Search Results - "Nakashima, Manabu"

Glypican-3 gene silencing for ovarian cancer using siRNA-PLGA hybrid micelles in a murine peritoneal dissemination model by Hazekawa, Mai, Nishinakagawa, Takuya, Kawakubo-Yasukochi, Tomoyo, Nakashima, Manabu

“…Small interfering RNA (siRNA) has received much attention and for possible therapeutic applications to treat incurable chronic and genetic diseases, including…”
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Dietary habits and behaviors associated with nonalcoholic fatty liver disease by Yasutake, Kenichiro, Kohjima, Motoyuki, Kotoh, Kazuhiro, Nakashima, Manabu, Nakamuta, Makoto, Enjoji, Munechika

“…Nonalcoholic fatty liver disease(NAFLD)is one of the most frequent causes of health problems in Western(industrialized)countries.Moreover,the incidence of…”
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In Vitro Anti-inflammatory Effects of the Phenylbutyric Acid Metabolite Phenylacetyl Glutamine by Hazekawa, Mai, Ono, Kazuhiko, Nishinakagawa, Takuya, Kawakubo-Yasukochi, Tomoyo, Nakashima, Manabu

“…Sodium 4-phenylbutyrate (PBA), which exerts a wide range of anti-inflammatory effects, is rapidly cleared from the body (approximately 98%) by urinary…”
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Assessment of Anticancer Drug Effects on Pancreatic Cancer Cells under Glucose-Depleted Conditions Using Intracellular and Extracellular Amino Acid Metabolomics by Tomita, Ryoko, Todoroki, Kenichiro, Hayama, Tadashi, Yoshida, Hideyuki, Fujioka, Toshihiro, Nakashima, Manabu, Yamaguchi, Masatoshi, Nohta, Hitoshi

“…Previously, we developed a method to evaluate states of cells treated with anticancer drugs via the comprehensive analysis of amino acids, termed amino acid…”
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Amino Acid Metabolomics Using LC-MS/MS: Assessment of Cancer-Cell Resistance in a Simulated Tumor Microenvironment by TOMITA, Ryoko, TODOROKI, Kenichiro, MARUOKA, Hiroshi, YOSHIDA, Hideyuki, FUJIOKA, Toshihiro, NAKASHIMA, Manabu, YAMAGUCHI, Masatoshi, NOHTA, Hitoshi

“…We performed a comprehensive quantification of 20 amino acids in RPMI 1640 medium-cultured human colorectal adenocarcinoma cells to evaluate the efficacy of…”
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Regulation of collagen type XVII expression by miR203a-3p in oral squamous cell carcinoma cells by Yasukochi, Atsushi, Kawakubo-Yasukochi, Tomoyo, Morioka, Masahiko, Hazekawa, Mai, Nishinakagawa, Takuya, Ono, Kazuhiko, Nakashima, Manabu, Nakamura, Seiji

“…Collagen type XVII (COL17) is expressed in various tissues and its aberrant expression is associated with tumour progression. In this study, we investigated…”
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The New Application of Real-time Cell-monitoring Analysis System to Detect Cellular Responses in Human Umbilical Vein Endothelial to Paclitaxel by Hazekawa, Mai, Nishinakagawa, Takuya, Kawakubo-Yasukochi, Tomoyo, Nakashima, Manabu

“…Although widely used in the treatment of common cancers, paclitaxel causes angialgia/phlebitis in 60–70% of patients when administered intravenously to the…”
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Orally administered sodium 4-phenylbutyrate suppresses the development of dextran sulfate sodium-induced colitis in mice by Ono, Kazuhiko, Nimura, Satoshi, Hideshima, Yuko, Nabeshima, Kazuki, Nakashima, Manabu

“…Sodium 4-phenylbutyrate (PBA) exerts therapeutic effects in a wide range of pathologies. A previous study by the present authors revealed that intraperitoneal…”
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Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1 by Watanabe, Takeshi, Nakashima, Manabu, Sonoda, Kenzo

“…Tumor-associated antigens that can be recognized by the immune system include the MAGE-family, p53, MUC-1, HER2/neu and p21ras. Despite their expression of…”
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Receptor-binding cancer antigen expressed on SiSo cells induces apoptosis via ectodomain shedding by Sonoda, Kenzo, Miyamoto, Shingo, Nakashima, Manabu, Wake, Norio

“…Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a secreted antigen that induces apoptosis in putative receptor-expressing cells, including…”
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Anti-inflammatory effects of water extract from bell pepper (Capsicum annuum L. var. grossum) leaves in vitro by Hazekawa, Mai, Hideshima, Yuko, Ono, Kazuhiko, Nishinakagawa, Takuya, Kawakubo-Yasukochi, Tomoyo, Takatani-Nakase, Tomoka, Nakashima, Manabu

“…Fruits and vegetables have been recognized as natural sources of various bioactive compounds. Peppers, one such natural source, are consumed worldwide as spice…”
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Performance Information Use in a Purpose-Oriented Network: A Relational Perspective by Nakashima, Manabu

