Search Results - "Nakata, Masanori"

Ghrelin signaling in the cerebellar cortex enhances GABAergic transmission onto Purkinje cells by Hirono, Moritoshi, Nakata, Masanori

“…Ghrelin, an orexigenic peptide ligand for growth hormone secretagogue receptor 1a (GHS-R1a), occurs not only in the stomach but also in the brain, and…”
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GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose by Iwasaki, Yusaku, Sendo, Mio, Dezaki, Katsuya, Hira, Tohru, Sato, Takehiro, Nakata, Masanori, Goswami, Chayon, Aoki, Ryohei, Arai, Takeshi, Kumari, Parmila, Hayakawa, Masaki, Masuda, Chiaki, Okada, Takashi, Hara, Hiroshi, Drucker, Daniel J., Yamada, Yuichiro, Tokuda, Masaaki, Yada, Toshihiko

“…Overeating and arrhythmic feeding promote obesity and diabetes. Glucagon-like peptide-1 receptor (GLP-1R) agonists are effective anti-obesity drugs but their…”
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TRPV1-Mediated Sensing of Sodium and Osmotic Pressure in POMC Neurons in the Arcuate Nucleus of the Hypothalamus by Zhang, Boyang, Kario, Kazuomi, Yada, Toshihiko, Nakata, Masanori

“…The central melanocortin system conducted by anorexigenic pro-opiomelanocortin (POMC) neurons and orexigenic agouti-related peptide (AgRP) neurons in the…”
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Nesfatin-1 enhances glucose-induced insulin secretion by promoting Ca2+ influx through L-type channels in mouse islet β-cells by Nakata, Masanori, Manaka, Kazunori, Yamamoto, Sawako, Mori, Masatomo, Yada, Toshihiko

“…Nucleobindin-2 (NUCB2)-derived nesfatin-1 located in the brain has been implicated in the satiety and control of energy metabolism. Nesfatin-1 is also produced…”
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Nesfatin-1 Neurons in Paraventricular and Supraoptic Nuclei of the Rat Hypothalamus Coexpress Oxytocin and Vasopressin and Are Activated by Refeeding by Kohno, Daisuke, Nakata, Masanori, Maejima, Yuko, Shimizu, Hiroyuki, Sedbazar, Udval, Yoshida, Natsu, Dezaki, Katsuya, Onaka, Tatsushi, Mori, Masatomo, Yada, Toshihiko

“…Nesfatin-1, a newly discovered satiety molecule, is located in the hypothalamic nuclei, including the paraventricular nucleus (PVN) and supraoptic nucleus…”
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Role of NUCB2/nesfatin-1 in glucose control: diverse functions in islets, adipocytes and brain by Nakata, Masanori, Yada, Toshihiko

“…The novel satiety factor nesfatin-1 and its precursor NUCB2 are the neuropeptides widely expressed in the central nervous system. Nesfatin-1/NUCB2 is also…”
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1,5-Anhydro-D-Fructose Exhibits Satiety Effects via the Activation of Oxytocin Neurons in the Paraventricular Nucleus by Nakata, Masanori, Yamaguchi, Yuto, Monnkawa, Hikaru, Takahashi, Midori, Zhang, Boyang, Santoso, Putra, Yada, Toshihiko, Maruyama, Ikuro

“…1,5-Anhydro-D-fructose (1,5-AF) is a bioactive monosaccharide that is produced by the glycogenolysis in mammalians and is metabolized to 1,5-anhydro-D-glucitol…”
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Paraventricular NUCB2/Nesfatin-1 Supports Oxytocin and Vasopressin Neurons to Control Feeding Behavior and Fluid Balance in Male Mice by Nakata, Masanori, Gantulga, Darambazar, Santoso, Putra, Zhang, Boyang, Masuda, Chiaki, Mori, Masatomo, Okada, Takashi, Yada, Toshihiko

“…Nesfatin-1, derived from nucleobindin-2 (NUCB2), is expressed in the hypothalamus, including the paraventricular nucleus (PVN), an integrative center for…”
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Circadian Clock Component BMAL1 in the Paraventricular Nucleus Regulates Glucose Metabolism by Nakata, Masanori, Kumari, Parmila, Kita, Rika, Katsui, Nanako, Takeuchi, Yuriko, Kawaguchi, Tomoki, Yamazaki, Toshiya, Zhang, Boyang, Shimba, Shigeki, Yada, Toshihiko

“…It is suggested that clock genes link the circadian rhythm to glucose and lipid metabolism. In this study, we explored the role of the clock gene in the…”
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Nesfatin-1-Regulated Oxytocinergic Signaling in the Paraventricular Nucleus Causes Anorexia through a Leptin-Independent Melanocortin Pathway by Maejima, Yuko, Sedbazar, Udval, Suyama, Shigetomo, Kohno, Daisuke, Onaka, Tatsushi, Takano, Eisuke, Yoshida, Natsu, Koike, Masato, Uchiyama, Yasuo, Fujiwara, Ken, Yashiro, Takashi, Horvath, Tamas L., Dietrich, Marcelo O., Tanaka, Shigeyasu, Dezaki, Katsuya, Hashimoto, Koushi, Shimizu, Hiroyuki, Nakata, Masanori, Mori, Masatomo, Yada, Toshihiko

“…The hypothalamic paraventricular nucleus (PVN) functions as a center to integrate various neuronal activities for regulating feeding behavior. Nesfatin-1, a…”
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AAV-mediated IL-10 gene transfer counteracts inflammation in the hypothalamic arcuate nucleus and obesity induced by high-fat diet by Nakata, Masanori, Yamamoto, Sawako, Okada, Takashi, Yada, Toshihiko

