The Bcl-x-deficient mice died…”
Get full text

The role of Tyk2, Stat1 and Stat4 in LPS-induced endotoxin signals by Kamezaki, Kenjirou, Shimoda, Kazuya, Numata, Akihiko, Matsuda, Tadashi, Nakayama, Kei-Ichi, Harada, Mine

“…Mice lacking Tyk2, Stat1 or Stat4, which are members of the Jak–Stat signaling cascade, were resistant to LPS-induced endotoxin shock. Interestingly,…”
Get full text

Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene by Hamasaki, A, Sendo, F, Nakayama, K, Ishida, N, Negishi, I, Hatakeyama, S

“…To elucidate the role of A1, a new member of the Bcl-2 family of apoptosis regulators active in hematopoietic cell apoptosis, we established mice lacking A1-a,…”
Get full text

Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation by Xiang, Z, Ahmed, A A, Möller, C, Nakayama, K, Hatakeyama, S, Nilsson, G

“…Mast cells reside in tissues, where upon activation through the high-affinity-IgE-receptor (FcepsilonRI) they degranulate and orchestrate the allergic…”
Get full text

Ubiquitin-Dependent Degradation of Iκ Bα is Mediated by a Ubiquitin Ligase Skp1/Cul 1/F-Box Protein FWD1 by Hatakeyama, Shigetsugu, Kitagawa, Masatoshi, Nakayama, Keiko, Shirane, Michiko, Matsumoto, Masaki, Hattori, Kimihiko, Higashi, Hideaki, Nakano, Hiroyasu, Okumura, Ko, Onoé, Kazunori, Good, Robert A., Nakayama, Kei-ichi

“…Activation of the transcription factor nuclear factor kappa B (NF-κ B) is controlled by proteolysis of its inhibitory subunit (Iκ B) via the…”
Get full text

Cell Cycle Regulation and Differentiation in the Human Podocyte Lineage by Nagata, Michio, Nakayama, Kei-ichi, Terada, Yoshio, Hoshi, Sachi, Watanabe, Teruo

“…Mature podocytes are regarded as growth-arrested cells with characteristic phenotypic features that underlie their function. To determine the relationship…”
Get full text

Essential role for ZAP-70 in both positive and negative selection of thymocytes by Negishi, Izumi, Motoyama, Noboru, Nakayama, Kei-ichi, Nakayama, Keiko, Senju, Satoru, Hatakeyama, Shigetsugu, Zhang, Qing, Chan, Andrew C, Loh, Dennis Y

“…During thymic development, T cells that can recognize foreign antigen in association with self major histocompatibility complex (MHC) are selected for survival…”
Get full text

U-box proteins as a new family of ubiquitin ligases by Hatakeyama, Shigetsugu, Nakayama, Kei-ichi I

“…Ubiquitin-protein ligases (E3s) determine the substrate specificity of ubiquitylation and, until recently, had been classified into two families, the HECT and…”
Get full text

Disappearance of the Lymphoid System in Bcl-2 Homozygous Mutant Chimeric Mice by Nakayama, Kei-ichi, Nakayama, Keiko, Negishi, Izumi, Kuida, Keisuke, Shinkai, Yoichi, Louie, Marjorie C., Fields, Larry E., Lucas, Phillip J., Stewart, Valerie, Alt, Frederick W., Loh, Dennis Y.

“…The bcl-2 proto-oncogene can prevent the death of many cell types. Mice were generated that were chimeric for the homozygous inactivation of bcl-2. Lymphocytes…”
Get full text