Search Results - "Nakayama, Jun‐ichi"

Structural Basis of Heterochromatin Formation by Human HP1 by Machida, Shinichi, Takizawa, Yoshimasa, Ishimaru, Masakazu, Sugita, Yukihiko, Sekine, Satoshi, Nakayama, Jun-ichi, Wolf, Matthias, Kurumizaka, Hitoshi

“…Heterochromatin plays important roles in transcriptional silencing and genome maintenance by the formation of condensed chromatin structures, which determine…”
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Researchers support preprints and open access publishing, but with reservations: A questionnaire survey of MBSJ members by Ide, Kazuki, Nakayama, Jun‐ichi

“…Since the 1990s, journals have become increasingly online and open access. In fact, about 50% of articles published in 2021 were open access. The use of…”
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H3K14 ubiquitylation promotes H3K9 methylation for heterochromatin assembly by Oya, Eriko, Nakagawa, Reiko, Yoshimura, Yuriko, Tanaka, Mayo, Nishibuchi, Gohei, Machida, Shinichi, Shirai, Atsuko, Ekwall, Karl, Kurumizaka, Hitoshi, Tagami, Hideaki, Nakayama, Jun‐ichi

“…The methylation of histone H3 at lysine 9 (H3K9me), performed by the methyltransferase Clr4/SUV39H, is a key event in heterochromatin assembly. In fission…”
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Physiological Roles of Class I HDAC Complex and Histone Demethylase by Hayakawa, Tomohiro, Nakayama, Jun-ichi

“…Epigenetic gene silencing is one of the fundamental mechanisms for ensuring proper gene expression patterns during cellular differentiation and development…”
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Biochemical and structural properties of heterochromatin protein 1: understanding its role in chromatin assembly by Nishibuchi, Gohei, Nakayama, Jun-ichi

“…Heterochromatin protein 1 (HP1) is an evolutionarily conserved chromosomal protein that binds lysine 9-methylated histone H3 (H3K9me), a hallmark of…”
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Multiple interfaces to recognize nucleosomal targets by Nakamura, Rinko, Nakayama, Jun-ichi

“…Abstract In eukaryotic cells, DNA is tightly compacted as chromatin. Chromatin states must be dynamically changed to increase the accessibility of…”
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Chromosome-associated RNA–protein complexes promote pairing of homologous chromosomes during meiosis in Schizosaccharomyces pombe by Ding, Da-Qiao, Okamasa, Kasumi, Katou, Yuki, Oya, Eriko, Nakayama, Jun-ichi, Chikashige, Yuji, Shirahige, Katsuhiko, Haraguchi, Tokuko, Hiraoka, Yasushi

“…Pairing of homologous chromosomes in meiosis is essential for sexual reproduction. We have previously demonstrated that the fission yeast sme2 RNA, a…”
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Phosphorylation of CBX2 controls its nucleosome-binding specificity by Kawaguchi, Takayuki, Machida, Shinichi, Kurumizaka, Hitoshi, Tagami, Hideaki, Nakayama, Jun-Ichi

“…Chromobox 2 (CBX2), a component of polycomb repressive complex 1 (PRC1), binds lysine 27-methylated histone H3 (H3K27me3) via its chromodomain (CD) and plays a…”
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Do the charges matter?—balancing the charges of the chromodomain proteins on the nucleosome by Hiragami-Hamada, Kyoko, Nakayama, Jun-ichi

“…Abstract The chromodomain (CD) is a member of the Royal family of conserved chromatin-binding motifs with methylated substrate binding ability, and is often…”
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Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly by Shirai, Atsuko, Kawaguchi, Takayuki, Shimojo, Hideaki, Muramatsu, Daisuke, Ishida-Yonetani, Mayumi, Nishimura, Yoshifumi, Kimura, Hiroshi, Nakayama, Jun-Ichi, Shinkai, Yoichi

“…SUV39H is the major histone H3 lysine 9 (H3K9)-specific methyltransferase that targets pericentric regions and is crucial for assembling silent…”
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Cooperative DNA-binding activities of Chp2 are critical for its function in heterochromatin assembly by Rahayu, Anisa Fitri, Hayashi, Aki, Yoshimura, Yuriko, Nakagawa, Reiko, Arita, Kyohei, Nakayama, Jun-Ichi

