Search Results - "Nakamoto, Hitoshi"

The therapeutic target Hsp90 and cancer hallmarks by Miyata, Yoshihiko, Nakamoto, Hitoshi, Neckers, Len

“…Hsp90 is a major molecular chaperone that is expressed abundantly and plays a pivotal role in assisting correct folding and functionality of its client…”
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pH-regulated chaperone function of cyanobacterial Hsp90 and Hsp70: implications for light/dark regulation by Akter, Tahmina, Nakamoto, Hitoshi

“…Abstract We have shown that cyanobacterial chaperonins have pH-dependent anti-aggregation activity. The pH in cyanobacterial cytosol increases by one pH unit…”
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pH-mediated control of anti-aggregation activities of cyanobacterial and E. coli chaperonin GroELs by Akter, Tahmina, Nakamoto, Hitoshi

“…In contrast to Escherichia coli, cyanobacteria have multiple GroELs, the bacterial homologues of chaperonin/Hsp60. We have shown that cyanobacterial GroELs are…”
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Non‐housekeeping, non‐essential GroEL (chaperonin) has acquired novel structure and function beneficial under stress in cyanobacteria by Nakamoto, Hitoshi, Kojima, Kouji

“…GroELs which are prokaryotic members of the chaperonin (Cpn)/Hsp60 family are molecular chaperones of which Escherichia coli GroEL is a model for subsequent…”
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A cyclic lipopeptide surfactin is a species-selective Hsp90 inhibitor that suppresses cyanobacterial growth by Nakamoto, Hitoshi, Yokoyama, Yuhei, Suzuki, Takahiro, Miyamoto, Yuri, Fujishiro, Takashi, Morikawa, Masaaki, Miyata, Yoshihiko

“…Abstract Heat shock protein 90 (Hsp90) is essential for eukaryotic cells, whereas bacterial homologs play a role under stresses and in pathogenesis…”
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Catalysis of disulfide bond formation and isomerization in the Escherichia coli periplasm by Nakamoto, Hitoshi, Bardwell, James C.A.

“…Disulfide bond formation is a catalyzed process in vivo. In prokaryotes, the oxidation of cysteine pairs is achieved by the transfer of disulfides from the…”
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Evaluation of Open Reduction and Internal Fixation of Mandibular Condyle Fracture by Intraoperative Cone-Beam Computed Tomography in a Hybrid Operating Room by Sukegawa, Shintaro, Masui, Masanori, Kanno, Takahiro, Miki, Masayuki, Nakamoto, Hitoshi, Furuki, Yoshihiko

“…Condylar fractures are the most common fractures of the mandible, and treatment of mandibular condylar fractures by maxillofacial surgeons is a very important…”
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HtpG, the prokaryotic homologue of Hsp90, stabilizes a phycobilisome protein in the cyanobacterium Synechococcus elongatus PCC 7942 by Sato, Takeshi, Minagawa, Shun, Kojima, Erika, Okamoto, Naoki, Nakamoto, Hitoshi

“…HtpG, a homologue of HSP90, is essential for thermotolerance in cyanobacteria. It is not known how it plays this important role. We obtained evidence that HtpG…”
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Regulation of the groESL1 transcription by the HrcA repressor and a novel transcription factor Orf7.5 in the cyanobacterium Synechococcus elongatus PCC7942 by Saito, Masakazu, Watanabe, Satoru, Nimura-Matsune, Kaori, Yoshikawa, Hirofumi, Nakamoto, Hitoshi

“…The CIRCE/HrcA system is highly conserved in cyanobacterial genomes. We have shown that heat-shock induction of the groESL1 operon in the cyanobacterium…”
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Stimulation of the ATPase activity of Hsp90 by zerumbone modification of its cysteine residues destabilizes its clients and causes cytotoxicity by Nakamoto, Hitoshi, Amaya, Yosuke, Komatsu, Taiwa, Suzuki, Takehiro, Dohmae, Naoshi, Nakamura, Yusuke, Jantan, Ibrahim, Miyata, Yoshihiko

