Search Results - "Nakashima, Shigeru"

Protein Kinase Cα (PKCα): Regulation and Biological Function by Nakashima, Shigeru

“…Protein kinase Cα (PKCα) is a serine/threonine kinase and a member of the conventional (classical) PKCs (cPKCs), which have four conserved (C1 to C4) regions…”
Get full text

Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy by Ikegame, Yuka, Yamashita, Kentaro, Hayashi, Shin-Ichiro, Mizuno, Hiroshi, Tawada, Masahiro, You, Fukka, Yamada, Kiyofumi, Tanaka, Yoshitaka, Egashira, Yusuke, Nakashima, Shigeru, Yoshimura, Shin-Ichi, Iwama, Toru

“…Abstract Background aims Transplantation of mesenchymal stromal cells (MSC) derived from bone marrow (BM) or adipose tissue is expected to become a cell…”
Get full text

Epidermal Growth Factor Plays a Crucial Role in Mitogenic Regulation of Human Brain Tumor Stem Cells by Soeda, Akio, Inagaki, Akihito, Oka, Naoki, Ikegame, Yuka, Aoki, Hitomi, Yoshimura, Shin-ichi, Nakashima, Shigeru, Kunisada, Takahiro, Iwama, Toru

“…A cancer stem cell population in malignant brain tumors takes an essential part in brain tumor initiation, growth, and recurrence. Growth factors, such as…”
Get full text

Human gastric cancer organizes neighboring lymphatic vessels via recruitment of bone marrow-derived lymphatic endothelial progenitor cells by Tawada, Masahiro, Hayashi, Shin-ichiro, Osada, Shinji, Nakashima, Shigeru, Yoshida, Kazuhiro

“…Background Lymphatic metastasis is a critical determinant of prognosis in human gastrointestinal cancers. Studies suggest that lymphatic metastasis has been…”
Get full text

Possible involvement of tumor-producing VEGF-A in the recruitment of lymphatic endothelial progenitor cells from bone marrow by TAWADA, MASAHIRO, HAYASHI, SHIN-ICHIRO, IKEGAME, YUKA, NAKASHIMA, SHIGERU, YOSHIDA, KAZUHIRO

“…Lymphatic metastasis of human malignant adenocarcinomas is a critical determinant of prognosis. Lymphangiogenesis, the growth of lymphatic vessels, is closely…”
Get full text

Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons by Yamashita, Kentaro, Kotani, Yoshinori, Nakajima, Yoshimi, Shimazawa, Masamitsu, Yoshimura, Shin-ichi, Nakashima, Shigeru, Iwama, Toru, Hara, Hideaki

“…Abstract Background and purpose Recently, fasudil, a Rho kinase (ROCK) inhibitor, was reported to prevent cerebral ischemia in vivo by increasing cerebral…”
Get full text

Cell permeable ROS scavengers, Tiron and Tempol, rescue PC12 cell death caused by pyrogallol or hypoxia/reoxygenation by Yamada, Jun, Yoshimura, Shinichi, Yamakawa, Haruki, Sawada, Motoshi, Nakagawa, Masanori, Hara, Shigeru, Kaku, Yasuhiko, Iwama, Toru, Naganawa, Takashi, Banno, Yoshiko, Nakashima, Shigeru, Sakai, Noboru

“…The role of superoxide anion (O 2 −) in neuronal cell injury induced by reactive oxygen species (ROS) was examined in PC12 cells using pyrogallol…”
Get full text

Neutrophil elastase inhibitor prevents ischemic brain damage via reduction of vasogenic edema by Ikegame, Yuka, Yamashita, Kentaro, Hayashi, Shin-ichiro, Yoshimura, Shin-ichi, Nakashima, Shigeru, Iwama, Toru

Get full text

p53 regulates ceramide formation by neutral sphingomyelinase through reactive oxygen species in human glioma cells by SAWADA, Motoshi, NAKASHIMA, Shigeru, SAKAI, Noboru, KIYONO, Tohru, NAKAGAWA, Masanori, YAMADA, Jun, YAMAKAWA, Haruki, BANNO, Yoshiko, SHINODA, Jun, NISHIMURA, Yasuaki, NOZAWA, Yoshinori

“…The present study was designed to elucidate the relationship between p53 and ceramide, both of which are involved in apoptotic signaling. Treatment of human…”
Get full text

Tumor Necrosis Factor Alpha-Induced Interleukin-8 Production via NF-κB and Phosphatidylinositol 3-Kinase/Akt Pathways Inhibits Cell Apoptosis in Human Hepatocytes by OSAWA, Yosuke, NAGAKI, Masahito, BANNO, Yoshiko, BRENNER, David A, ASANO, Takahiko, NOZAWA, Yoshinori, MORIWAKI, Hisataka, NAKASHIMA, Shigeru

