Search Results - "Nakashima, Masato"

TAK-071, a muscarinic M1 receptor positive allosteric modulator, attenuates scopolamine-induced quantitative electroencephalogram power spectral changes in cynomolgus monkeys by Kurimoto, Emi, Nakashima, Masato, Kimura, Haruhide, Suzuki, Motohisa

“…Activation of the muscarinic M1 receptor is a promising approach to improve cognitive deficits associated with cholinergic dysfunction in Alzheimer's disease,…”
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Selective regulation of the chitin‐induced defense response by the Arabidopsis receptor‐like cytoplasmic kinase PBL27 by Shinya, Tomonori, Yamaguchi, Koji, Desaki, Yoshitake, Yamada, Kenta, Narisawa, Tomoko, Kobayashi, Yoshihiro, Maeda, Kanako, Suzuki, Maruya, Tanimoto, Takumi, Takeda, Jun, Nakashima, Masato, Funama, Ryota, Narusaka, Mari, Narusaka, Yoshihiro, Kaku, Hanae, Kawasaki, Tsutomu, Shibuya, Naoto

“…Recognition of microbe‐associated molecular patterns (MAMPs) initiates pattern‐triggered immunity in host plants. Pattern recognition receptors (PRRs) and…”
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Practicality of multilayer round window reinforcement in the surgical management of superior semicircular canal dehiscence syndrome: a case report of long-term follow-up by Sawada, Masafumi, Matsuda, Han, Tanzawa, Yasuhiko, Sakamoto, Kei, Kudo, Hiroe, Nakashima, Masato, Ikezono, Tetsuo

“…Several surgical techniques have been documented for approaching and repairing superior semicircular canal dehiscence syndrome (SCDS). These techniques…”
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Autophosphorylation of Specific Threonine and Tyrosine Residues in Arabidopsis CERK1 is Essential for the Activation of Chitin-Induced Immune Signaling by Suzuki, Maruya, Shibuya, Masatoshi, Shimada, Hikaru, Motoyama, Noriko, Nakashima, Masato, Takahashi, Shohei, Suto, Kenkichi, Yoshida, Issei, Matsui, Saki, Tsujimoto, Natsumi, Ohnishi, Mihoko, Ishibashi, Yuko, Fujimoto, Zui, Desaki, Yoshitake, Kaku, Hanae, Kito, Keiji, Shibuya, Naoto

“…Pattern recognition receptors on the plant cell surface mediate the recognition of microbe/damage-associated molecular patterns (MAMPs/DAMPs) and activate…”
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Electrical impedance myography detects dystrophin-related muscle changes in mdx mice by Hiyoshi, Tetsuaki, Zhao, Fuqiang, Baba, Rina, Hirakawa, Takeshi, Kuboki, Ryosuke, Suzuki, Kazunori, Tomimatsu, Yoshiro, O'Donnell, Patricio, Han, Steve, Zach, Neta, Nakashima, Masato

“…The lack of functional dystrophin protein in Duchenne muscular dystrophy (DMD) causes chronic skeletal muscle inflammation and degeneration. Therefore, the…”
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Discovery of a Novel Series of Pyrazolo[1,5-a]pyrimidine-Based Phosphodiesterase 2A Inhibitors Structurally Different from N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), for the Treatment of Cognitive Disorders by Mikami, Satoshi, Kawasaki, Masanori, Ikeda, Shuhei, Negoro, Nobuyuki, Nakamura, Shinji, Nomura, Izumi, Ashizawa, Tomoko, Kokubo, Hironori, Hoffman, Isaac Dylan, Zou, Hua, Oki, Hideyuki, Uchiyama, Noriko, Hiura, Yuuto, Miyamoto, Maki, Itou, Yuuki, Nakashima, Masato, Iwashita, Hiroki, Taniguchi, Takahiko

“…It has been hypothesized that selective inhibition of phosphodiesterase (PDE) 2A could potentially be a novel approach to treat cognitive impairment in…”
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Participation of prostaglandin E receptor EP4 subtype in duodenal bicarbonate secretion in rats by Aoi, Masako, Aihara, Eitaro, Nakashima, Masato, Takeuchi, Koji

“…We examined, by using a specific PGE receptor subtype EP4 agonist and antagonist, the involvement of EP4 receptors in duodenal HCO(3)(-) secretion induced by…”
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Facilitation by endogenous prostaglandins of capsaicin-induced gastric protection in rodents through EP2 and IP receptors by Takeuchi, Koji, Kato, Shinichi, Takeeda, Masanori, Ogawa, Yoshihiro, Nakashima, Masato, Matsumoto, Masahiro

“…We investigated the role that prostaglandins (PGs) and EP receptors play in facilitating the gastroprotective action of capsaicin against HCl/ethanol in rats…”
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Tonsillar cyst of the false vocal cord by Kimura, Miwako, Nakashima, Masato, Nito, Takaharu, Tayama, Niro

“…To report, for the first time, tonsillar cyst of the false vocal cord. Case report. Case presentation and literature review. A 74-year-old woman with a mass in…”
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TAK-915, a phosphodiesterase 2A inhibitor, ameliorates the cognitive impairment associated with aging in rodent models by Nakashima, Masato, Suzuki, Noriko, Shiraishi, Eri, Iwashita, Hiroki

