Search Results - "Nakatsuka, Atsuko"

Mitochondrial Dynamics and Mitochondrial Dysfunction in Diabetes by Wada, Jun, Nakatsuka, Atsuko

“…The mitochondria are involved in active and dynamic processes, such as mitochondrial biogenesis, fission, fusion and mitophagy to maintain mitochondrial and…”
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Long-term treatment with the sodium glucose cotransporter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db/db mice by Terami, Naoto, Ogawa, Daisuke, Tachibana, Hiromi, Hatanaka, Takashi, Wada, Jun, Nakatsuka, Atsuko, Eguchi, Jun, Horiguchi, Chikage Sato, Nishii, Naoko, Yamada, Hiroshi, Takei, Kohji, Makino, Hirofumi

“…Inhibition of sodium glucose cotransporter 2 (SGLT2) has been reported as a new therapeutic strategy for treating diabetes. However, the effect of SGLT2…”
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Identification of Circulating miR-101, miR-375 and miR-802 as Biomarkers for Type 2 Diabetes by Higuchi, Chigusa, Nakatsuka, Atsuko, Eguchi, Jun, Teshigawara, Sanae, Kanzaki, Motoko, Katayama, Akihiro, Yamaguchi, Satoshi, Takahashi, Naoto, Murakami, Kazutoshi, Ogawa, Daisuke, Sasaki, Sakiko, Makino, Hirofumi, Wada, Jun

“…Abstract Purpose The unique circulating microRNAs (miRNAs) observed in patients with type 2 diabetes (T2D) are candidates as new biomarkers and therapeutic…”
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Current Status of Familial LCAT Deficiency in Japan by Kuroda, Masayuki, Bujo, Hideaki, Yokote, Koutaro, Murano, Takeyoshi, Yamaguchi, Takashi, Ogura, Masatsune, Ikewaki, Katsunori, Koseki, Masahiro, Takeuchi, Yasuo, Nakatsuka, Atsuko, Hori, Mika, Matsuki, Kota, Miida, Takashi, Yokoyama, Shinji, Wada, Jun, Harada-Shiba, Mariko

“…Lecithin cholesterol acyltransferase (LCAT) is a lipid-modification enzyme that catalyzes the transfer of the acyl chain from the second position of lecithin…”
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Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2 by Nunoue, Tomokazu, Yamaguchi, Satoshi, Teshigawara, Sanae, Katayama, Akihiro, Nakatsuka, Atsuko, Eguchi, Jun, Niki, Toshiro, Wada, Jun

“…The adipose tissue is regarded as an endocrine organ and secretes bioactive adipokines modulating chronic inflammation and oxidative stress in obesity. Gal-9…”
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Dysfunction of CD8 + PD-1 + T cells in type 2 diabetes caused by the impairment of metabolism-immune axis by Nojima, Ichiro, Eikawa, Shingo, Tomonobu, Nahoko, Hada, Yoshiko, Kajitani, Nobuo, Teshigawara, Sanae, Miyamoto, Satoshi, Tone, Atsuhito, Uchida, Haruhito A., Nakatsuka, Atsuko, Eguchi, Jun, Shikata, Kenichi, Udono, Heiichiro, Wada, Jun

“…The metabolic changes and dysfunction in CD8 + T cells may be involved in tumor progression and susceptibility to virus infection in type 2 diabetes (T2D). In…”
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Author Correction: Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2 by Nunoue, Tomokazu, Yamaguchi, Satoshi, Teshigawara, Sanae, Katayama, Akihiro, Nakatsuka, Atsuko, Eguchi, Jun, Niki, Toshiro, Wada, Jun

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Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice by Kawai, Daisuke, Takaki, Akinobu, Nakatsuka, Atsuko, Wada, Jun, Tamaki, Naofumi, Yasunaka, Tetsuya, Koike, Kazuko, Tsuzaki, Ryuichiro, Matsumoto, Kazuyuki, Miyake, Yasuhiro, Shiraha, Hidenori, Morita, Manabu, Makino, Hirofumi, Yamamoto, Kazuhide

