Search Results - "Nakashima, Kazuhisa"

Tooth transplantation and replantation: Biological insights towards therapeutic improvements by Ideno, Hisashi, Komatsu, Koichiro, Nakashima, Kazuhisa, Nifuji, Akira

“…Summary Transplantation and replantation of teeth are effective therapeutic approaches for tooth repositioning and avulsion, respectively. Transplantation…”
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Platelet-derived growth factor-BB regenerates functional periodontal ligament in the tooth replantation by Komatsu, Koichiro, Ideno, Hisashi, Shibata, Tatsuya, Nakashima, Kazuhisa, Nifuji, Akira

“…Tooth ankylosis is a pathological condition of periodontal ligament (PDL) restoration after tooth replantation. Platelet-derived growth factor-BB (PDGF-BB) has…”
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Profilin-1 negatively controls osteoclast migration by suppressing the protrusive structures based on branched actin filaments by Kajikawa, Shuhei, Ezura, Yoichi, Izu, Yayoi, Nakashima, Kazuhisa, Noda, Masaki, Nifuji, Akira

“…Background Profilin-1 ( Pfn1 ), an evolutionarily conserved actin-binding protein, is an important regulator of the cytoskeleton. We previously reported the…”
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Transcriptional mechanisms in osteoblast differentiation and bone formation by Nakashima, Kazuhisa, de Crombrugghe, Benoit

“…Osteoblasts, the cells responsible for bone formation, differentiate from mesenchymal cells. Here, we discuss transcription factors that are involved in…”
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The histone H3K9 methyltransferase G9a regulates tendon formation during development by Wada, Satoshi, Ideno, Hisashi, Nakashima, Kazuhisa, Komatsu, Koichiro, Demura, Noboru, Tomonari, Hiroshi, Kimura, Hiroshi, Tachibana, Makoto, Nifuji, Akira

“…G9a is a histone methyltransferase that catalyzes the methylation of histone 3 lysine 9 (H3K9), which is involved in the regulation of gene expression. We had…”
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Rebiopsy for patients with non‐small‐cell lung cancer after epidermal growth factor receptor‐tyrosine kinase inhibitor failure by Kawamura, Takahisa, Kenmotsu, Hirotsugu, Taira, Tetsuhiko, Omori, Shota, Nakashima, Kazuhisa, Wakuda, Kazushige, Ono, Akira, Naito, Tateaki, Murakami, Haruyasu, Mori, Keita, Nakajima, Takashi, Ohde, Yasuhisa, Endo, Masahiro, Takahashi, Toshiaki

“…Although third‐generation epidermal growth factor receptor‐tyrosine kinase inhibitors (EGFR‐TKI) can overcome T790M‐mediated resistance in non‐small‐cell lung…”
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SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix by Fukuda, Masatoshi, Yoshizawa, Tatsuya, Karim, Md. Fazlul, Sobuz, Shihab U., Korogi, Wataru, Kobayasi, Daiki, Okanishi, Hiroki, Tasaki, Masayoshi, Ono, Katsuhiko, Sawa, Tomohiro, Sato, Yoshifumi, Chirifu, Mami, Masuda, Takeshi, Nakamura, Teruya, Tanoue, Hironori, Nakashima, Kazuhisa, Kobashigawa, Yoshihiro, Morioka, Hiroshi, Bober, Eva, Ohtsuki, Sumio, Yamagata, Yuriko, Ando, Yukio, Oike, Yuichi, Araki, Norie, Takeda, Shu, Mizuta, Hiroshi, Yamagata, Kazuya

“…SP7/Osterix (OSX) is a master regulatory transcription factor that activates a variety of genes during differentiation of osteoblasts. However, the influence…”
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Cytokine Release Syndrome More than Two Years after Pembrolizumab Introduction by Nakashima, Kazuhisa, Kitani, Kashu, Kono, Kento, Yoshihara, Ken, Kawakado, Keita, Kobayashi, Misato, Okuno, Takae, Amano, Yoshihiro, Tsubata, Yukari, Isobe, Takeshi

“…A 71-year-old man with advanced lung adenocarcinoma was treated with carboplatin, pemetrexed, and pembrolizumab in June 2020. Pemetrexed and pembrolizumab…”
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Osteoclast-specific Dicer gene deficiency suppresses osteoclastic bone resorption by Mizoguchi, Fumitaka, Izu, Yayoi, Hayata, Tadayoshi, Hemmi, Hiroaki, Nakashima, Kazuhisa, Nakamura, Takashi, Kato, Shigeaki, Miyasaka, Nobuyuki, Ezura, Yoichi, Noda, Masaki

“…Osteoclasts are unique cells that resorb bone, and are involved in not only bone remodeling but also pathological bone loss such as osteoporosis and rheumatoid…”
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IgA Nephropathy that Developed as an Immune-related Adverse Event of Pembrolizumab Complicated with Interstitial Nephritis by Mitarai, Yuki, Nakashima, Kazuhisa, Fukunaga, Shohei, Ishikawa, Noriyoshi, Ito, Takafumi, Tsubata, Yukari, Isobe, Takeshi

“…A 70-year-old man received pembrolizumab as a second-line treatment for squamous cell lung cancer of the lower right lobe. After three courses, proteinuria and…”
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G9a is involved in the regulation of cranial bone formation through activation of Runx2 function during development by Ideno, Hisashi, Nakashima, Kazuhisa, Komatsu, Koichiro, Araki, Ryoko, Abe, Masumi, Arai, Yoshinori, Kimura, Hiroshi, Shinkai, Yoichi, Tachibana, Makoto, Nifuji, Akira

