Search Results - "Nakajima, Toshiharu"

Inhibition Effect of Eucommia ulmoides Leaf Extract on Interleukin 8 Production by A549 Cells by Kaneko, Masahiro, Iizuka, Toru, Nakajima, Toshiharu

“…Asthma is characterized by chronic inflammation of the airway mucosa. As Eucommia ulmoides Oliv. leaf extract (ELE) has been known to have anti-inflammatory…”
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Hierarchical Organization of Photoresponsive Hydrogen-Bonded Rosettes by Yagai, Shiki, Nakajima, Toshiharu, Kishikawa, Keiki, Kohmoto, Shigeo, Karatsu, Takashi, Kitamura, Akihide

“…Hydrogen-bonded disk-shaped aggregates (rosettes) composed of azobenzene-appended melamine and barbiturate or cyanurate are investigated in view of their…”
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Toll-like receptor 3 ligand specifically induced bronchial epithelial cell death in caspase dependent manner and functionally upregulated Fas expression by Koizumi, Yuta, Nagase, Hiroyuki, Nakajima, Toshiharu, Kawamura, Masafumi, Ohta, Ken

“…Viral infections are the most common cause of asthma exacerbation. Virally infected epithelial cells undergo apoptosis. Although in healthy conditions,…”
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Apoptosis Occurs during Early Development of the Bursa of Fabricius in Chicken Embryos by Makino, Kota, Omachi, Runa, Suzuki, Hiroka, Tomobe, Koji, Kawashima, Tsuyoshi, Nakajima, Toshiharu, Kawashima-Ohya, Yoshie

“…The bursa of Fabricius (BF) is a unique primary lymphoid organ, and among vertebrates is unique to birds. Despite its importance to the immune systems of…”
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Cimetidine Enhances Antigen-Specific IgE and Th2 Cytokine Production by Arae, Ken, Oboki, Keisuke, Ohno, Tatsukuni, Hirata, Masako, Nakae, Susumu, Taguchi, Haruhiko, Saito, Hirohisa, Nakajima, Toshiharu

“…Treatment with anti-ulcer drugs has been shown to enhance IgE production against food antigens. However, little is known about the immunological effects of…”
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Inducible Expression of a Th2-Type CC Chemokine Thymus- and Activation-Regulated Chemokine by Human Bronchial Epithelial Cells by Sekiya, Takashi, Miyamasu, Misato, Imanishi, Masako, Yamada, Hirokazu, Nakajima, Toshiharu, Yamaguchi, Masao, Fujisawa, Takao, Pawankar, Ruby, Sano, Yasuyuki, Ohta, Ken, Ishii, Akira, Morita, Yutaka, Yamamoto, Kazuhiko, Matsushima, Kouji, Yoshie, Osamu, Hirai, Koichi

“…CCR4 is now known to be selectively expressed in Th2 cells. Since the bronchial epithelium is recognized as an important source of mediators fundamental to the…”
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A Target Selection of Somatic Hypermutations Is Regulated Similarly between T and B Cells upon Activation-Induced Cytidine Deaminase Expression by Kotani, Ai, Okazaki, Il-mi, Muramatsu, Masamichi, Kinoshita, Kazuo, Begum, Nasim A., Nakajima, Toshiharu, Saito, Hirohisa, Honjo, Tasuku

“…Activation-induced cytidine deaminase (AID) is essential for somatic hypermutations (SHM) and class switch recombination. Overexpression of AID in non-B cells…”
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Molecular Cloning of a Novel Human CC Chemokine (Eotaxin-3) That Is a Functional Ligand of CC Chemokine Receptor 3 by Kitaura, Motoji, Suzuki, Noriko, Imai, Toshio, Takagi, Shin, Suzuki, Ryuji, Nakajima, Toshiharu, Hirai, Koichi, Nomiyama, Hisayuki, Yoshie, Osamu

“…Previously, we mapped the novel CC chemokine myeloid progenitor inhibitory factor 2 (MPIF-2)/eotaxin-2 to chromosome 7q11.23 (Nomiyama, H., Osborne, L. R.,…”
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Th1- and Th2-Type Cytokines Regulate the Expression and Production of Eotaxin and RANTES by Human Lung Fibroblasts by Teran, Luis M, Mochizuki, Mitsuru, Bartels, Joachim, Valencia, Elba L, Nakajima, Toshiharu, Hirai, Koichi, Schroder, Jens-M

“…Eosinophils (Eos) and fibroblasts are known to play a major role in the pathogenesis of bronchial asthma and fibrotic lung disease. Therefore, we investigated…”
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Corneal and Conjunctival Fibroblasts Are Major Sources of Eosinophil-Recruiting Chemokines by Fukagawa, Kazumi, Okada, Naoko, Fujishima, Hiroshi, Nakajima, Toshiharu, Takano, Yoji, Tanaka, Mari, Dogru, Murat, Satake, Yoshiyuki, Tsubota, Kazuo, Saito, Hirohisa

“…Differential expression of chemokine genes were investigated in various types of ocular surface cells. Primary cultures of human corneal epithelial cells (n =…”
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FUNCTIONAL CHARACTERIZATION OF THREE NATURALLY OCCURRING SINGLE NUCLEOTIDE POLYMORPHISMS IN THE CES2 GENE ENCODING CARBOXYLESTERASE 2 (HCE-2) by KUBO, Takashi, KIM, Su-Ryang, OHTSU, Atsushi, YOSHIDA, Teruhiko, SAIJO, Nagahiro, OHNO, Yasuo, OZAWA, Shogo, SAWADA, Jun-Ichi, SAI, Kimie, SAITO, Yoshiro, NAKAJIMA, Toshiharu, MATSUMOTO, Kenji, SAITO, Hirohisa, SHIRAO, Kuniaki, YAMAMOTO, Noboru, MINAMI, Hironobu

