Search Results - "Nakayama, K I"

Role of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells by Takeishi, S, Nakayama, K I

“…In addition to the properties of self-renewal and multipotency, stem cells are characterised by their distinct cell cycle status. Somatic stem cells are…”
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Notch-dependent cell cycle arrest and apoptosis in mouse embryonic fibroblasts lacking Fbxw7 by Ishikawa, Y, Onoyama, I, Nakayama, K I, Nakayama, K

“…The F-box protein Fbxw7 mediates the ubiquitylation and consequent degradation of proteins that regulate cell cycle progression, including cyclin E, c-Myc,…”
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Opposing functions of Fbxw7 in keratinocyte growth, differentiation and skin tumorigenesis mediated through negative regulation of c-Myc and Notch by Ishikawa, Y, Hosogane, M, Okuyama, R, Aoyama, S, Onoyama, I, Nakayama, K I, Nakayama, K

“…The tumor suppressor Fbxw7 (also known as Sel-10, hCdc4, hAgo, or Fbw7) is an F-box protein that functions as the substrate-recognition subunit of an SCF…”
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Role of apolipoprotein B100 and oxidized low-density lipoprotein in the monocyte tissue factor induction mediated by anti-β2 glycoprotein I antibodies by Otomo, K, Amengual, O, Fujieda, Y, Nakagawa, H, Kato, M, Oku, K, Horita, T, Yasuda, S, Matsumoto, M, Nakayama, K I, Hatakeyama, S, Koike, T, Atsumi, T

“…Objective The objective of this paper is to elucidate the not yet known plasma molecule candidates involved in the induction of tissue factor (TF) expression…”
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Identification of novel E2F1 target genes regulated in cell cycle-dependent and independent manners by IWANAGA, R, KOMORI, H, ISHIDA, S, OKAMURA, N, NAKAYAMA, K, NAKAYAMA, K. I, OHTANI, K

“…The transcription factor E2F mediates cell cycle-dependent expression of genes important for cell proliferation in response to growth stimulation. To further…”
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Skp2 regulates the antiproliferative function of the tumor suppressor RASSF1A via ubiquitin-mediated degradation at the G1–S transition by Song, M S, Song, S J, Kim, S J, Nakayama, K, Nakayama, K I, Lim, D-S

“…The tumor suppressor RASSF1A is inactivated in many human cancers and is implicated in regulation of microtubule stability, cell cycle progression and…”
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Complex regulation of cell-cycle inhibitors by Fbxw7 in mouse embryonic fibroblasts by Masuda, K, Ishikawa, Y, Onoyama, I, Unno, M, de Alborán, I M, Nakayama, K I, Nakayama, K

“…The F-box protein Fbxw7 (also known as Fbw7, SEL-10, hCdc4 or hAgo) mediates the ubiquitylation and thereby contributes to the degradation of proteins that…”
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Regulation of SV40 large T-antigen stability by reversible acetylation by SHIMAZU, T, KOMATSU, Y, NAKAYAMA, K. I, FUKAZAWA, H, HORINOUCHI, S, YOSHIDA, M

“…Reversible acetylation on protein lysine residues has been shown to regulate the function of both nuclear proteins such as histones and p53 and cytoplasmic…”
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Impaired chemotaxis and cell adhesion due to decrease in several cell-surface receptors in cathepsin E-deficient macrophages by Tsukuba, Takayuki, Yanagawa, Michiyo, Okamoto, Kuniaki, Okamoto, Yoshiko, Yasuda, Yoshiyuki, Nakayama, Keiichi I, Kadowaki, Tomoko, Yamamoto, Kenji

“…Cathepsin E is an endo-lysosomal aspartic proteinase exclusively present in immune system cells. Previous studies have shown that cathepsin E-deficient…”
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Regulation of SV40 large T-antigen stability by reversible acetylation by Shimazu, T, Komatsu, Y, Nakayama, K.I, Fukazawa, H, Horinouchi, S, Yoshida, M

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U Box Proteins as a New Family of Ubiquitin-Protein Ligases by Hatakeyama, Shigetsugu, Yada, Masayoshi, Matsumoto, Masaki, Ishida, Noriko, Nakayama, Kei-Ichi

“…The U box is a domain of ∼70 amino acids that is present in proteins from yeast to humans. The prototype U box protein, yeast Ufd2, was identified as a…”
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Identification and characterization of the human Gb3/CD77 synthase gene promoter by Okuda, Tetsuya, Nakayama, Ken-ichi

“…Hemolytic uremic syndrome (HUS) is triggered by verotoxin (VT) produced by the Escherichia coli O157 strain. Several studies have demonstrated that VT induces…”
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Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: Modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis by MASUDA, Taka-Aki, INOUE, Hiroshi, SONODA, Hideto, MINE, Shinji, YOSHIKAWA, Yasuji, NAKAYAMA, Keiko, NAKAYAMA, Kei-Ichi, MORI, Masaki

“…Reduced expression level of p27, a cyclin-dependent kinase inhibitor, is associated with high aggressiveness and poor prognosis of various malignant tumors,…”
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Loss of protein kinase C delta alters mammary gland development and apoptosis by Allen-Petersen, B L, Miller, M R, Neville, M C, Anderson, S M, Nakayama, K I, Reyland, M E

“…As apoptotic pathways are commonly deregulated in breast cancer, exploring how mammary gland cell death is regulated is critical for understanding human…”
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Essential role for ZAP-70 in both positive and negative selection of thymocytes by Negishi, Izumi, Motoyama, Noboru, Nakayama, Kei-ichi, Nakayama, Keiko, Senju, Satoru, Hatakeyama, Shigetsugu, Zhang, Qing, Chan, Andrew C, Loh, Dennis Y

“…During thymic development, T cells that can recognize foreign antigen in association with self major histocompatibility complex (MHC) are selected for survival…”
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Disappearance of the Lymphoid System in Bcl-2 Homozygous Mutant Chimeric Mice by Nakayama, Kei-ichi, Nakayama, Keiko, Negishi, Izumi, Kuida, Keisuke, Shinkai, Yoichi, Louie, Marjorie C., Fields, Larry E., Lucas, Phillip J., Stewart, Valerie, Alt, Frederick W., Loh, Dennis Y.

“…The bcl-2 proto-oncogene can prevent the death of many cell types. Mice were generated that were chimeric for the homozygous inactivation of bcl-2. Lymphocytes…”
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Radiation kills human peripheral T cells by a Fas-independent mechanism by Ogawa, Y, Nishioka, A, Inomata, T, Yoshida, S, Nakayama, K I, Kataoka, S

“…The mechanism by which radiation induces human peripheral T cell apoptosis is not known. We examined sequential changes in post-irradiated peripheral blood…”
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Isolation of new temperature-sensitive mutants of Saccharomyces cerevisiae deficient in mannose outer chain elongation by Nagasu, T, Shimma, Y, Nakanishi, Y, Kuromitsu, J, Iwama, K, Nakayama, K, Suzuki, K, Jigami, Y

“…We have isolated two temperature-sensitive Saccharomyces cerevisiae mutants which exhibit a deficiency in mannose outer chain elongation of asparagine-linked…”
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Ubiquitin-dependent proteolysis by SCF complex by Nakayama, K, Nakayama, K

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OCH1 encodes a novel membrane bound mannosyltransferase: outer chain elongation of asparagine-linked oligosaccharides by Nakayama, K, Nagasu, T, Shimma, Y, Kuromitsu, J, Jigami, Y

“…The Saccharomyces cerevisiae och1 mutant shows a deficiency in the mannose outer chain elongation at the non-permissive temperature. We have cloned the OCH1…”
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