Search Results - "Nakai, D."

Inhibition of human organic anion transporter 3 mediated pravastatin transport by gemfibrozil and the metabolites in humans by Nakagomi-Hagihara, R., Nakai, D., Tokui, T.

“…Coadministration of gemfibrozil (600 mg, b.i.d., 3 days) with pravastatin (40 mg/day) decreased the renal clearance of pravastatin by approximately 40% in…”
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OC019—Intrapulmonary Pharmacokinetics (Pk) And The Intracellular Disposition To Support The Long-Lasting Efficacy After An Inhaled Administration Of Its Prodrug Laninamivir Octanoate (Lo) by Toyama, K, Furuie, H, Koyama, K, Nakai, D, Ishizuka, H

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Gemfibrozil and its glucuronide inhibit the hepatic uptake of pravastatin mediated by OATP1B1 by Nakagomi-Hagihara, R., Nakai, D., Tokui, T., Abe, T., Ikeda, T.

“…When pravastatin (40 mg/day) was co-administered with gemfibrozil (600 mg, b.i.d., 3 days) to man, the AUC of pravastatin increased approximately 2-fold. We…”
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Molecular characterization and functional regulation of a novel rat liver-specific organic anion transporter rlst-1 by Kakyo, Masayuki, Unno, Michiaki, Tokui, Taro, Nakagomi, Rie, Nishio, Toshiyuki, Iwasashi, Hajime, Nakai, Daisuke, Seki, Makoto, Suzuki, Masanori, Naitoh, Takeshi, Matsuno, Seiki, Yawo, Hiromu, Abe, Takaaki

“…Background & Aims: Recently, we isolated a new complementary DNA (cDNA) encoding human liver-specific organic anion transporter (LST-1), representing the…”
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Cellular uptake mechanism for oligonucleotides: involvement of endocytosis in the uptake of phosphodiester oligonucleotides by a human colorectal adenocarcinoma cell line, HCT-15 by Nakai, D, Seita, T, Terasaki, T, Iwasa, S, Shoji, Y, Mizushima, Y, Sugiyama, Y

“…We used a 20-mer antisense oligonucleotide against human MDR1 mRNA to study the mechanism of uptake of oligonucleotides by a human colorectal adenocarcinoma…”
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Design and synthesis of oatp subtype-specific antisense oligonucleotides having 2′-O,4′-C-ethylene-bridged nucleic acids (ENA™) by Takagi, Miho, Morita, Koji, Nakai, Daisuke, Nakagomi, Rie, Tokui, Taro, Koizumi, Makoto

“…To select antisense oligonucleotides (AONs) that specifically target the genes of rat organic anion transporting polypeptide (oatp) subtypes, in vitro…”
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T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice by Terasaka, Naoki, Hiroshima, Ayano, Koieyama, Tadashi, Ubukata, Naoko, Morikawa, Yuka, Nakai, Daisuke, Inaba, Toshimori

“…Liver X receptors (LXRα and LXRβ) are nuclear receptors, which are important regulators of cholesterol and lipid metabolism. LXRs control genes involved in…”
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Evaluation of the efficiency of targeting of antitumor drugs: simulation analysis based on pharmacokinetic/pharmacodynamic considerations by Nakai, D, Fuse, E, Suzuki, H, Inaba, M, Sugiyama, Y

“…Antitumor drugs can be classified into two groups; cell cycle phase nonspecific (type I) and specific (type II) drugs. The cytotoxic activity of type I drugs…”
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Identification of an autonomous transactivation domain in helix H3 of the vitamin D receptor by Kraichely, Dennis M., Nakai, Yuichiro D., MacDonald, Paul N.

“…The vitamin D receptor (VDR) contains an α‐helical, ligand‐inducible activation function (AF‐2) at the COOH‐terminus of the ligand‐binding domain (LBD). In…”
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Structure-based targeting of bioactive proteins into cypovirus polyhedra and application to immobilized cytokines for mammalian cell culture by Ijiri, Hiroshi, Coulibaly, Fasséli, Nishimura, Gento, Nakai, Daisuke, Chiu, Elaine, Takenaka, Chiemi, Ikeda, Keiko, Nakazawa, Hiroshi, Hamada, Norio, Kotani, Eiji, Metcalf, Peter, Kawamata, Shin, Mori, Hajime

