Search Results - "Nakao, Kazuwa"

Translational science: Newly emerging science in biology and medicine — Lessons from translational research on the natriuretic peptide family and leptin by NAKAO, Kazuwa

“…Translation is the process of turning observations in the laboratory, clinic, and community into interventions that improve the health of individuals and the…”
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Current biochemistry, molecular biology, and clinical relevance of natriuretic peptides by Nishikimi, Toshio, MD, PhD, FJCC, Kuwahara, Koichiro, MD, PhD, Nakao, Kazuwa, MD, PhD

“…Summary The mammalian natriuretic peptide family consists of atrial (ANP), brain [B-type; BNP] and C-type natriuretic peptide (CNP) and three receptors,…”
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Transcriptional Regulation of the Fetal Cardiac Gene Program by Kuwahara, Koichiro, Nishikimi, Toshio, Nakao, Kazuwa

“…Reactivation of the fetal cardiac gene program in adults is a reliable marker of cardiac hypertrophy and heart failure. Normally, genes within this group are…”
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Phase angle from bioelectrical impedance analysis is a useful indicator of muscle quality by Akamatsu, Yasunori, Kusakabe, Toru, Arai, Hiroshi, Yamamoto, Yuji, Nakao, Kazuwa, Ikeue, Kentaro, Ishihara, Yuki, Tagami, Tetsuya, Yasoda, Akihiro, Ishii, Kojiro, Satoh‐Asahara, Noriko

“…Background Methods that facilitate muscle quality measurement may improve the diagnosis of sarcopenia. Current research has focused on the phase angle (PhA)…”
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Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice by Nishio, Miki, Sugimachi, Keishi, Goto, Hiroki, Wang, Jia, Morikawa, Takumi, Miyachi, Yosuke, Takano, Yusuke, Hikasa, Hiroki, Itoh, Tohru, Suzuki, Satoshi O., Kurihara, Hiroki, Aishima, Shinichi, Leask, Andrew, Sasaki, Takehiko, Nakano, Toru, Nishina, Hiroshi, Nishikawa, Yuji, Sekido, Yoshitaka, Nakao, Kazuwa, Shin-ya, Kazuo, Mimori, Koshi, Suzuki, Akira

“…Mps One Binder Kinase Activator (MOB)1A/1B are core components of the Hippo pathway that coactivate large tumor suppressor homolog (LATS) kinases. Mob1a/1b…”
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Effectiveness of nationwide screening and lifestyle intervention for abdominal obesity and cardiometabolic risks in Japan: The metabolic syndrome and comprehensive lifestyle intervention study on nationwide database in Japan (MetS ACTION-J study) by Nakao, Yoko M, Miyamoto, Yoshihiro, Ueshima, Kenji, Nakao, Kazuhiro, Nakai, Michikazu, Nishimura, Kunihiro, Yasuno, Shinji, Hosoda, Kiminori, Ogawa, Yoshihiro, Itoh, Hiroshi, Ogawa, Hisao, Kangawa, Kenji, Nakao, Kazuwa

“…Lifestyle interventions can substantially improve obesity and cardiometabolic risks. However, evidence of long-term benefits of national intervention is…”
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Epidemiological study of gastroenteropancreatic neuroendocrine tumors in Japan by Ito, Tetsuhide, Sasano, Hironobu, Tanaka, Masao, Osamura, R. Yoshiyuki, Sasaki, Iwao, Kimura, Wataru, Takano, Koji, Obara, Takao, Ishibashi, Miyuki, Nakao, Kazuwa, Doi, Ryuichiro, Shimatsu, Akira, Nishida, Toshirou, Komoto, Izumi, Hirata, Yukio, Nakamura, Kazuhiko, Igarashi, Hisato, Jensen, Robert T, Wiedenmann, Bertram, Imamura, Masayuki

“…Background There have been few epidemiological studies on gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in Japan. Methods We examined the…”
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CRISPR/Cas9-mediated Angptl8 knockout suppresses plasma triglyceride concentrations and adiposity in rats by Izumi, Ryota, Kusakabe, Toru, Noguchi, Michio, Iwakura, Hiroshi, Tanaka, Tomohiro, Miyazawa, Takashi, Aotani, Daisuke, Hosoda, Kiminori, Kangawa, Kenji, Nakao, Kazuwa

“…Angiopoietin-like protein (ANGPTL)8 is a liver- and adipocyte-derived protein that controls plasma triglyceride (TG) levels. Most animal studies have used…”
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New Molecular Mechanisms for Cardiovascular Disease: Transcriptional Pathways and Novel Therapeutic Targets in Heart Failure by Kuwahara, Koichiro, Nakao, Kazuwa

“…Genetic remodeling contributes to the progression of heart failure by affecting myocardial cellular function and survival. In our investigation of the…”
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Regulation and significance of atrial and brain natriuretic peptides as cardiac hormones by Kuwahara, Koichiro, Nakao, Kazuwa

“…Atrial and brain natriuretic peptides (ANP and BNP, respectively) are cardiac hormones. During cardiac development, their expression is a maker of…”
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Secreted protein lipocalin‐2 promotes microglial M1 polarization by Jang, Eunha, Lee, Shinrye, Kim, Jong‐Heon, Kim, Jae‐Hong, Seo, Jung‐Wan, Lee, Won‐Ha, Mori, Kiyoshi, Nakao, Kazuwa, Suk, Kyoungho