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells by SAWADA, M, NAKASHIMA, S, BANNO, Y, YAMAKAWA, H, TAKENAKA, K, SHINODA, J, NISHIMURA, Y, SAKAI, N, NOZAWA, Y

“…Ceramide has recently been regarded as a potential mediator of apoptosis. In the present study, the effects of Bcl-2 and Bax on the ceramide-mediated apoptotic…”
Get full text

Cloning and Disruption of caPLB1, a Phospholipase B Gene Involved in the Pathogenicity of Candida albicans by Leidich, Steven D., Ibrahim, Ashraf S., Fu, Yue, Koul, Anjni, Jessup, Chad, Vitullo, John, Fonzi, William, Mirbod, Fariba, Nakashima, Shigeru, Nozawa, Yoshinori, Ghannoum, Mahmoud A.

“…The Candida albicans PLB1gene was cloned using a polymerase chain reaction-based approach relying on degenerate oligonucleotide primers designed according to…”
Get full text

Overexpression of immediate early gene X-1 (IEX-1) enhances γ-radiation-induced apoptosis of human glioma cell line, U87-MG by Yamashita, Kentaro, Nakashima, Shigeru, You, Fukka, Hayashi, Shin-ichiro, Iwama, Toru

“…Malignant gliomas are usually incurable even if adjuvant therapy is delivered after neurosurgical treatment. Therefore, to enhance their radiation‐induced…”
Get full text

Involvement of Phospholipase D in Sphingosine 1-Phosphate-induced Activation of Phosphatidylinositol 3-Kinase and Akt in Chinese Hamster Ovary Cells Overexpressing EDG3 by Banno, Yoshiko, Takuwa, Yoh, Akao, Yukihiro, Okamoto, Hiroyuki, Osawa, Yosuke, Naganawa, Takashi, Nakashima, Shigeru, Suh, Pann-Ghill, Nozawa, Yoshinori

“…Phospholipase D (PLD), phosphatidylinositol 3-kinase (PI3K), and Akt are known to be involved in cellular signaling related to proliferation and cell survival…”
Get full text

Inhibition of Neutral Sphingomyelinase Activation and Ceramide Formation by Glutathione in Hypoxic PC12 Cell Death by Yoshimura, Shin‐ichi, Banno, Yoshiko, Nakashima, Shigeru, Hayashi, Katsuhiko, Yamakawa, Haruki, Sawada, Motoshi, Sakai, Noboru, Nozawa, Yoshinori

“…: Reduced glutathione (GSH) and N‐acetylcysteine (NAC), but not other antioxidative or reducing agents, were found to inhibit cell death, both apoptosis and…”
Get full text

Possible role of phospholipase D in cellular differentiation and apoptosis by Nakashima, Shigeru, Nozawa, Yoshinori

“…Phospholipase D (PLD) is widely distributed in mammalian cells and is implicated in a variety of physiological processes that reveal it to be a member of the…”
Get full text

Estradiol Stabilizes p53 Protein in Breast Cancer Cell Line, MCF–7 by Okumura, Naoki, Saji, Shigehira, Eguchi, Hidetaka, Hayashi, Shin‐ichi, Saji, Shigetoyo, Nakashima, Shigeru

“…Overexpression of the oncoprotein MDM2, an important regulator of the p53 tumor suppressor protein, is often observed in breast cancer tissues and cell lines,…”
Get full text

Inositol by Nakashima, Shigeru

Get more information

Differential Phospholipase D Activation by Bradykinin and Sphingosine 1-Phosphate in NIH 3T3 Fibroblasts Overexpressing Gelsolin by Banno, Yoshiko, Fujita, Hisakazu, Ono, Yoshitaka, Nakashima, Shigeru, Ito, Yuzuru, Kuzumaki, Noboru, Nozawa, Yoshinori

“…Gelsolin, an actin-binding protein, shows a strong ability to bind to phosphatidylinositol 4,5-bisphosphate (PIP2). Here we showed in in vitroexperiments that…”
Get full text

Effect of high-NaCl or high-KCl diet on hepatic Na+- and K+-receptor sensitivity and NKCC1 expression in rats by Tsuchiya, You, Nakashima, Shigeru, Banno, Yoshiko, Suzuki, Yuichi, Morita, Hironobu

“…We previously reported that the bumetanide-sensitive Na(+)-K(+)-2Cl- cotransporter (NKCC1) is involved in the hepatic Na+ and K+ sensor mechanism. In the…”
Get more information