“…Twelve single nucleotide polymorphisms (SNPs) in the human CES2 gene, which encodes a carboxylesterase, hCE-2 [human carboxylesterase 2 (EC 3.1.1.1)], have…”
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The Implications of the Upregulation of ICAM-1/VCAM-1 Expression of Corneal Fibroblasts on the Pathogenesis of Allergic Keratopathy by Okada, Naoko, Fukagawa, Kazumi, Takano, Yoji, Dogru, Murat, Tsubota, Kazuo, Fujishima, Hiroshi, Matsumoto, Kenji, Nakajima, Toshiharu, Saito, Hirohisa

“…The present study investigated the expression of ICAM-1 and VCAM-1 on fibroblasts with interleukin (IL)-4 and/or tumor necrosis factor (TNF)-alpha stimulation…”
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Identification of granulocyte subtype–selective receptors and ion channels by using a high-density oligonucleotide probe array by Nakajima, Toshiharu, Iikura, Motoyasu, Okayama, Yoshimichi, Matsumoto, Kenji, Uchiyama, Chitose, Shirakawa, Taro, Yang, Xing, Adra, Chaker N., Hirai, Koichi, Saito, Hirohisa

“…During inflammation, neutrophils, basophils, and eosinophils release cell type–specific mediators and proteases through signaling molecules, such as G…”
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Gene expression screening of human mast cells and eosinophils using high-density oligonucleotide probe arrays: abundant expression of major basic protein in mast cells by Nakajima, Toshiharu, Matsumoto, Kenji, Suto, Hajime, Tanaka, Kazuko, Ebisawa, Motohiro, Tomita, Hisashi, Yuki, Keisuke, Katsunuma, Toshio, Akasawa, Akira, Hashida, Ryoichi, Sugita, Yuji, Ogawa, Hideoki, Ra, Chisei, Saito, Hirohisa

“…Mast cells (MCs) and eosinophils are thought to play important roles in evoking allergic inflammation. Cell-type–specific gene expression was screened among 12…”
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Characterization of Mast Cell-Committed Progenitors Present in Human Umbilical Cord Blood by Kempuraj, Duraisamy, Saito, Hirohisa, Kaneko, Azusa, Fukagawa, Kazumi, Nakayama, Masaharu, Toru, Hano, Tomikawa, Morimitsu, Tachimoto, Hiroshi, Ebisawa, Motohiro, Akasawa, Akira, Miyagi, Toko, Kimura, Hiromitsu, Nakajima, Toshiharu, Tsuji, Kohichiro, Nakahata, Tatsutoshi

“…Human mast cells are derived from CD34+ hematopoietic cells present in cord blood, bone marrow, and peripheral blood. However, little is known about the…”
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Cimetidine Enhances Antigen-Specific IgE and Th2 Cytokine Production by Ken Arae, Keisuke Oboki, Tatsukuni Ohno, Masako Hirata, Susumu Nakae, Haruhiko Taguchi, Hirohisa Saito, Toshiharu Nakajima

“…[ABSTRACT] Background: Treatment with anti-ulcer drugs has been shown to enhance IgE production against food antigens. However, little is known about the…”
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Novel Genetic Polymorphisms in the NR3C1 (Glucocorticoid receptor) Gene in a Japanese Population by Koyano, Satoru, Saito, Yoshiro, Sai, Kimie, Kurose, Kouichi, Ozawa, Shogo, Nakajima, Toshiharu, Matsumoto, Kenji, Saito, Hirohisa, Shirao, Kuniaki, Yoshida, Teruhiko, Minami, Hironobu, Ohtsu, Atsushi, Saijo, Nagahiro, Sawada, Jun-ichi

“…Glucocorticoid receptor, encoded by NR3C1, is a transcriptional regulator of many drug metabolizing enzymes and anti-inflammatory molecules. In order to…”
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FUNCTIONAL CHARACTERIZATION OF FOUR NATURALLY OCCURRING VARIANTS OF HUMAN PREGNANE X RECEPTOR (PXR): ONE VARIANT CAUSES DRAMATIC LOSS OF BOTH DNA BINDING ACTIVITY AND THE TRANSACTIVATION OF THE CYP3A4 PROMOTER/ENHANCER REGION by KOYANO, Satoru, KUROSE, Kouichi, MATSUMOTO, Kenji, AKASAWA, Akira, SAITO, Hirohisa, SAWADA, Jun-Ichi, SAITO, Yoshiro, OZAWA, Shogo, HASEGAWA, Ryuichi, KOMAMURA, Kazuo, UENO, Kazuyuki, KAMAKURA, Shiro, KITAKAZE, Masafumi, NAKAJIMA, Toshiharu

“…Metabolism of administered drugs is determined by expression and activity of many drug-metabolizing enzymes, such as the cytochrome P450 (P450s) family…”
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Inhibitory effect of baicalein, a flavonoid in Scutellaria Root, on eotaxin production by human dermal fibroblasts by Nakajima, T, Imanishi, M, Yamamoto, K, Cyong, J C, Hirai, K

“…Eotaxin is an eosinophil-specific chemokine associated with the recruitment of eosinophils to sites of allergic inflammation. "Saiboku-to" (Formula magnoliae…”
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Human mast cell transcriptome project by Saito, H, Nakajima, T, Matsumoto, K

“…After draft reading of the human genome sequence, systemic analysis of the transcriptome (the whole transcripts present in a cell) is progressing especially in…”
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