“…Activated macrophages are classified into two different forms: classically activated (M1) or alternatively activated (M2) macrophages. The presence of M1/M2…”
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Natriuretic Peptides/cGMP/cGMP-Dependent Protein Kinase Cascades Promote Muscle Mitochondrial Biogenesis and Prevent Obesity by MIYASHITA, Kazutoshi, ITOH, Hiroshi, NAKAO, Kazuwa, TSUJIMOTO, Hirokazu, TAMURA, Naohisa, FUKUNAGA, Yasutomo, SONE, Masakatsu, YAMAHARA, Kenichi, TAURA, Daisuke, INUZUKA, Megumi, SONOYAMA, Takuhiro

“…Natriuretic Peptides/cGMP/cGMP-Dependent Protein Kinase Cascades Promote Muscle Mitochondrial Biogenesis and Prevent Obesity Kazutoshi Miyashita 1 , Hiroshi…”
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Role of leptin in conditioned place preference to high-fat diet in leptin-deficient ob/ob mice by Shimizu, Yoshiyuki, Son, Cheol, Aotani, Daisuke, Nomura, Hidenari, Hikida, Takatoshi, Hosoda, Kiminori, Nakao, Kazuwa

“…•Conditioned place preference for a high fat diet was examined among ob/ob mice.•Higher place preference for a high fat diet was shown in ob/ob mice.•Leptin…”
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Natriuretic peptide system: an overview of studies using genetically engineered animal models by Kishimoto, Ichiro, Tokudome, Takeshi, Nakao, Kazuwa, Kangawa, Kenji

“…The mammalian natriuretic peptide system, consisting of at least three ligands and three receptors, plays critical roles in health and disease. Examination of…”
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Increase of Total Nephron Albumin Filtration and Reabsorption in Diabetic Nephropathy by Mori, Keita P, Yokoi, Hideki, Kasahara, Masato, Imamaki, Hirotaka, Ishii, Akira, Kuwabara, Takashige, Koga, Kenichi, Kato, Yukiko, Toda, Naohiro, Ohno, Shoko, Kuwahara, Koichiro, Endo, Tomomi, Nakao, Kazuwa, Yanagita, Motoko, Mukoyama, Masashi, Mori, Kiyoshi

“…The amount of albumin filtered through the glomeruli and reabsorbed at the proximal tubules in normal and in diabetic kidneys is debated. The megalin/cubilin…”
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Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons by Kuwabara, Takashige, Mori, Kiyoshi, Mukoyama, Masashi, Kasahara, Masato, Yokoi, Hideki, Saito, Yoko, Yoshioka, Tetsuro, Ogawa, Yoshihisa, Imamaki, Hirotaka, Kusakabe, Toru, Ebihara, Ken, Omata, Mitsugu, Satoh, Noriko, Sugawara, Akira, Barasch, Jonathan, Nakao, Kazuwa

“…Urinary neutrophil gelatinase-associated lipocalin (Ngal or lipocalin 2) is a very early and sensitive biomarker of kidney injury. Here we determined the…”
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Practice guideline for lipodystrophy syndromes—clinically important diseases of the Japan Endocrine Society (JES) by Tanaka, Tomohiro, Kusakabe, Toru, Ebihara, Ken, Aizawa-Abe, Megumi, Aotani, Daisuke, Yorifuji, Tohru, Satoh, Mari, Ogawa, Yoshihiro, Nakao, Kazuwa

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Endothelium-Derived C-Type Natriuretic Peptide Contributes to Blood Pressure Regulation by Maintaining Endothelial Integrity by Nakao, Kazuhiro, Kuwahara, Koichiro, Nishikimi, Toshio, Nakagawa, Yasuaki, Kinoshita, Hideyuki, Minami, Takeya, Kuwabara, Yoshihiro, Yamada, Chinatsu, Yamada, Yuko, Tokudome, Takeshi, Nagai-Okatani, Chiaki, Minamino, Naoto, Nakao, Yoko M, Yasuno, Shinji, Ueshima, Kenji, Sone, Masakatsu, Kimura, Takeshi, Kangawa, Kenji, Nakao, Kazuwa

“…We previously reported the secretion of C-type natriuretic peptide (CNP) from vascular endothelial cells and proposed the existence of a vascular natriuretic…”
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Induction and Isolation of Vascular Cells From Human Induced Pluripotent Stem Cells—Brief Report by Taura, Daisuke, Sone, Masakatsu, Homma, Koichiro, Oyamada, Naofumi, Takahashi, Kazutoshi, Tamura, Naohisa, Yamanaka, Shinya, Nakao, Kazuwa

“…OBJECTIVE—Induced pluripotent stem (iPS) cells are a novel stem cell population derived from human adult somatic cells through reprogramming using a defined…”
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The association between uric acid levels and renal function of CKD patients with hyperlipidemia: a sub-analysis of the ASUCA trial by Kuwabara, Yoshihiro, Yasuno, Shinji, Kasahara, Masato, Ueshima, Kenji, Nakao, Kazuwa

“…Background The influence of uric acid (UA) on renal function and the significance of UA-lowering therapy are unclear. The purpose of the sub-analysis of the…”
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