“…The methyltransferase G9a was originally isolated as a histone methyltransferase that catalyzes the methylation of histone 3 lysine 9 (H3K9) to a dimethylated…”
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IgA Nephropathy that Developed as an Immune-related Adverse Event of Pembrolizumab Complicated with Interstitial Nephritis: A Case Study by Mitarai, Yuki, Nakashima, Kazuhisa, Fukunaga, Shohei, Ishikawa, Noriyoshi, Ito, Takafumi, Tsubata, Yukari, Isobe, Takeshi

“…A 70-year-old man received pembrolizumab as a second-line treatment for squamous cell lung cancer of the lower right lobe. After three courses, proteinuria and…”
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ALK-rearranged lung squamous cell carcinoma responding to alectinib: a case report and review of the literature by Mamesaya, Nobuaki, Nakashima, Kazuhisa, Naito, Tateaki, Nakajima, Takashi, Endo, Masahiro, Takahashi, Toshiaki

“…Although anaplastic lymphoma kinase (ALK) fusion genes are generally identified in lung adenocarcinoma patients, they are relatively rare in patients with…”
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Osimertinib for patients with poor performance status and EGFR T790M mutation-positive advanced non-small cell lung cancer: a phase II clinical trial by Nakashima, Kazuhisa, Ozawa, Yuichi, Daga, Haruko, Imai, Hisao, Tamiya, Motohiro, Tokito, Takaaki, Kawamura, Takahisa, Akamatsu, Hiroaki, Tsuboguchi, Yuko, Takahashi, Toshiaki, Yamamoto, Nobuyuki, Mori, Keita, Murakami, Haruyasu

“…Summary Osimertinib is a molecularly targeted agent used to treat non-small cell lung cancer (NSCLC) patients with an epidermal growth factor receptor (EGFR)…”
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Lung squamous cell carcinoma responding to nivolumab retreatment six years after initial treatment: A case report by Kono, Kento, Nakashima, Kazuhisa, Tsubata, Yukari, Amano, Yoshihiro, Kawakado, Keita, Yanagawa, Takashi, Isobe, Takeshi

“…A 61‐year‐old man presented to our hospital with a chief complaint of chronic cough. He was diagnosed with lung squamous cell carcinoma at clinical stage…”
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Skeletal muscle depletion during chemotherapy has a large impact on physical function in elderly Japanese patients with advanced non-small-cell lung cancer by Naito, Tateaki, Okayama, Taro, Aoyama, Takashi, Ohashi, Takuya, Masuda, Yoshiyuki, Kimura, Madoka, Shiozaki, Hitomi, Murakami, Haruyasu, Kenmotsu, Hirotsugu, Taira, Tetsuhiko, Ono, Akira, Wakuda, Kazushige, Imai, Hisao, Oyakawa, Takuya, Ishii, Takeshi, Omori, Shota, Nakashima, Kazuhisa, Endo, Masahiro, Omae, Katsuhiro, Mori, Keita, Yamamoto, Nobuyuki, Tanuma, Akira, Takahashi, Toshiaki

“…Elderly patient with advanced cancer is one of the most vulnerable populations. Skeletal muscle depletion during chemotherapy may have substantial impact on…”
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NFAT and Osterix cooperatively regulate bone formation by Takayanagi, Hiroshi, Koga, Takako, Matsui, Yuichi, Asagiri, Masataka, Kodama, Tatsuhiko, de Crombrugghe, Benoit, Nakashima, Kazuhisa

“…Immunosuppressants are crucial in the prevention of detrimental immune reactions associated with allogenic organ transplantation, but they often cause adverse…”
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The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation by Nakashima, Kazuhisa, Zhou, Xin, Kunkel, Gary, Zhang, Zhaoping, Deng, Jian Min, Behringer, Richard R., de Crombrugghe, Benoit

“…We have identified a novel zinc finger-containing transcription factor, called Osterix (Osx), that is specifically expressed in all developing bones. In Osx…”
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Nivolumab‐induced radiation recall pneumonitis in non‐small‐cell lung cancer patients with thoracic radiation therapy by Noda‐Narita, Shoko, Naito, Tomoyuki, Udagawa, Hibiki, Goto, Koichi, Miyawaki, Taichi, Mamesaya, Nobuaki, Nakashima, Kazuhisa, Kenmotsu, Hirotsugu, Shimokawaji, Tadasuke, Kato, Terufumi, Hakozaki, Taiki, Okuma, Yusuke, Nakamura, Masaki, Nakayama, Yuko, Watanabe, Hirokazu, Kusumoto, Masahiko, Ohe, Yuichiro, Horinouchi, Hidehito

“…The role of previous thoracic radiation therapy as a risk factor of immune‐related pneumonitis is unclear. Furthermore, some patients develop radiation recall…”
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Primary lung cancer with pulmonary alveolar proteinosis treated with immune checkpoint inhibitor: A case report by Horie, Mika, Nakashima, Kazuhisa, Amano, Yoshihiro, Shiratsuki, Yohei, Murakami, Kotaro, Isobe, Takeshi, Tsubata, Yukari

“…Primary lung cancer with pulmonary alveolar proteinosis (PAP) is a rare condition. We present a case of a patient with primary lung cancer with PAP treated…”
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