“…•TAK-915 facilitated the spatial learning in aged rats in the Morris water maze task.•TAK-915 attenuated scopolamine-induced memory deficits in rats.•TAK-915…”
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A case of nasal natural killer/T lymphoma revealed by repeated deep neck abscess by Baba, Shintaro, MD, Baba, Miyuki, MD, Hagisawa, Miho, MD, Kimura, Miwako, MD, Nakashima, Masato, MD, Nakahara, Haruka, MD

“…Abstract A diagnosis of natural killer (NK)/T-cell lymphoma was clarified after repeated deep neck abscess in a 63-year-old man. The absolute number of…”
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Discovery of a Potent and Orally Bioavailable Melatonin Receptor Agonist by Hoashi, Yasutaka, Takai, Takafumi, Kosugi, Yohei, Nakashima, Masato, Nakayama, Masaharu, Hirai, Keisuke, Uchikawa, Osamu, Koike, Tatsuki

“…To develop potent and orally bioavailable melatonin receptor (MT1 and MT2) agonists, a novel series of 5–6–5 tricyclic derivatives was designed, synthesized,…”
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TAK-071, a muscarinic M.sub.1 receptor positive allosteric modulator, attenuates scopolamine-induced quantitative electroencephalogram power spectral changes in cynomolgus monkeys by Kurimoto, Emi, Nakashima, Masato, Kimura, Haruhide, Suzuki, Motohisa

“…Activation of the muscarinic M.sub.1 receptor is a promising approach to improve cognitive deficits associated with cholinergic dysfunction in Alzheimer's…”
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IgG4-related Mikulicz's disease: a report of 3 cases by Nakada, Hiroto, Shibasaki, Osamu, Nakashima, Masato, Yoshinami, Hiroyoshi, Kase, Yasuhiro

“…We report three cases of hyper-IgG4 disease with synchronous or asynchronous lymphocytic infiltration onset, IgG4 positive plasma cell infiltration, and fibril…”
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Urine titin as a novel biomarker for Duchenne muscular dystrophy by Ishii, Misawa Niki, Nakashima, Masato, Kamiguchi, Hidenori, Zach, Neta, Kuboki, Ryosuke, Baba, Rina, Hirakawa, Takeshi, Suzuki, Kazunori, Quinton, Maria

“…•Mdx mice lacking dystrophin have elevated urine titin levels.•Treatment with an exon skipping method rescued dystrophin expression and decreased urine titin…”
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Orexin 2 receptor-selective agonist danavorexton (TAK-925) promotes wakefulness in non-human primates and healthy individuals by Evans, Rebecca, Kimura, Haruhide, Nakashima, Masato, Ishikawa, Takashi, Yukitake, Hiroshi, Suzuki, Motohisa, Hazel, James, Faessel, Hélène, Wu, Jingtao, Hang, Yaming, Alexander, Robert, Rosen, Laura, Hartman, Deborah S, Ratti, Emiliangelo

“…The orexin 2 receptor-selective agonist danavorexton (TAK-925) has been shown to produce wake-promoting effects in wild-type mice, narcolepsy-model mice, and…”
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T257. The Phosphodiesterase 2A Inhibitor TAK-915 Ameliorates Cognitive Impairments and Social Withdrawal in N-Methyl-D-Aspartate Receptor Antagonist-Induced Rat Models of Schizophrenia by Nakashima, Masato, Imada, Haruka, Shiraishi, Eri, Ito, Yuki, Suzuki, Noriko, Miyamoto, Maki, Taniguchi, Takahiko, Iwashita, Hiroki

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Regulatory mechanism of the gastric hyperemic response following barrier disruption: roles of cyclooxygenase-1, the prostaglandin E2/EP1 receptor and sensory neurons by Takeuchi, Koji, Takeeda, Masanori, Amagase, Kikuko, Nakashima, Masato

“…We herein reviewed the mechanism underlying the gastric hyperemic response following barrier disruption, with a focus on cyclooxygenase (COX) isozymes,…”
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Synthesis of a Novel Series of Tricyclic Dihydrofuran Derivatives: Discovery of 8,9-Dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridines as Melatonin Receptor (MT1/MT2) Ligands by Koike, Tatsuki, Takai, Takafumi, Hoashi, Yasutaka, Nakayama, Masaharu, Kosugi, Yohei, Nakashima, Masato, Yoshikubo, Shin-ichi, Hirai, Keisuke, Uchikawa, Osamu

“…Novel tricyclic dihydrofuran derivatives were designed, synthesized, and evaluated as melatonin receptor (MT1/MT2) ligands based on the previously reported…”
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Discovery of potent, selective, orally active benzoxazepine-based Orexin-2 receptor antagonists by Fujimoto, Tatsuhiko, Kunitomo, Jun, Tomata, Yoshihide, Nishiyama, Keiji, Nakashima, Masato, Hirozane, Mariko, Yoshikubo, Shin-ichi, Hirai, Keisuke, Marui, Shogo

“…During our efforts to identify a series of potent, selective, orally active human Orexin-2 Receptor (OX2R) antagonists, we elucidated structure-activity…”
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