Search Results - "Nakasato, Yoshisuke"

Simplifying the Chemical Structure of Cationic Lipids for siRNA-Lipid Nanoparticles by Kuboyama, Takeshi, Yagi, Kaori, Naoi, Tomoyuki, Era, Tomohiro, Yagi, Nobuhiro, Nakasato, Yoshisuke, Yabuuchi, Hayato, Takahashi, Saori, Shinohara, Fumikazu, Iwai, Hiroto, Koubara-Yamada, Ayumi, Hasegawa, Kazumasa, Miwa, Atsushi

“…We report a potent cationic lipid, SST-02 ((3-hydroxylpropyl)­dilinoleylamine), which possesses a simple chemical structure and is synthesized just in one…”
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K-685, a TRPV1 Antagonist, Blocks PKC-Sensitized TRPV1 Activation and Improves the Inflammatory Pain in a Rat Complete Freund’s Adjuvant Model by Sugimoto, Yoshiyuki, Kojima, Yozo, Inayoshi, Atsushi, Inoue, Kazuaki, Miura-Kusaka, Hiroko, Mori, Kiyotoshi, Saku, Osamu, Ishida, Hiroshi, Atsumi, Eri, Nakasato, Yoshisuke, Shirakura, Shiro, Toki, Shin-ichiro, Shinoda, Katsumi, Suzuki, Nobuyuki

“…Transient receptor potential vanilloid 1 (TRPV1) is a Ca2+-permeable non-selective cation channel that transmits pain signals. TRPV1 is activated by multiple…”
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Abstract A155: Small molecule metabolic inhibitors, compound A and the derivatives specifically inhibit the cell growth of Ewing's sarcoma cells harbor EWS-FLI1 in vitro and in vivo by Kosaka, Hiromichi, Watanabe, Yasuo, Maemoto, Michihiro, Sugawara, Masamori, Watanabe, Miwa, Ono, Yoko, Nakasato, Yoshisuke, Matsubara, Masahiro, Nakai, Ryuichiro

“…Background: Ewing's sarcoma family of tumors (ESFTs) are characterized by chromosomal translocations that fuses EWSR1 gene and other types of ETS family genes…”
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Discovery of Novel 5,5-Diarylpentadienamides as Orally Available Transient Receptor Potential Vanilloid 1 (TRPV1) Antagonists by Saku, Osamu, Ishida, Hiroshi, Atsumi, Eri, Sugimoto, Yoshiyuki, Kodaira, Hiroshi, Kato, Yoshimitsu, Shirakura, Shiro, Nakasato, Yoshisuke

“…We have developed a novel and potent chemical series of 5,5-diphenylpentadienamides for targeting TRPV1 in vitro and in vivo. In this investigation, we…”
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Synthetic study of VLA-4/VCAM-1 inhibitors: Synthesis and structure–activity relationship of piperazinylphenylalanine derivatives by Saku, Osamu, Ohta, Kiminori, Arai, Eri, Nomoto, Yuji, Miura, Hiroko, Nakamura, Hiroaki, Fuse, Eiichi, Nakasato, Yoshisuke

“…To improve poor pharmacokinetic characters of the preceding VLA-4 inhibitors, novel piperazinylphenylalanine derivatives were designed and optimized for oral…”
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New Bronchodilators. II. 3H-Imidazo[4, 5-c]quinolin-4(5H)-ones by SUZUKI, Fumio, KURODA, Takeshi, HAYASHI, Hiroaki, NAKASATO, Yoshisuke, MANABE, Haruhiko, OHMORI, Kenji, KITAMURA, Shigeto

“…A series of novel 3-substituted imidazo[4, 5-c]quinolin-4(5H)-ones (2a-w) was prepared by the reaction of imidazo[4, 5-c]quinolin-4(5H)-ones (6) with several…”
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New bronchodilators. 1. 1,5-Substituted 1H-imidazo[4,5-c]quinolin-4(5H)-ones by Suzuki, Fumio, Kuroda, Takeshi, Nakasato, Yoshisuke, Manabe, Haruhiko, Ohmori, Kenji, Kitamura, Shigeto, Ichikawa, Shunji, Ohno, Tetsuji

“…A series of novel xanthine-based tricyclic heterocycles in 1H-imidazo[4,5-c]quinolin-4(5H)-ones was designed, synthesized, and tested as potential active…”
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