Search Results - "Nakamura, Takahiro J."
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An Exploratory Randomized Controlled Study to Investigate Concentration-Dependence of Green Tea Catechin Gargling on Acute Upper Respiratory Tract Infections
Published in Biological & pharmaceutical bulletin (23-07-2024)“…Green tea (GT) catechins exhibit antiviral effects in experimental studies. However, we lack clinical evidence on the preventive effects of catechin…”
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Suppression of Blue Light at Night Ameliorates Metabolic Abnormalities by Controlling Circadian Rhythms
Published in Investigative ophthalmology & visual science (03-09-2019)“…Light-emitting diodes that emit high-intensity blue light are associated with blue-light hazard. Here, we report that blue light disturbs circadian rhythms by…”
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GABA from vasopressin neurons regulates the time at which suprachiasmatic nucleus molecular clocks enable circadian behavior
Published in Proceedings of the National Academy of Sciences - PNAS (09-02-2021)“…The suprachiasmatic nucleus (SCN), the central circadian pacemaker in mammals, is a network structure composed of multiple types of γ-aminobutyric acid…”
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The suprachiasmatic nucleus: age-related decline in biological rhythms
Published in The journal of physiological sciences (01-09-2016)“…Aging is associated with changes in sleep duration and quality, as well as increased rates of pathologic/disordered sleep. While several factors contribute to…”
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Diurnal Variation of Brain Activity in the Human Suprachiasmatic Nucleus
Published in The Journal of neuroscience (21-02-2024)“…The suprachiasmatic nucleus (SCN) is the central clock for circadian rhythms. Animal studies have revealed daily rhythms in the neuronal activity in the SCN…”
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A high-salt/high fat diet alters circadian locomotor activity and glucocorticoid synthesis in mice
Published in PloS one (21-05-2020)“…Salt is an essential nutrient; however, excessive salt intake is a prominent public health concern worldwide. Various physiological functions are associated…”
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In vivo recording of suprachiasmatic nucleus dynamics reveals a dominant role of arginine vasopressin neurons in circadian pacesetting
Published in PLoS biology (29-08-2023)“…The central circadian clock of the suprachiasmatic nucleus (SCN) is a network consisting of various types of neurons and glial cells. Individual cells have the…”
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Modeling circadian regulation of ovulation timing: age-related disruption of estrous cyclicity
Published in Scientific reports (07-10-2020)“…The circadian clocks within the hypothalamic–pituitary–gonadal axis control estrous cycles in female rodents. The suprachiasmatic nucleus (SCN), where the…”
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Acute-phase protein-like properties of endoplasmic reticulum aminopeptidase 1
Published in Journal of biochemistry (Tokyo) (01-02-2019)“…Abstract Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a multi-functional enzyme. In this study, we analysed its role in lipopolysaccharide-induced…”
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Editorial: Development of circadian clock functions, volume II
Published in Frontiers in neuroscience (16-07-2024)Get full text
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Circadian rhythm of PERIOD2::LUCIFERASE expression in the trigeminal ganglion of mice
Published in Frontiers in neuroscience (28-03-2023)“…The trigeminal nerve conveys delicate sensations such as warmth, pain, and tactile pressure in the oral and facial regions, and most trigeminal afferent cell…”
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Contribution of the exosome-associated form of secreted endoplasmic reticulum aminopeptidase 1 to exosome-mediated macrophage activation
Published in Biochimica et biophysica acta. Molecular cell research (01-06-2018)“…Macrophages secrete endoplasmic reticulum aminopeptidase 1 (ERAP1) in response to lipopolysaccharide (LPS) and interferon (IFN)-γ to enhance their phagocytic…”
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Electrophysiological Approaches to Studying the Suprachiasmatic Nucleus
Published in Methods in molecular biology (Clifton, N.J.) (2021)“…In mammals, the part of the nervous system responsible for most circadian behavior can be localized to a bilaterally paired structure in the hypothalamus known…”
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TLR-mediated secretion of endoplasmic reticulum aminopeptidase 1 from macrophages
Published in The Journal of immunology (1950) (01-05-2014)“…Macrophages play an important role in host defense under several immunological, inflammatory, and/or infectious conditions. In our previous work, we…”
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Effects of testosterone on circadian rhythmicity in old mice
Published in The journal of physiological sciences (01-09-2019)“…Serum testosterone concentration decreases with age in humans and rodents. Accordingly, old male mice show changes in locomotor activity rhythms: a lengthened…”
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Oak extracts modulate circadian rhythms of clock gene expression in vitro and wheel-running activity in mice
Published in Sleep and biological rhythms (01-04-2022)“…Introduction In mammals, the central circadian clock is located in the suprachiasmatic nucleus (SCN) of the hypothalamus, which coordinates the circadian…”
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Estrogen directly modulates circadian rhythms of PER2 expression in the uterus
Published in American journal of physiology: endocrinology and metabolism (01-11-2008)“…Fluctuations in circulating estrogen and progesterone levels associated with the estrous cycle alter circadian rhythms of physiology and behavior in female…”
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A Single Neonatal Injection of Ethinyl Estradiol Impairs Passive Avoidance Learning and Reduces Expression of Estrogen Receptor α in the Hippocampus and Cortex of Adult Female Rats
Published in PloS one (2016)“…Although perinatal exposure of female rats to estrogenic compounds produces irreversible changes in brain function, it is still unclear how the amount and…”
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Diurnal variations of triglyceride accumulation in mouse and bovine adipocyte‐derived cell lines
Published in Animal science journal (01-01-2022)“…Several studies have suggested a strong interaction between the circadian clock and lipid metabolism in mammals. The circadian clock is driven by endogenous…”
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Diurnal Variation in Trigeminal Pain Sensitivity in Mice
Published in Frontiers in neuroscience (02-08-2021)“…Management of time and circadian disruption is an extremely important factor in basic research on pain and analgesia. Although pain is known to vary throughout…”
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