Search Results - "Nakanishi, Tsuyoshi"

Endocrine disruption induced by organotin compounds; organotins function as a powerful agonist for nuclear receptors rather than an aromatase inhibitor by Nakanishi, Tsuyoshi

“…Organotin compounds have been widely used as antifouling biocides for ships and fishing nets, agricultural fungicides and rodent repellents. These widespread…”
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Maternal Transfer of 2‑Ethylhexyl Diphenyl Phosphate Leads to Developmental Toxicity Possibly by Blocking the Retinoic Acid Receptor and Retinoic X Receptor in Japanese Medaka (Oryzias latipes) by Li, Yu, Ma, Haojia, Chen, Ruichao, Zhang, Hong, Nakanishi, Tsuyoshi, Hu, Jianying

“…2-Ethylhexyl diphenyl phosphate (EHDPP) has been detected in wild fish with high concentrations, which may pose a risk in the embryo development considering…”
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Evaluation of the Estrogenic Action Potential of Royal Jelly by Genomic Signaling Pathway in Vitro and in Vivo by Ishida, Keishi, Matsumaru, Daisuke, Shimizu, Shinya, Hiromori, Youhei, Nagase, Hisamitsu, Nakanishi, Tsuyoshi

“…Royal jelly (RJ) has beneficial effects on human health, and some of these effects are reported to be the result of its estrogenic activity; however, chemicals…”
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Cadmium inhibits forskolin-induced differentiation of human placental BeWo cells by Ogushi, Shoko, Nakanishi, Tsuyoshi, Kimura, Tomoki

“…Cadmium (Cd) is an environmental pollutant. Blood Cd levels in pregnant women have been associated with premature births, infant birth size, placenta previa,…”
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Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway by Yamamoto, Takehiro, Takano, Naoharu, Ishiwata, Kyoko, Ohmura, Mitsuyo, Nagahata, Yoshiko, Matsuura, Tomomi, Kamata, Aki, Sakamoto, Kyoko, Nakanishi, Tsuyoshi, Kubo, Akiko, Hishiki, Takako, Suematsu, Makoto

“…Haem oxygenase (HO)-1/carbon monoxide (CO) protects cancer cells from oxidative stress, but the gas-responsive signalling mechanisms remain unknown. Here we…”
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Fluorene-9-bisphenol is anti-oestrogenic and may cause adverse pregnancy outcomes in mice by Zhang, Zhaobin, Hu, Ying, Guo, Jilong, Yu, Tong, Sun, Libei, Xiao, Xuan, Zhu, Desheng, Nakanishi, Tsuyoshi, Hiromori, Youhei, Li, Junyu, Fan, Xiaolin, Wan, Yi, Cheng, Siyu, Li, Jun, Guo, Xuan, Hu, Jianying

“…Bisphenol A (BPA) is used in the production of plastic but has oestrogenic activity. Therefore, BPA substitutes, such as fluorene-9-bisphenol (BHPF), have been…”
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CpG Site-Specific Regulation of Metallothionein-1 Gene Expression by Ogushi, Shoko, Yoshida, Yuya, Nakanishi, Tsuyoshi, Kimura, Tomoki

“…Metal-binding inducible proteins called metallothioneins (MTs) protect cells from heavy-metal toxicity. Their transcription is regulated by metal response…”
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Novel, highly sensitive, in vivo screening method detects estrogenic activity at low doses of bisphenol A by Ishida, Keishi, Furukawa, Motoshi, Kunitani, Masataka, Yamagiwa, Rai, Hiromori, Youhei, Matsumaru, Daisuke, Hu, Jianying, Nagase, Hisamitsu, Nakanishi, Tsuyoshi

“…Low doses of bisphenol A (BPA), a typical endocrine-disrupting chemical (EDC), have been reported to exhibit estrogenic action in animals; however, the effects…”
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Triphenyl phosphate delayed pubertal timing and induced decline of ovarian reserve in mice as an estrogen receptor antagonist by Ma, Haojia, Ishida, Keishi, Xu, Chenke, Takahashi, Kyosuke, Li, Yu, Zhang, Chenhao, Kang, Qiyue, Jia, Yingting, Hu, Wenxin, Matsumaru, Daisuke, Nakanishi, Tsuyoshi, Hu, Jianying

“…Although concerns have been raised about the adverse effects of triphenyl phosphate (TPhP) on female fertility, its risk to ovarian functioning remains…”
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Neuronal differentiation reporter mice as a new methodology for detecting in vivo developmental neurotoxicity by Ishida, Keishi, Tatsumi, Kanoko, Minamigawa, Yoshiki, Mori, Kazuma, Matsumaru, Daisuke, Nagase, Hisamitsu, Kanda, Yasunari, Takuma, Kazuhiro, Nakanishi, Tsuyoshi

“…[Display omitted] Current in vivo developmental neurotoxicity (DNT) tests are not performed routinely for chemical risk assessment because they are time and…”
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Exposure to the Organophosphate Pesticide Fenitrothion Directly Induced Defects in Mouse Embryonic External Genitalia by Acebedo, Alvin R, Alcantara, Mellissa C, Nakanishi, Tsuyoshi, Ogawa, Takehiko, Yamada, Gen, Suzuki, Kentaro

