Search Results - "Nakamura, Jean L."

Adverse radiation effect after stereotactic radiosurgery for brain metastases: incidence, time course, and risk factors by Sneed, Penny K, Mendez, Joe, Vemer-van den Hoek, Johanna G M, Seymour, Zachary A, Ma, Lijun, Molinaro, Annette M, Fogh, Shannon E, Nakamura, Jean L, McDermott, Michael W

“…The authors sought to determine the incidence, time course, and risk factors for overall adverse radiation effect (ARE) and symptomatic ARE after stereotactic…”
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Primary and metastatic tumors exhibit systems-level differences in dependence on mitochondrial respiratory function by Bennett, Neal K, Nakaoka, Hiroki J, Laurent, Danny, Okimoto, Ross A, Sei, Yoshitaka, Horvai, Andrew E, Bivona, Trever G, Ten Hoeve, Johanna, Graeber, Thomas G, Nakamura, Ken, Nakamura, Jean L

“…The Warburg effect, aerobic glycolysis, is a hallmark feature of cancer cells grown in culture. However, the relative roles of glycolysis and respiratory…”
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Radiotherapy-induced malignancies: review of clinical features, pathobiology, and evolving approaches for mitigating risk by Braunstein, Steve, Nakamura, Jean L

“…One of the most significant effects of radiation therapy on normal tissues is mutagenesis, which is the basis for radiation-induced malignancies…”
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A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure by Mendelsohn, Bryce A, Bennett, Neal K, Darch, Maxwell A, Yu, Katharine, Nguyen, Mai K, Pucciarelli, Daniela, Nelson, Maxine, Horlbeck, Max A, Gilbert, Luke A, Hyun, William, Kampmann, Martin, Nakamura, Jean L, Nakamura, Ken

“…Insufficient or dysregulated energy metabolism may underlie diverse inherited and degenerative diseases, cancer, and even aging itself. ATP is the central…”
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Defining the ATPome reveals cross-optimization of metabolic pathways by Bennett, Neal K., Nguyen, Mai K., Darch, Maxwell A., Nakaoka, Hiroki J., Cousineau, Derek, ten Hoeve, Johanna, Graeber, Thomas G., Schuelke, Markus, Maltepe, Emin, Kampmann, Martin, Mendelsohn, Bryce A., Nakamura, Jean L., Nakamura, Ken

“…Disrupted energy metabolism drives cell dysfunction and disease, but approaches to increase or preserve ATP are lacking. To generate a comprehensive metabolic…”
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A pooled mutational analysis identifies ionizing radiation-associated mutational signatures conserved between mouse and human malignancies by Davidson, Philip R., Sherborne, Amy L., Taylor, Barry, Nakamura, Alice O., Nakamura, Jean L.

“…Single nucleotide variants (SNVs) identified in cancer genomes can be de-convolved using non-negative matrix factorization (NMF) into discrete…”
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Mutational Analysis of Ionizing Radiation Induced Neoplasms by Sherborne, Amy L., Davidson, Philip R., Yu, Katharine, Nakamura, Alice O., Rashid, Mamunur, Nakamura, Jean L.

“…Ionizing radiation (IR) is a mutagen that promotes tumorigenesis in multiple exposure contexts. One severe consequence of IR is the development of second…”
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The epidermal growth factor receptor in malignant gliomas: pathogenesis and therapeutic implications by Nakamura, Jean L

“…Activated epidermal growth factor receptor (EGFR) has emerged as an important therapeutic target for a variety of solid tumors, particularly malignant gliomas…”
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Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors by Sherborne, Amy L, Lavergne, Vincent, Yu, Katharine, Lee, Leah, Davidson, Philip R, Mazor, Tali, Smirnoff, Ivan V, Horvai, Andrew E, Loh, Mignon, DuBois, Steven G, Goldsby, Robert E, Neglia, Joseph P, Hammond, Sue, Robison, Leslie L, Wustrack, Rosanna, Costello, Joseph F, Nakamura, Alice O, Shannon, Kevin M, Bhatia, Smita, Nakamura, Jean L