“…Hsp90 is an ATP-dependent molecular chaperone that assists folding and conformational maturation/maintenance of many proteins. It is a potential cancer drug…”
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Cyclic lipopeptide antibiotics bind to the N-terminal domain of the prokaryotic Hsp90 to inhibit the chaperone activity by Minagawa, Shun, Kondoh, Yasumitsu, Sueoka, Keigo, Osada, Hiroyuki, Nakamoto, Hitoshi

“…Chemical arrays were employed to screen ligands for HtpG, the prokaryotic homologue of Hsp (heat-shock protein) 90. We found that colistins and the closely…”
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Light-driven Hydrogen Production by a Hybrid Complex of a [NiFe]-Hydrogenase and the Cyanobacterial Photosystem I by Ihara, Masaki, Nishihara, Hirofumi, Yoon, Ki-Seok, Lenz, Oliver, Friedrich, Bärbel, Nakamoto, Hitoshi, Kojima, Kouji, Honma, Daisuke, Kamachi, Toshiaki, Okura, Ichiro

“…In order to generate renewable and clean fuels, increasing efforts are focused on the exploitation of photosynthetic microorganisms for the production of…”
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small heat-shock protein confers stress tolerance and stabilizes thylakoid membrane proteins in cyanobacteria under oxidative stress by Sakthivel, Kollimalai, Watanabe, Tatsuro, Nakamoto, Hitoshi

“…Small heat-shock proteins are molecular chaperones that bind and prevent aggregation of nonnative proteins. They also associate with membranes. In this study,…”
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Goniothalamin enhances the ATPase activity of the molecular chaperone Hsp90 but inhibits its chaperone activity by Yokoyama, Yuhei, Ohtaki, Aguru, Jantan, Ibrahim, Yohda, Masafumi, Nakamoto, Hitoshi

“…Hsp90 is an ATP-dependent molecular chaperone that is involved in important cellular pathways such as signal transduction pathways. It is a potential cancer…”
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Intact Carboxysomes in a Cyanobacterial Cell Visualized by Hilbert Differential Contrast Transmission Electron Microscopy by Kaneko, Yasuko, Danev, Radostin, Nagayama, Kuniaki, Nakamoto, Hitoshi

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A novel light- and heat-responsive regulation of the groE transcription in the absence of HrcA or CIRCE in cyanobacteria by Kojima, Kouji, Nakamoto, Hitoshi

“…The inactivation of the hrcA gene resulted in de-repression of the two CIRCE-containing groE genes in a cyanobacterium Synechocystis sp. strain PCC6803,…”
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Comparative Biochemical Characterization of Two GroEL Homologs from the Cyanobacterium Synechococcus elongatus PCC 7942 by HUQ, Saaimatul, SUEOKA, Keigo, NARUMI, Shoichi, ARISAKA, Fumio, NAKAMOTO, Hitoshi

“…Unlike Escherichia coli, cyanobacteria generally contain two GroEL homologs. The chaperone function of cyanobacterial GroELs was examined in vitro for the…”
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Targeted inactivation of the hrcA repressor gene in cyanobacteria by Nakamoto, Hitoshi, Suzuki, Michiru, Kojima, Kouji

“…To determine if the CIRCE/HrcA system operates in cyanobacteria, we have inactivated the hrcA repressor gene in Synechocystis sp. PCC 6803 by gene targeting…”
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HtpG is essential for the thermal stress management in cyanobacteria by Tanaka, Naoki, Nakamoto, Hitoshi

“…The heat shock protein (Hsp) HtpG is a member of the Hsp90 protein family. We cloned a single-copy gene encoding a homologue of HtpG from the unicellular…”
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Constitutive expression of a small heat-shock protein confers cellular thermotolerance and thermal protection to the photosynthetic apparatus in cyanobacteria by Nakamoto, Hitoshi, Suzuki, Nobuaki, Roy, Sanjit Kumer

“…The role of a small heat-shock protein (Hsp) in the acquisition of thermotolerance in cyanobacteria was investigated. Synechococcus sp. PCC 7942 was…”
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