High-fat diets provoke phosphorus absorption from the small intestine in rats

•A high-fat diet increases the apparent absorption rate of phosphorus.•A high-fat diet increases type-IIb sodium-phosphate cotransporter and type-III sodium-phosphate cotransporter expression in the duodenum.•Dietary fat might be an important factor in the control of serum phosphorus levels. The rat...

Full description

Saved in:

Bibliographic Details
Published in:	Nutrition (Burbank, Los Angeles County, Calif.) Vol. 72; p. 110694
Main Authors:	Kawamoto, Keisuke, Sakuma, Masae, Tanaka, Sarasa, Masuda, Masashi, Nakao-Muraoka, Mari, Niida, Yuki, Nakamatsu, Yurino, Ito, Mikiko, Taketani, Yutaka, Arai, Hidekazu
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-04-2020 Elsevier Limited
Subjects:	Absorption Animals Calcium Calcium (dietary) Calcium - metabolism Calcium absorption Carbohydrates Diet Diet, High-Fat Dietary fat Dietary Fats - pharmacology Duodenum Duodenum - metabolism Fat metabolism Feces Feces - chemistry Food Gene expression High fat diet Intestinal Absorption - drug effects Intestine Intestine, Small - metabolism Jejunum Laboratory animals Male Metabolism Phosphate Phosphates Phosphorus Phosphorus - metabolism Pit1 protein Polymerase chain reaction Ratios Rats Rats, Sprague-Dawley Saturated fat Serum phosphorus levels Small intestine Sodium Sodium-Phosphate Cotransporter Proteins, Type IIb - metabolism Sodium-Phosphate Cotransporter Proteins, Type III - metabolism Urine United States > US Japan Dietary fat Saturated fat Calcium Serum phosphorus levels duodenum
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	•A high-fat diet increases the apparent absorption rate of phosphorus.•A high-fat diet increases type-IIb sodium-phosphate cotransporter and type-III sodium-phosphate cotransporter expression in the duodenum.•Dietary fat might be an important factor in the control of serum phosphorus levels. The ratio of dietary carbohydrate to fat may affect phosphorus metabolism because both calcium and phosphorus are regulated by similar metabolic mechanisms, and a high-fat diet (HFD) induces deleterious effects on the absorption of dietary calcium. We hypothesized that an HFD induces an increase in phosphorus absorption. The aim of this study was to evaluate the effects of differences in the quantity and quality of dietary fat on phosphorus metabolism over the short- and long-term. Eighteen 8-wk-old Sprague–Dawley male rats were fed an isocaloric diet containing varied ratios of carbohydrates to fat energy and sources of fat (control diet, HFD, and high- saturated fat diet [HF-SFA]). At 3 d and 7 wk after the allocation and initiation of the test diets, feces and urine were collected and used for phosphorus and calcium measurement. The fecal phosphorous concentration (F-Pi) was lower in the HF-SFA group than in the other two groups; however, the urine phosphorus concentration (U-Pi) was significantly higher in the HF-SFA group than the other two groups when the rats were fed over the short- (P < 0.01) and long -term (P < 0.01 versus control, P < 0.05 versus HFD group). There were no significant differences in type-IIa sodium-phosphate cotransporter (NaPi-2 a) and type-IIc sodium-phosphate cotransporter (NaPi-2 c) mRNA expression, which are renal phosphate transport-related genes; however, the expression of type-IIb sodium-phosphate cotransporter (NaPi-2 b) and type-III sodium-phosphate cotransporter (Pit-1) mRNA in the duodenum was higher in the HFD and HF-SFA groups than in the control group (P < 0.05), although there were no significant differences in these in the jejunum. The present results indicated that an HFD, particularly HF-SFA, increases intestinal phosphate absorption compared with control.
ISSN:	0899-9007 1873-1244
DOI:	10.1016/j.nut.2019.110694