“…Oxidative stress is a strong contributor to the progression from simple fatty liver to nonalcoholic steatohepatitis (NASH). Molecular hydrogen is an effective…”
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Vaspin Is an Adipokine Ameliorating ER Stress in Obesity as a Ligand for Cell-Surface GRP78/MTJ-1 Complex by NAKATSUKA, Atsuko, WADA, Jun, HIDA, Kazuyuki, EGUCHI, Jun, HORIGUCHI, Chikage Sato, OGAWA, Daisuke, MATSUKI, Yasushi, HIRAMATSU, Ryuji, YAGITA, Hideo, KAKUTA, Shigeru, IWAKURA, Yoichiro, MAKINO, Hirofumi, ISEDA, Izumi, TESHIGAWARA, Sanae, HIGASHIO, Kanji, MURAKAMI, Kazutoshi, KANZAKI, Motoko, INOUE, Kentaro, TERAMI, Takahiro, KATAYAMA, Akihiro

“…It is unknown whether adipokines derived from adipose tissues modulate endoplasmic reticulum (ER) stress induced in obesity. Here, we show that visceral…”
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Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis by Katayama, Akihiro, Nakatsuka, Atsuko, Eguchi, Jun, Murakami, Kazutoshi, Teshigawara, Sanae, Kanzaki, Motoko, Nunoue, Tomokazu, Hida, Kazuyuki, Wada, Nozomu, Yasunaka, Tetsuya, Ikeda, Fusao, Takaki, Akinobu, Yamamoto, Kazuhide, Kiyonari, Hiroshi, Makino, Hirofumi, Wada, Jun

“…Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. Gpnmb is classified as a type 1 membrane protein and its…”
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Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4 by Yamaguchi, Satoshi, Zhang, Dongxiao, Katayama, Akihiro, Kurooka, Naoko, Sugawara, Ryosuke, Albuayjan, Haya Hamed Hassan, Nakatsuka, Atsuko, Eguchi, Jun, Wada, Jun

“…MicroRNAs expressed in adipocytes are involved in transcriptional regulation of target mRNAs in obesity, but miRNAs critically involved in this process is not…”
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A Vaspin–HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease by Nakatsuka, Atsuko, Yamaguchi, Satoshi, Eguchi, Jun, Kakuta, Shigeru, Iwakura, Yoichiro, Sugiyama, Hitoshi, Wada, Jun

“…Proximal tubular cells (PTCs) are crucial for maintaining renal homeostasis, and tubular injuries contribute to progression of diabetic kidney disease (DKD)…”
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Insufficiency of phosphatidylethanolamine N-methyltransferase is risk for lean non-alcoholic steatohepatitis by Nakatsuka, Atsuko, Matsuyama, Makoto, Yamaguchi, Satoshi, Katayama, Akihiro, Eguchi, Jun, Murakami, Kazutoshi, Teshigawara, Sanae, Ogawa, Daisuke, Wada, Nozomu, Yasunaka, Tetsuya, Ikeda, Fusao, Takaki, Akinobu, Watanabe, Eijiro, Wada, Jun

“…Although obesity is undoubtedly major risk for non-alcoholic steatohepatitis (NASH), the presence of lean NASH patients with normal body mass index has been…”
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Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity by Hida, K, Wada, J, Eguchi, J, Zhang, H, Baba, M, Seida, A, Hashimoto, I, Okada, T, Yasuhara, A, Nakatsuka, A