“…Many industrial chemicals have been reported as antiandrogenic substances. Exposure to these substances represents a potential risk to human health,…”
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Long-term cadmium exposure enhances metallothionein-1 induction after subsequent exposure to high concentrations of cadmium in P1798 mouse lymphosarcoma cells by Kimura, Tomoki, Hosaka, Takuomi, Nakanishi, Tsuyoshi, Aozasa, Osamu

“…Cadmium, a ubiquitous heavy metal, is a toxic industrial and environmental pollutant. The initial biological response to cadmium exposure is induction of…”
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Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway by Morikawa, Takayuki, Kajimura, Mayumi, Nakamura, Tomomi, Hishiki, Takako, Nakanishi, Tsuyoshi, Yukutake, Yoshinori, Nagahata, Yoshiko, Ishikawa, Mami, Hattori, Katsuji, Takenouchi, Toshiki, Takahashi, Takao, Ishii, Isao, Matsubara, Kazuko, Kabe, Yasuaki, Uchiyama, Shinichiro, Nagata, Eiichiro, Gadalla, Moataz M, Snyder, Solomon H, Suematsu, Makoto

“…Enhancement of cerebral blood flow by hypoxia is critical for brain function, but signaling systems underlying its regulation have been unclear. We report a…”
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Genomic integration and ligand-dependent activation of the human estrogen receptor α in the crustacean Daphnia magna by Törner, Kerstin, Nakanishi, Tsuyoshi, Matsuura, Tomoaki, Kato, Yasuhiko, Watanabe, Hajime

“…The freshwater crustacean Daphnia have a long history in water quality assessments and now lend themselves to detection of targeted chemicals using genetically…”
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Evaluation of the Skin-Sensitizing Potential of Brazilian Green Propolis by Shiraishi, Erina, Ishida, Keishi, Matsumaru, Daisuke, Ido, Akiko, Hiromori, Youhei, Nagase, Hisamitsu, Nakanishi, Tsuyoshi

“…Propolis is a resinous mixture produced by bees from their secretions and plant material, so its composition varies depending on its botanical origin. Propolis…”
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Fake metabolomics chromatogram generation for facilitating deep learning of peak-picking neural networks by Kanazawa, Shinji, Noda, Akira, Ito, Arisa, Hashimoto, Kyoko, Kunisawa, Akihiro, Nakanishi, Tsuyoshi, Kajihara, Shigeki, Mukai, Norio, Iida, Junko, Fukusaki, Eiichiro, Matsuda, Fumio

“…Finding peaks in chromatograms and determining their start and end points (peak picking) is a core task in chromatography based biotechnology. Construction of…”
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In vivo profiling of 2,3,7,8-tetrachlorodibenzo-p-dioxin–induced estrogenic/anti-estrogenic effects in female estrogen-responsive reporter transgenic mice by Yoshida, Ichiro, Ishida, Keishi, Yoshikawa, Hiroshi, Kitamura, Sho, Hiromori, Youhei, Nishioka, Yasushi, Ido, Akiko, Kimura, Tomoki, Nishikawa, Jun-ichi, Hu, Jianying, Nagase, Hisamitsu, Nakanishi, Tsuyoshi

“…[Display omitted] •We established an improved reporter mouse for examining estrogenic chemicals.•Our reporter mouse is specific for estrogenic signaling.•When…”
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Structure-Dependent Activity of Phthalate Esters and Phthalate Monoesters Binding to Human Constitutive Androstane Receptor by Zhang, Hong, Zhang, Zhaobin, Nakanishi, Tsuyoshi, Wan, Yi, Hiromori, Youhei, Nagase, Hisamistu, Hu, Jianying

“…The present study investigated the human constitutive androstane receptor (CAR) binding activities of 23 phthalate esters and 10 phthalate monoesters using a…”
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Potential Interference of Oil Vehicles on Genital Tubercle Development during the Fetal Period in ICR Mice by Nishioka, Yasushi, Tamai, Kazuki, Onda, Masanari, Hiromori, Youhei, Kimura, Tomoki, Hu, Jianying, Nagase, Hisamitsu, Nakanishi, Tsuyoshi

“…Corn oil, sesame oil, and 10% ethanol in corn oil are commonly used as dosing vehicles in toxicology studies. Since these vegetable oils contain bioactive…”
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Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle by Suhara, Tomohiro, Hishiki, Takako, Kasahara, Masataka, Hayakawa, Noriyo, Oyaizu, Tomoko, Nakanishi, Tsuyoshi, Kubo, Akiko, Morisaki, Hiroshi, Kaelin, William G., Suematsu, Makoto, Minamishima, Yoji Andrew

“…Loss of prolyl hydroxylase 2 (PHD2) activates the hypoxia-inducible factor-dependent hypoxic response, including anaerobic glycolysis, which causes large…”
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