Anticoagulant-Induced Pseudothrombocytopenia Occurring after Transcatheter Arterial Embolization for Hepatocellular Carcinoma

Pseudothrombocytopenia (PTCP) is the in vitro phenomenon of anticoagulant-activated platelet agglutination that results in spuriously low platelet counts. We report the case of a 65-year-old man with EDTA- and sodium citrate-dependent PTCP occurring after transcatheter arterial embolization (TAE) fo...

Full description

Saved in:

Bibliographic Details
Published in:	Japanese journal of clinical oncology Vol. 36; no. 8; pp. 527 - 531
Main Authors:	Yoshikawa, Takeshi, Nakanishi, Kayo, Maruta, Tsutomu, Takenaka, Daisuke, Hirota, Shozo, Matsumoto, Shinichi, Saigo, Katsuyasu, Ohno, Yoshiharu, Fujii, Masahiko, Sugimura, Kazuro
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01-08-2006 Oxford Publishing Limited (England)
Subjects:	Aged Antibiotics, Antineoplastic - administration & dosage Anticoagulants - adverse effects Blood Platelets - drug effects Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - therapy Disseminated Intravascular Coagulation - diagnosis Edetic Acid - adverse effects Embolization, Therapeutic - adverse effects Epirubicin - administration & dosage Hepatitis C - complications hepatocellular carcinoma Humans Liver Cirrhosis - complications Liver Neoplasms - blood Liver Neoplasms - pathology Liver Neoplasms - therapy Male Neoplasm Invasiveness Platelet Count portal invasion Portal Vein - pathology pseudothrombocytopenia Thrombocytopenia - diagnosis Thrombocytopenia - etiology transcatheter arterial embolization
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Pseudothrombocytopenia (PTCP) is the in vitro phenomenon of anticoagulant-activated platelet agglutination that results in spuriously low platelet counts. We report the case of a 65-year-old man with EDTA- and sodium citrate-dependent PTCP occurring after transcatheter arterial embolization (TAE) for hepatocellular carcinoma (HCC) due to hepatitis C cirrhosis. Invasion of the portal and hepatic veins by HCC formed severe trans-tumoral arterio-venous shunts that were effectively treated by TAE. Two days after the therapy, PTCP was seen on blood count and continued for 4 months. The patient received unnecessary treatment for disseminated intravascular coagulation (DIC) until the diagnosis of PTCP was established. PTCP is a rare complication but should be considered after TAE for HCC; lack of recognition may lead the physician to misdiagnosis and patient mismanagement.
Bibliography:	local:hyl054 ark:/67375/HXZ-3T2Z8QFK-V For reprints and all correspondence: Takeshi Yoshikawa, Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuoku, Kobe, Hyogo 650-0017, Japan; E-mail: yoshikaw@med.kobe-u.ac.jp istex:EDAA9CF0727B1B39F811527CE8AEEF7D3E005D68 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0368-2811 1465-3621
DOI:	10.1093/jjco/hyl054