“…There is a rapid global rise in obesity, and the link between obesity and diabetes remains somewhat obscure. We identified an adipocytokine, designated as…”
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Visceral Adipose Tissue-derived Serine Proteinase Inhibitor Inhibits Apoptosis of Endothelial Cells as a Ligand for the Cell-Surface GRP78/Voltage-dependent Anion Channel Complex by Nakatsuka, Atsuko, Wada, Jun, Iseda, Izumi, Teshigawara, Sanae, Higashio, Kanji, Murakami, Kazutoshi, Kanzaki, Motoko, Inoue, Kentaro, Terami, Takahiro, Katayama, Akihiro, Hida, Kazuyuki, Eguchi, Jun, Ogawa, Daisuke, Matsuki, Yasushi, Hiramatsu, Ryuji, Yagita, Hideo, Kakuta, Shigeru, Iwakura, Yoichiro, Makino, Hirofumi

“…RATIONALE:Visceral adipose tissue-derived serine proteinase inhibitor (vaspin) is an adipokine identified from visceral adipose tissues of genetically obese…”
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Urinary fetuin-A is a novel marker for diabetic nephropathy in type 2 diabetes identified by lectin microarray by Inoue, Kentaro, Wada, Jun, Eguchi, Jun, Nakatsuka, Atsuko, Teshigawara, Sanae, Murakami, Kazutoshi, Ogawa, Daisuke, Terami, Takahiro, Katayama, Akihiro, Tone, Atsuhito, Iseda, Izumi, Hida, Kazuyuki, Yamada, Masao, Ogawa, Tomohisa, Makino, Hirofumi

“…We analyzed the urine samples of patients with type 2 diabetes at various stages of diabetic nephropathy by lectin microarray to identify a biomarker to…”
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High expression of a vascular stricture‐related marker is predictive of an early response to tolvaptan, and a low fractional excretion of sodium is predictive of a poor long‐term survival after tolvaptan administration for liver cirrhosis by Adachi, Takuya, Takaki, Akinobu, Sato, Shuichi, Tobita, Hiroshi, Kobashi, Haruhiko, Kinomura, Masaru, Nakatsuka, Atsuko, Oyama, Atsushi, Wada, Nozomu, Sakata, Masahiro, Takeuchi, Yasuto, Yasunaka, Tetsuya, Onishi, Hideki, Shiraha, Hidenori, Okada, Hiroyuki

“…Aim Tolvaptan is a newly available diuretic that has a specific function in water reabsorption inhibition. Given that spironolactone or furosemide induces the…”
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The hypoglycemia-prevention effect of sensor-augmented pump therapy with predictive low glucose management in Japanese patients with type 1 diabetes mellitus: a short-term study by Katayama, Akihiro, Tone, Atsuhito, Watanabe, Mayu, Teshigawara, Sanae, Miyamoto, Satoshi, Eguchi, Jun, Nakatsuka, Atsuko, Shikata, Kenichi, Wada, Jun

“…Aims/introduction The predictive low glucose management (PLGM) system was introduced in March 2018 in Japan. Although there are some reports demonstrating the…”
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Upregulation of Mir342 in Diet-Induced Obesity Mouse and the Hypothalamic Appetite Control by Zhang, Dongxiao, Yamaguchi, Satoshi, Zhang, Xinhao, Yang, Boxuan, Kurooka, Naoko, Sugawara, Ryosuke, Albuayjan, Haya Hamed H, Nakatsuka, Atsuko, Eguchi, Jun, Hiyama, Takeshi Y, Kamiya, Atsunori, Wada, Jun

“…In obesity and type 2 diabetes, numerous genes are differentially expressed, and microRNAs are involved in transcriptional regulation of target mRNAs, but…”
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Antiobesity Action of ACAM by Modulating the Dynamics of Cell Adhesion and Actin Polymerization in Adipocytes by Murakami, Kazutoshi, Eguchi, Jun, Hida, Kazuyuki, Nakatsuka, Atsuko, Katayama, Akihiro, Sakurai, Miwa, Choshi, Haruki, Furutani, Masumi, Ogawa, Daisuke, Takei, Kohji, Otsuka, Fumio, Wada, Jun

“…Coxsackie virus and adenovirus receptor-like membrane protein (CLMP) was identified as the tight junction-associated transmembrane protein of epithelial cells…”
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