Search Results - "Nakano, Stephanie"

Heart failure in single right ventricle congenital heart disease: physiological and molecular considerations by Garcia, Anastacia M, Beatty, Jonathan-Thomas, Nakano, Stephanie J

“…Because of remarkable surgical and medical advances over the past several decades, there are growing numbers of infants and children living with single…”
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Beyond the biopsy: Is it time to change the gold standard for rejection diagnosis in clinical decision-making and scientific discovery? by Nakano, Stephanie J., Everitt, Melanie D.

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A PDE3A Promoter Polymorphism Regulates cAMP-Induced Transcriptional Activity in Failing Human Myocardium by Sucharov, Carmen C., Nakano, Stephanie J., Slavov, Dobromir, Schwisow, Jessica A., Rodriguez, Erin, Nunley, Karin, Medway, Allen, Stafford, Natalie, Nelson, Penny, McKinsey, Timothy A., Movsesian, Matthew, Minobe, Wayne, Carroll, Ian A., Taylor, Matthew R.G., Bristow, Michael R.

“…The phosphodiesterase 3A (PDE3A) gene encodes a PDE that regulates cardiac myocyte cyclic adenosine monophosphate (cAMP) levels and myocardial contractile…”
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Pediatric Heart Failure: An Evolving Public Health Concern by Nakano, Stephanie J., Miyamoto, Shelley D., Price, Jack F., Rossano, Joseph W., Cabrera, Antonio G.

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Elevated serum vascular endothelial growth factor and development of cardiac allograft vasculopathy in children by Watanabe, Kae, Karimpour-Fard, Anis, Michael, Alix, Miyamoto, Shelley D., Nakano, Stephanie J.

“…Cardiac allograft vasculopathy (CAV) is a leading cause of retransplantation and death in pediatric heart transplant recipients. Our aim was to evaluate the…”
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Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment by Nakano, Stephanie J., MD, Sucharov, Juliana, van Dusen, Robert, BS, Cecil, Mackenzie, Nunley, Karin, MS, Wickers, Sean, Karimpur-Fard, Anis, PhD, Stauffer, Brian L., MD, Miyamoto, Shelley D., MD, Sucharov, Carmen C., PhD

“…Abstract Background Pediatric heart failure (HF) patients have a suboptimal response to traditional HF medications, although phosphodiesterase-3 inhibition…”
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Myocardial Response to Milrinone in Single Right Ventricle Heart Disease by Nakano, Stephanie J., MD, Nelson, Penny, MS, Sucharov, Carmen C., PhD, Miyamoto, Shelley D., MD

“…Objectives Empiric treatment with milrinone, a phosphodiesterase (PDE) 3 inhibitor, has become increasingly common in patients with single ventricle heart…”
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Risk factors for lethal arrhythmic events in children and adolescents with hypertrophic cardiomyopathy and an implantable defibrillator: An international multicenter study by Balaji, Seshadri, DiLorenzo, Michael P., Fish, Frank A., Etheridge, Susan P., Aziz, Peter F., Russell, Mark W., Tisma, Svjetlana, Pflaumer, Andreas, Sreeram, Narayanswami, Kubus, Peter, Law, Ian H., Kantoch, Michal J., Kertesz, Naomi J., Strieper, Margaret, Erickson, Christopher C., Moore, Jeremy P., Nakano, Stephanie J., Singh, Harinder R., Chang, Philip, Cohen, Mitchell, Fournier, Anne, Ilina, Maria V., Smith, Richard T., Zimmerman, Frank, Horndasch, Michaela, Li, Walter, Batra, Anjan, Liberman, Leonardo, Hamilton, Robert, Janson, Christopher M., Sanatani, Shubhayan, Zeltser, Ilana, McDaniel, George, Blaufox, Andrew D., Garnreiter, Jason M., Katcoff, Hannah, Shah, Maully

“…Predictors of risk of lethal arrhythmic events (LAE) is poorly understood and may differ from adults in children with hypertrophic cardiomyopathy (HCM). The…”
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A novel GNAS variant presents with disorders of GNAS inactivation and cardiomyopathy by Shelkowitz, Emily, Chan, Christine M., Jones, Tonya, Nakano, Stephanie J., Meeks, Naomi J. L.

“…The GNAS gene (OMIM#139320), located on chromosome 20q13.2, encodes for the alpha‐subunit of the stimulatory signaling protein, Gsα protein. GNAS variants with…”
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General pediatric care for a patient after heart transplant: what the practitioner needs to know by Chatfield, Kathryn, Nakano, Stephanie J, Everitt, Melanie D

“…The scope of this review is to discuss aspects of general pediatric care which significantly impact the outcome of children after heart transplant. The general…”
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Risk of Sudden Death in Patients With RASopathy Hypertrophic Cardiomyopathy by Lynch, Aine, Tatangelo, Mark, Ahuja, Sachin, Steve Fan, Chun-Po, Min, Sandar, Lafreniere-Roula, Myriam, Papaz, Tanya, Zhou, Vivian, Armstrong, Kathryn, Aziz, Peter F., Benson, Lee N., Butts, Ryan, Dragulescu, Andreea, Gardin, Letizia, Godown, Justin, Jeewa, Aamir, Kantor, Paul F., Kaufman, Beth D., Lal, Ashwin K., Parent, John J., Richmond, Marc, Russell, Mark W., Balaji, Seshadri, Stephenson, Elizabeth A., Villa, Chet, Jefferies, John L., Whitehill, Robert, Conway, Jennifer, Howard, Taylor S., Nakano, Stephanie J., Rossano, Joseph, Weintraub, Robert G., Mital, Seema