“…Abstract Consumption of high-fat diet (HFD) induces energy imbalance and consequently obesity. In the pathogenesis of obesity, HFD triggers inflammation in the…”
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Coexistence of sensory qualities and value representations in human orbitofrontal cortex by Yoshimoto, Takaaki, Okazaki, Shuntaro, Sumiya, Motofumi, Takahashi, Haruka K., Nakagawa, Eri, Koike, Takahiko, Kitada, Ryo, Okamoto, Shiki, Nakata, Masanori, Yada, Toshihiko, Kosaka, Hirotaka, Sadato, Norihiro, Chikazoe, Junichi

“…Despite the multiple regions and neural networks associated with value-based decision-making, the orbitofrontal cortex (OFC) is possible a particularly…”
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Central Glucagon-like Peptide-1 Receptor Signaling via Brainstem Catecholamine Neurons Counteracts Hypertension in Spontaneously Hypertensive Rats by Katsurada, Kenichi, Nakata, Masanori, Saito, Toshinobu, Zhang, Boyang, Maejima, Yuko, Nandi, Shyam S., Sharma, Neeru M., Patel, Kaushik P., Kario, Kazuomi, Yada, Toshihiko

“…Glucagon-like peptide-1 receptor (GLP-1R) agonists, widely used to treat type 2 diabetes, reduce blood pressure (BP) in hypertensive patients. Whether this…”
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Glucose and insulin induce Ca2+ signaling in nesfatin-1 neurons in the hypothalamic paraventricular nucleus by Gantulga, Darambazar, Maejima, Yuko, Nakata, Masanori, Yada, Toshihiko

“…► Meal-evoked high glucose and insulin increase [Ca2+]i in PVN nesfatin-1 neurons. ► Glucose and insulin target a common subpopulation of PVN nesfatin-1…”
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Dec1 Deficiency Suppresses Cardiac Perivascular Fibrosis Induced by Transverse Aortic Constriction by Le, Hue Thi, Sato, Fuyuki, Kohsaka, Akira, Bhawal, Ujjal K, Nakao, Tomomi, Muragaki, Yasuteru, Nakata, Masanori

“…Cardiac fibrosis is a major cause of cardiac dysfunction in hypertrophic hearts. Differentiated embryonic chondrocyte gene 1 (Dec1), a basic helix-loop-helix…”
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Islet β-cell-produced NUCB2/nesfatin-1 maintains insulin secretion and glycemia along with suppressing UCP-2 in β-cells by Yang, Yifei, Zhang, Boyang, Nakata, Masanori, Nakae, Jun, Mori, Masatomo, Yada, Toshihiko

“…Nesfatin-1 is a hypothalamic anorexigenic peptide processed from nucleobindin 2 (NUCB2). Central and peripheral administration of NUCB2/nesfatin-1 enhances…”
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Blockade of Pancreatic Islet–Derived Ghrelin Enhances Insulin Secretion to Prevent High-Fat Diet–Induced Glucose Intolerance by DEZAKI, Katsuya, SONE, Hideyuki, KOIZUMI, Masaru, NAKATA, Masanori, KAKEI, Masafumi, NAGAI, Hideo, HOSODA, Hiroshi, KANGAWA, Kenji, YADA, Toshihiko

“…Blockade of Pancreatic Islet–Derived Ghrelin Enhances Insulin Secretion to Prevent High-Fat Diet–Induced Glucose Intolerance Katsuya Dezaki 1 , Hideyuki Sone 1…”
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Lavender Oil Reduces Depressive Mood in Healthy Individuals and Enhances the Activity of Single Oxytocin Neurons of the Hypothalamus Isolated from Mice: A Preliminary Study by Asakawa, Akihiro, Yada, Toshihiko, Zhang, Boyang, Fukumoto, Takamasa, Okawa, Ayumi, Yagi, Takakazu, Suzuki, Hajime, Ataka, Koji, Ogata, Keizaburo, Nakata, Masanori

“…Background. The aim of the present study was to assess the effects of lavender oil inhalation on blood pressure, pulse measurements, cortisol levels,…”
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Fibroblast growth factor 21, assisted by elevated glucose, activates paraventricular nucleus NUCB2/Nesfatin-1 neurons to produce satiety under fed states by Santoso, Putra, Nakata, Masanori, Shiizaki, Kazuhiro, Boyang, Zhang, Parmila, Kumari, Otgon-Uul, Zesemdorj, Hashimoto, Koshi, Satoh, Tetsurou, Mori, Masatomo, Kuro-o, Makoto, Yada, Toshihiko

“…Fibroblast growth factor 21 (FGF21), liver-derived hormone, exerts diverse metabolic effects, being considered for clinical application to treat obesity and…”
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Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat by Okamoto, Shiki, Sato, Tatsuya, Tateyama, Michihiro, Kageyama, Haruaki, Maejima, Yuko, Nakata, Masanori, Hirako, Satoshi, Matsuo, Takashi, Kyaw, Sanda, Shiuchi, Tetsuya, Toda, Chitoku, Sedbazar, Udval, Saito, Kumiko, Asgar, Nur Farehan, Zhang, Boyang, Yokota, Shigefumi, Kobayashi, Kenta, Foufelle, Fabienne, Ferré, Pascal, Nakazato, Masamitsu, Masuzaki, Hiroaki, Shioda, Seiji, Yada, Toshihiko, Kahn, Barbara B., Minokoshi, Yasuhiko

“…Food selection is essential for metabolic homeostasis and is influenced by nutritional state, food palatability, and social factors such as stress. However,…”
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