Stimulation of nerve growth factor (NGF) synthesis by tryptophan and its metabolites in cultured mouse astroglial cells

Effects of l-tryptophan and its metabolites were evaluated on synthesis of nerve growth factor (NGF) in cultured mouse astroglial cells. l-Tryptophan stimulated NGF production in a dose-dependent fashion. Serotonin and quinolinic acid slightly increased NGF synthesis. l-Kynurenine had a marked stimu...

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Bibliographic Details
Published in:	Bioscience, biotechnology, and biochemistry Vol. 58; no. 11; pp. 2116 - 2117
Main Authors:	Nakano, K. (Nagoya Univ. (Japan)), Kondo, H, Hattori, M, Tsubouchi, S, Furukawa, S
Format:	Journal Article
Language:	English
Published:	Tokyo Taylor & Francis 1994 Japan Society for Bioscience Biotechnology and Agrochemistry Oxford University Press
Subjects:	ALIMENTOS Analytical, structural and metabolic biochemistry ANIMAL GROWTH PROMOTERS Biological and medical sciences FOODS Fundamental and applied biological sciences. Psychology MICE NERVOUS SYSTEM DISEASES PRODUIT ALIMENTAIRE PROMOTEUR DE CROISSANCE ANIMALE PROMOTORES DEL CRECIMIENTO ANIMAL Protein hormones. Growth factors. Cytokines Proteins RATON SOURIS TRASTORNOS DEL SISTEMA NERVIOSO TRIPTOFANO TROUBLE DU SYSTEME NERVEUX TRYPTOPHAN TRYPTOPHANE Metabolite Rodentia Tryptophan Nerve growth factor Biosynthesis In vitro Vertebrata Mammalia Astroglia Mouse Polypeptide Metabolic activation Growth factor
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Summary:	Effects of l-tryptophan and its metabolites were evaluated on synthesis of nerve growth factor (NGF) in cultured mouse astroglial cells. l-Tryptophan stimulated NGF production in a dose-dependent fashion. Serotonin and quinolinic acid slightly increased NGF synthesis. l-Kynurenine had a marked stimulatory effect on NGF synthesis at a dose of 100 μm. In contrast, kynurenic acid had no effect.
Bibliography:	S20 S30 9501597
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.58.2116