“…Genetic defects in the RAS/mitogen-activated protein kinase pathway are an important cause of hypertrophic cardiomyopathy (RAS-HCM). Unlike primary HCM…”
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Increased myocyte calcium sensitivity in end-stage pediatric dilated cardiomyopathy by Nakano, Stephanie J, Walker, John S, Walker, Lori A, Li, Xiaotao, Du, Yanmei, Miyamoto, Shelley D, Sucharov, Carmen C, Garcia, Anastacia M, Mitchell, Max B, Ambardekar, Amrut V, Stauffer, Brian L

“…Dilated cardiomyopathy (DCM) is the most common cause of heart failure (HF) in children, resulting in high mortality and need for heart transplantation. The…”
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Phosphodiesterase-5 Is Elevated in Failing Single Ventricle Myocardium and Affects Cardiomyocyte Remodeling In Vitro by Garcia, Anastacia M, Nakano, Stephanie J, Karimpour-Fard, Anis, Nunley, Karin, Blain-Nelson, Penny, Stafford, Natalie M, Stauffer, Brian L, Sucharov, Carmen C, Miyamoto, Shelley D

“…Background Single ventricle (SV) congenital heart disease is fatal without intervention, and eventual heart failure is a major cause of morbidity and…”
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Age-related differences in phosphodiesterase activity and effects of chronic phosphodiesterase inhibition in idiopathic dilated cardiomyopathy by Nakano, Stephanie J, Miyamoto, Shelley D, Movsesian, Matthew, Nelson, Penny, Stauffer, Brian L, Sucharov, Carmen C

“…Despite the application of proven adult heart failure therapies to children with idiopathic dilated cardiomyopathy (IDC), prognosis remains poor. Clinical…”
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Ex vivo Methods for Measuring Cardiac Muscle Mechanical Properties by Knight, Walter E, Ali, Hadi R, Nakano, Stephanie J, Wilson, Cortney E, Walker, Lori A, Woulfe, Kathleen C

“…Cardiovascular disease continues to be the leading cause of morbidity and mortality in the United States and thousands of manuscripts each year are aimed at…”
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Patterns of Electrocardiographic Abnormalities in Children with Hypertrophic Cardiomyopathy by Marshall, Mayme, Malik, Aneeq, Shah, Maully, Fish, Frank A., Etheridge, Susan P., Aziz, Peter F., Russell, Mark W., Tisma, Svjetlana, Pflaumer, Andreas, Sreeram, Narayanswami, Kubus, Peter, Law, Ian H., Kantoch, Michal J., Kertesz, Naomi J., Strieper, Margaret, Erickson, Christopher C., Moore, Jeremy P., Nakano, Stephanie J., Singh, Harinder R., Chang, Philip, Cohen, Mitchell, Fournier, Anne, Ilina, Maria V., Zimmermann, Frank, Horndasch, Michaela, Li, Walter, Batra, Anjan S., Liberman, Leonardo, Hamilton, Robert, Janson, Christopher M., Sanatani, Shubhayan, Zeltser, Ilana, McDaniel, George, Blaufox, Andrew D., Garnreiter, Jason M., Balaji, Seshadri

“…Hypertrophic cardiomyopathy (HCM), a common cardiomyopathy in children, is an important cause of morbidity and mortality. Early recognition and appropriate…”
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Fibrosis-Related Gene Expression in Single Ventricle Heart Disease by Nakano, Stephanie J., Siomos, Austine K., Garcia, Anastacia M., Nguyen, Hieu, SooHoo, Megan, Galambos, Csaba, Nunley, Karin, Stauffer, Brian L., Sucharov, Carmen C., Miyamoto, Shelley D.

“…To evaluate fibrosis and fibrosis-related gene expression in the myocardium of pediatric subjects with single ventricle with right ventricular failure…”
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Risk stratification in pediatric hypertrophic cardiomyopathy: Insights for bridging the evidence gap? by Nakano, Stephanie J., Menon, Shaji C.

“…Identification of children with hypertrophic cardiomyopathy (HCM) who are at high risk for sudden cardiac death (SCD) remains challenging. Although a large…”
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Circulating cyclic adenosine monophosphate concentrations in milrinone treated paediatric patients after congenital heart surgery by Gist, Katja M, Korst, Armin, Nakano, Stephanie J, Stauffer, Brian L, Karimpour-Fard, Anis, Zhou, Wenru, Campbell, Kristen, Wempe, Michael F, Sucharov, Carmen C, Miyamoto, Shelley D

“…Milrinone is a phosphodiesterase type 3 inhibitor that results in a positive inotropic effect in the heart through an increase in cyclic adenosine…”
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Educational and learning morbidity in pediatric heart transplant recipients: A pediatric heart transplant society study by Brosbe, Micah S., Wright, Lydia K., Cantor, Ryan, Dreyer, William J., Kirmani, Sonya, Knight, Margaret, Nakano, Stephanie J., Kindel, Steven J., Ryan, Thomas D., Kirklin, James K., Deshpande, Shriprasad R.

“…Educational development is an important component of quality of life for children with heart transplant. Aims include determining prevalence of and risk…”
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