“…Second malignant neoplasms (SMNs) are severe late complications that occur in pediatric cancer survivors exposed to radiotherapy and other genotoxic…”
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Prognostic Factors for Survival in Patients Treated With Stereotactic Radiosurgery for Recurrent Brain Metastases After Prior Whole Brain Radiotherapy by Caballero, Jorge A., M.D, Sneed, Penny K., M.D, Lamborn, Kathleen R., Ph.D, Ma, Lijun, Ph.D, Denduluri, Sandeep, M.D, Nakamura, Jean L., M.D, Barani, Igor J., M.D, McDermott, Michael W., M.D

“…Purpose To evaluate prognostic factors for survival after stereotactic radiosurgery (SRS) for new, progressive, or recurrent brain metastases (BM) after prior…”
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Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice by Mroue, Rana, Huang, Brian, Braunstein, Steve, Firestone, Ari J, Nakamura, Jean L

“…Imprinted genes are expressed from only one parental allele and heterozygous loss involving the expressed allele is sufficient to produce complete loss of…”
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Response of primary glioblastoma cells to therapy is patient specific and independent of cancer stem cell phenotype by Fouse, Shaun D, Nakamura, Jean L, James, C David, Chang, Susan, Costello, Joseph F

“…Glioblastoma multiforme (GBM) contains a population of cells that exhibit stem cell phenotypes. These cancer stem cells (CSCs) may be a source of therapeutic…”
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S6K1 plays a key role in glial transformation by Nakamura, Jean L, Garcia, Edna, Pieper, Russell O

“…The mammalian target of rapamycin (mTOR) is a nutrient and ATP sensor suggested to play an important role in tumorigenesis, particularly in the setting of PTEN…”
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Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms by Choi, Grace, Huang, Brian, Pinarbasi, Emile, Braunstein, Steve E, Horvai, Andrew E, Kogan, Scott, Bhatia, Smita, Faddegon, Bruce, Nakamura, Jean L

“…Second malignant neoplasms (SMN) are therapy-induced malignancies and a growing problem in cancer survivors, particularly survivors of childhood cancers. The…”
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Correction: Monoallelic Loss of the Imprinted Gene Grb10 Promotes Tumor Formation in Irradiated Nf1+/- Mice by Mroue, Rana, Huang, Brian, Braunstein, Steve, Firestone, Ari J, Nakamura, Jean L

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Gamma Knife radiosurgery for brainstem metastases: the UCSF experience by Kased, Norbert, Huang, Kim, Nakamura, Jean L., Sahgal, Arjun, Larson, David A., McDermott, Michael W., Sneed, Penny K.

“…Purpose : To assess clinical and imaging outcomes in patients treated with Gamma Knife stereotactic radiosurgery (SRS) for brainstem metastases. Materials and…”
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Gamma Knife Radiosurgery for Brain Metastases From Primary Breast Cancer by Kased, Norbert, M.D, Binder, Devin K., M.D., Ph.D, McDermott, Michael W., M.D, Nakamura, Jean L., M.D, Huang, Kim, M.D, Berger, Mitchel S., M.D, Wara, William M., M.D, Sneed, Penny K., M.D

“…Purpose The relative roles of stereotactic radiosurgery (SRS) vs. whole brain radiotherapy (WBRT) in the treatment of patients with brain metastases from…”
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Considerations for carcinogenesis countermeasure development using mouse models by Nakamura, Jean L.

“…Activities in space will expose humans to profoundly new environments, challenging human performance and will require innovative supportive technologies. Among…”
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Dose conformity of gamma knife radiosurgery and risk factors for complications by Nakamura, J L, Verhey, L J, Smith, V, Petti, P L, Lamborn, K R, Larson, D A, Wara, W M, McDermott, M W, Sneed, P K

“…To quantitatively evaluate dose conformity achieved using Gamma Knife radiosurgery, compare results with those reported in the literature, and evaluate risk…”
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Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism by Gottschalk, Alexander R, Doan, Albert, Nakamura, Jean L, Stokoe, David, Haas-Kogan, Daphne A

“…To identify whether inhibition of phosphatidylinositol-3-kinase (PI3K) causes increased radiosensitivity through inhibition of protein kinase B (PKB),…”
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