“…Heterochromatin protein 1 (HP1) is an evolutionarily conserved protein that plays a critical role in heterochromatin assembly. HP1 proteins share a basic…”
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Regulation of the SUV39H Family Methyltransferases: Insights from Fission Yeast by Nakamura, Rinko, Nakayama, Jun-Ichi

“…Histones, which make up nucleosomes, undergo various post-translational modifications, such as acetylation, methylation, phosphorylation, and ubiquitylation…”
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Physical and Functional Interactions between the Histone H3K4 Demethylase KDM5A and the Nucleosome Remodeling and Deacetylase (NuRD) Complex by Nishibuchi, Gohei, Shibata, Yukimasa, Hayakawa, Tomohiro, Hayakawa, Noriyo, Ohtani, Yasuko, Sinmyozu, Kaori, Tagami, Hideaki, Nakayama, Jun-ichi

“…Histone H3K4 methylation has been linked to transcriptional activation. KDM5A (also known as RBP2 or JARID1A), a member of the KDM5 protein family, is an H3K4…”
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Proteomics-Based Systematic Identification of Nuclear Proteins Anchored to Chromatin via RNA by Hiragami-Hamada, Kyoko, Tani, Naoki, Nakayama, Jun-Ichi

“…Chromatin serves as a platform for a multitude of biological processes, including transcription and co-transcriptional RNA processing. Consequently, chromatin…”
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Maintenance of self‐renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b by Tsumura, Akiko, Hayakawa, Tomohiro, Kumaki, Yuichi, Takebayashi, Shin‐ichiro, Sakaue, Morito, Matsuoka, Chisa, Shimotohno, Kunitada, Ishikawa, Fuyuki, Li, En, Ueda, Hiroki R., Nakayama, Jun‐ichi, Okano, Masaki

“…DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b cooperatively regulate cytosine methylation in CpG dinucleotides in mammalian genomes, providing an epigenetic…”
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The heterochromatin protein Swi6/HP1 activates replication origins at the pericentromeric region and silent mating-type locus by Takahashi, Tatsuro S, Nakayama, Jun-ichi, Masukata, Hisao, Hayashi, Makoto T, Nakagawa, Takuro

“…Heterochromatin is a structurally compacted region of chromosomes in which transcription and recombination are inactivated. DNA replication is temporally…”
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Meiosis‐specific cohesin component, Rec8, promotes the localization of Mps3 SUN domain protein on the nuclear envelope by Bommi, Jagadeeswara Rao, Rao, Hanumanthu Bala Durga Prasada, Challa, Kiran, Higashide, Mika, Shinmyozu, Kaori, Nakayama, Jun‐ichi, Shinohara, Miki, Shinohara, Akira

“…Proteins in the nuclear envelope (NE) play a role in the dynamics and functions of the nucleus and of chromosomes during mitosis and meiosis. Mps3, a yeast NE…”
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Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19 by Dong, Cheng, Nakagawa, Reiko, Oyama, Kyohei, Yamamoto, Yusuke, Zhang, Weilian, Dong, Aiping, Li, Yanjun, Yoshimura, Yuriko, Kamiya, Hiroyuki, Nakayama, Jun-Ichi, Ueda, Jun, Min, Jinrong

“…The Polycomb repressive complex 2 (PRC2) is a multicomponent histone H3K27 methyltransferase complex, best known for silencing the genes during embryonic…”
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Regulation of mitotic recombination between DNA repeats in centromeres by Zafar, Faria, Okita, Akiko K, Onaka, Atsushi T, Su, Jie, Katahira, Yasuhiro, Nakayama, Jun-Ichi, Takahashi, Tatsuro S, Masukata, Hisao, Nakagawa, Takuro

“…Centromeres that are essential for faithful segregation of chromosomes consist of unique DNA repeats in many eukaryotes. Although recombination is…”
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Intrinsic Nucleic Acid-Binding Activity of Chp1 Chromodomain Is Required for Heterochromatic Gene Silencing by Ishida, Mayumi, Shimojo, Hideaki, Hayashi, Aki, Kawaguchi, Rika, Ohtani, Yasuko, Uegaki, Koichi, Nishimura, Yoshifumi, Nakayama, Jun-ichi

“…Centromeric heterochromatin assembly in fission yeast requires the RNAi pathway. Chp1, a chromodomain (CD) protein, forms the Ago1-containing RNA-induced…”
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