“…Abstract Certain insect viruses produce stable infectious micro-crystals called polyhedra which function to protect the virus after the death of infected…”
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OATP1B1, OATP1B3, AND MRP2 ARE INVOLVED IN HEPATOBILIARY TRANSPORT OF OLMESARTAN, A NOVEL ANGIOTENSIN II BLOCKER by NAKAGOMI-HAGIHARA, Rie, NAKAI, Daisuke, KAWAI, Kenji, YOSHIGAE, Yasushi, TOKUI, Taro, ABE, Takaaki, IKEDA, Toshihiko

“…Hepatic uptake and biliary excretion of olmesartan, a new angiotensin II blocker, were investigated in vitro using human hepatocytes, cells expressing uptake…”
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Identification of a Novel Gene Family Encoding Human Liver-specific Organic Anion Transporter LST-1 by Abe, T, Kakyo, M, Tokui, T, Nakagomi, R, Nishio, T, Nakai, D, Nomura, H, Unno, M, Suzuki, M, Naitoh, T, Matsuno, S, Yawo, H

“…We have isolated a novel liver-specific organic anion transporter, LST-1, that is expressed exclusively in the human, rat, and mouse liver. LST-1 is a new gene…”
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Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes by Nakai, D, Nakagomi, R, Furuta, Y, Tokui, T, Abe, T, Ikeda, T, Nishimura, K

“…Involvement of LST-1 (a human liver-specific transporter, also called OATP2) as the major transporter in the uptake of pravastatin, a…”
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Unilateral Urological Double Cancer after Kidney Transplantation: 2408 by Moriyama, M. T., Nakai, D., Morita, N., Ishii, T., Tachibana, H., Chikazawa, I., Suga, K., Miyazawa, K., Tanaka, T., Suzuki, K.

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Evaluation of the protein binding ratio of drugs by a micro-scale ultracentrifugation method by Nakai, Daisuke, Kumamoto, Kazuyo, Sakikawa, Chisa, Kosaka, Toshiyuki, Tokui, Taro

“…Ultracentrifugation methods have been widely used for the determination of the free fraction of compounds in plasma, especially for lipophilic compounds. To…”
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Electrohydraulic lithotripsy through a fistula of EUS-guided hepaticogastrostomy: a new approach for right intrahepatic stones by Sato, Tatsuya, MD, Nakai, Yousuke, MD, PhD, Kogure, Hirofumi, MD, PhD, Isayama, Hiroyuki, MD, PhD, Koike, Kazuhiko, MD, PhD

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Mouse Homologue of coq7/clk-1, Longevity Gene in Caenorhabditis elegans, Is Essential for Coenzyme Q Synthesis, Maintenance of Mitochondrial Integrity, and Neurogenesis by Nakai, Daisuke, Yuasa, Shigeki, Takahashi, Mayumi, Shimizu, Takahiko, Asaumi, Sunao, Isono, Kyoichi, Takao, Toshifumi, Suzuki, Yo-ichi, Kuroyanagi, Hidehito, Hirokawa, Katsuiku, Koseki, Haruhiko, Shirsawa, Takuji

“…coq7/clk-1 was isolated from a long-lived mutant of Caenorhabditis elegans, which showed sluggish behavior and an extended life span. Mouse coq7 is homologous…”
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Un-cooled operation (10°C to 85°C) of a 10.7-Gbit/s 1.55-μm electro- absorption modulator integrated DFB laser for 40-km transmission by Sasada, N, Naoe, K, Sakuma, Y, Washino, R, Nakai, D, Motoda, K, Makino, S, Shinoda, K, Shiota, T, Kitatani, T, Fukamachi, T, Aoki, M

“…A modulated output-power more than +3.7 dBm, a dynamic extinction-ratio over 9.3 dB, and a power- penalty below 1.8 dB were achieved for 10.7-Gbit/s, 40-km…”
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Electrohydraulic lithotripsy under double-balloon endoscope–assisted direct cholangioscopy for treatment of choledocholithiasis in a patient with Roux-en-Y gastrectomy by Sato, Tatsuya, MD, Kogure, Hirofumi, MD, PhD, Nakai, Yousuke, MD, PhD, Isayama, Hiroyuki, MD, PhD, Koike, Kazuhiko, MD, PhD

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Pravastatin, an HMG-CoA reductase inhibitor, is transported by rat organic anion transporting polypeptide, oatp2 by TOKUI, T, NAKAI, D, NAKAGOMI, R, YAWO, H, ABE, T, SUGIYAMA, Y

“…We previously demonstrated the HMG-CoA reductase inhibitor, pravastatin, is actively taken up into isolated rat hepatocytes through multispecific organic anion…”
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