“…Abstract Performance information use is an essential component of performance management, which is an important tool to manage purpose-oriented networks…”
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Expression profile of lipid metabolism-associated genes in hepatitis C virus-infected human liver by Fujino, Tatsuya, Nakamuta, Makoto, Yada, Ryoko, Aoyagi, Yoko, Yasutake, Kenichiro, Kohjima, Motoyuki, Fukuizumi, Kunitaka, Yoshimoto, Tsuyoshi, Harada, Naohiko, Yada, Masayoshi, Kato, Masaki, Kotoh, Kazuhiro, Taketomi, Akinobu, Maehara, Yoshihiko, Nakashima, Manabu, Enjoji, Munechika

“…Aim:  Recent studies have shown that lipid metabolic pathways are required for the entry, replication and secretion of hepatitis C virus (HCV). Although little…”
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Assessment of the Efficacy of Anticancer Drugs by Amino Acid Metabolomics Using Fluorescence Derivatization-HPLC by TOMITA, Ryoko, TODOROKI, Kenichiro, MACHIDA, Kazuyuki, NISHIDA, Sho, MARUOKA, Hiroshi, YOSHIDA, Hideyuki, FUJIOKA, Toshihiro, NAKASHIMA, Manabu, YAMAGUCHI, Masatoshi, NOHTA, Hitoshi

“…Metabolomic studies conducted for evaluating cancer pathogenesis and progression by monitoring the amino acids metabolic balance hold great promise for…”
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NPC1L1 inhibitor ezetimibe is a reliable therapeutic agent for non-obese patients with nonalcoholic fatty liver disease by Enjoji, Munechika, Machida, Kazuyuki, Kohjima, Motoyuki, Kato, Masaki, Kotoh, Kazuhiro, Matsunaga, Kazuhisa, Nakashima, Manabu, Nakamuta, Makoto

“…We recently examined the distribution of abdominal fat, dietary intake and biochemical data in patients with nonalcoholic fatty liver disease (NAFLD) and found…”
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Biologic significance of receptor‐binding cancer antigen expressed on SiSo cells (RCAS1) as a pivotal regulator of tumor growth through angiogenesis in human uterine cancer by Sonoda, Kenzo, Miyamoto, Shingo, Yamazaki, Ayano, Kobayashi, Hiroaki, Nakashima, Manabu, Mekada, Eisuke, Wake, Norio

“…BACKGROUND. The expression of receptor‐binding cancer antigen expressed on SiSo cells (RCAS1) is related significantly to the overall survival of patients with…”
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Fully automated reagent peak-free liquid chromatography fluorescence analysis of highly polar carboxylic acids using a column-switching system and fluorous scavenging derivatization by Todoroki, Kenichiro, Hashimoto, Hiroki, Machida, Kazuyuki, Itoyama, Miki, Hayama, Tadashi, Yoshida, Hideyuki, Nohta, Hitoshi, Nakashima, Manabu, Yamaguchi, Masatoshi

“…In this study, we combined a column‐switching system with a fluorous scavenging derivatization method to develop a fully automated reagent peak‐free LC…”
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Add-on therapy of pitavastatin and eicosapentaenoic acid improves outcome of peginterferon plus ribavirin treatment for chronic hepatitis C by Kohjima, Motoyuki, Enjoji, Munechika, Yoshimoto, Tsuyoshi, Yada, Ryoko, Fujino, Tatsuya, Aoyagi, Yoko, Fukushima, Nobuyoshi, Fukuizumi, Kunitaka, Harada, Naohiko, Yada, Masayoshi, Kato, Masaki, Kotoh, Kazuhiro, Nakashima, Manabu, Sakamoto, Naoya, Tanaka, Yasuhito, Nakamuta, Makoto

“…Despite the use of pegylated‐interferon (peg‐IFN) plus ribavirin combination therapy, many patients infected with hepatitis C virus (HCV)‐1b remain…”
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Nutrition Therapy for Liver Diseases Based on the Status of Nutritional Intake by Yasutake, Kenichiro, Kohjima, Motoyuki, Nakashima, Manabu, Kotoh, Kazuhiro, Nakamuta, Makoto, Enjoji, Munechika

“…The dietary intake of patients with nonalcoholic fatty liver disease (NAFLD) is generally characterized by high levels of carbohydrate, fat, and/or…”
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Adrenomedullin-induced relaxation of rat brain pericytes is related to the reduced phosphorylation of myosin light chain through the cAMP/PKA signaling pathway by Takata, Fuyuko, Dohgu, Shinya, Nishioku, Tsuyoshi, Takahashi, Hiroyuki, Harada, Eriko, Makino, Ikuko, Nakashima, Manabu, Yamauchi, Atsushi, Kataoka, Yasufumi

“…Brain pericytes are known to embrace the abluminal endothelial surfaces of cerebral microvessels. The rich expression of contractile proteins in these cells…”
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