Search Results - "Nakahara, Kunio"

Effect of FR167653, a cytokine suppressive agent, on endotoxin-induced disseminated intravascular coagulation by Yamamoto, Nobuchika, Sakai, Fumihiko, Yamazaki, Harumi, Nakahara, Kunio, Okuhara, Masakuni

“…R167653 (1-[7-(4-fluorophenyl)-1,2,3,4-tetrahydro-8-(4-pyridyl)pyrazolo[5,1- c][1,2,4]triazin-2-yl]-2-phenylethanedione sulfate monohydrate) is a low molecular…”
Get full text

The identification of an orally active, nonpeptide bradykinin B2 receptor antagonist, FR173657 by Asano, Masayuki, Inamura, Noriaki, Hatori, Chie, Sawai, Hiroe, Fujiwara, Tatsujiro, Katayama, Akira, Kayakiri, Hiroshi, Satoh, Shigeki, Abe, Yoshito, Inoue, Takayuki, Sawada, Yuki, Nakahara, Kunio, Oku, Teruo, Okuhara, Masakuni

“…1 An orally active, nonpeptide bradykinin (BK) B2 receptor antagonist, FR173657 (E)‐3‐(6‐acetamido‐3‐pyridyl)‐N‐[N‐[2‐4‐dichloro‐3‐[(2‐methyl‐8‐quinolinyl)…”
Get full text

Nonpeptide mimic of bradykinin with long-acting properties at the bradykinin B2 receptor by Aramori, I, Zenkoh, J, Morikawa, N, Asano, M, Hatori, C, Sawai, H, Kayakiri, H, Satoh, S, Inoue, T, Abe, Y, Sawada, Y, Mizutani, T, Inamura, N, Nakahara, K, Kojo, H, Oku, T, Notsu, Y

“…Kinins, members of a family of peptides released from kininogens by the action of kallikreins, exhibit a variety of biological activities including…”
Get more information

Effects of a nonpeptide bradykinin B2 receptor antagonist, FR167344, on different in vivo animal models of inflammation by Asano, Masayuki, Hatori, Chie, Inamura, Noriaki, Sawai, Hiroe, Hirosumi, Jiro, Fujiwara, Tatsujiro, Nakahara, Kunio

“…1 The effects of a novel, potent and orally active nonpeptide bradykinin B2 receptor antagonist, FR167344 (N ‐[N ‐[3 ‐[(3 ‐ bromo‐ 2…”
Get full text

Pharmacological characterization of a nonpeptide bradykinin B2 receptor antagonist, FR165649, and agonist, FR190997 by Asano, Masayuki, Hatori, Chie, Sawai, Hiroe, Johki, Shigeru, Inamura, Noriaki, Kayakiri, Hiroshi, Satoh, Shigeki, Abe, Yoshito, Inoue, Takayuki, Sawada, Yuki, Mizutani, Tsuyoshi, Oku, Teruo, Nakahara, Kunio

“…The nonpeptide bradykinin (BK) B2 receptor antagonist, FR165649 (8‐[2,6‐dichloro‐3‐[N‐[(E)‐4‐(N‐ methylcarbamoyl)cinnamidoacetyl] ‐N‐methylamino] benzyloxy] ‐2…”
Get full text

The identification of an orally active, nonpeptide bradykinin B 2 receptor antagonist, FR173657 by Asano, Masayuki, Inamura, Noriaki, Hatori, Chie, Sawai, Hiroe, Fujiwara, Tatsujiro, Katayama, Akira, Kayakiri, Hiroshi, Satoh, Shigeki, Abe, Yoshito, Inoue, Takayuki, Sawada, Yuki, Nakahara, Kunio, Oku, Teruo, Okuhara, Masakuni

“…An orally active, nonpeptide bradykinin (BK) B 2 receptor antagonist, FR173657 (E)‐3‐(6‐acetamido‐3‐pyridyl)‐N‐[N‐[2‐4‐dichloro‐3‐[(2‐methyl‐8‐quinolinyl)…”
Get full text

Pharmacological characterization of a novel, orally active, nonpeptide bradykinin B2 receptor antagonist, FR167344 by INAMURA, N, ASANO, M, SAWADA, Y, OKU, T, NAKAHARA, K, HATORI, C, SAWAI, H, HIROSUMI, J, FUJIWARA, T, KAYAKIRI, H, SATOH, S, ABE, Y, INOUE, T

“…To investigate the pathophysiological role of bradykinin and to develop a drug for inflammatory diseases, we discovered an orally active, nonpeptide bradykinin…”
Get full text

Effects of FR145237, an Acyl-CoA:cholesterol acyltransferase inhibitor, on diet-induced hypercholesterolemia in diabetic rats by Sakuma, Yuri, Hagihara, Hiroyuki, Nagayoshi, Akira, Ohne, Kazuhiko, Mutoh, Seitaro, Ito, Yoshikuni, Nakahara, Kunio, Notsu, Yoshitada, Okuhara, Masakuni

“…Recent studies have shown that acyl-CoA:cholesterol acyltransferase (ACAT) plays an important role in the initiation of diabetes-associated…”
Get full text

Effects of a nonpeptide bradykinin B 2 receptor antagonist, FR167344, on different in vivo animal models of inflammation by Asano, Masayuki, Hatori, Chie, Inamura, Noriaki, Sawai, Hiroe, Hirosumi, Jiro, Fujiwara, Tatsujiro, Nakahara, Kunio

“…The effects of a novel, potent and orally active nonpeptide bradykinin B 2 receptor antagonist, FR167344 (N ‐[N ‐[3 ‐[(3 ‐ bromo‐ 2…”
Get full text

Pharmacological characterization of a nonpeptide bradykinin B 2 receptor antagonist, FR165649, and agonist, FR190997 by Asano, Masayuki, Hatori, Chie, Sawai, Hiroe, Johki, Shigeru, Inamura, Noriaki, Kayakiri, Hiroshi, Satoh, Shigeki, Abe, Yoshito, Inoue, Takayuki, Sawada, Yuki, Mizutani, Tsuyoshi, Oku, Teruo, Nakahara, Kunio

“…The nonpeptide bradykinin (BK) B 2 receptor antagonist, FR165649 (8‐[2,6‐dichloro‐3‐[N‐[(E)‐4‐(N‐ methylcarbamoyl)cinnamidoacetyl] ‐N‐methylamino] benzyloxy]…”
Get full text

Studies of an immunomodulator, swainsonine. II. Effect of swainsonine on mouse immunodeficient system and experimental murine tumor by Kino, T, Inamura, N, Nakahara, K, Kiyoto, S, Goto, T, Terano, H, Kohsaka, M, Aoki, H, Imanaka, H

“…We examined the effect of swainsonine on antibody response to sheep red blood cells (SRBC) in immunodeficient mice which were treated with immunosuppressive…”
Get more information

Studies on WF-3161, a new antitumor antibiotic by Umehara, K, Nakahara, K, Kiyoto, S, Iwami, M, Okamoto, M, Tanaka, H, Kohsaka, M, Aoki, H, Imanaka, H

“…WF-3161 is an antitumor antibiotic produced by a strain of fungus, Petriella guttulata. The antibiotic was purified by solvent extraction and a combination of…”
Get more information

A new antitumor antibiotic, FR900840. III. Antitumor activity against experimental tumors by Nishimura, M, Nakada, H, Kawamura, I, Mizota, T, Shimomura, K, Nakahara, K, Goto, T, Yamaguchi, I, Okuhara, M

“…FR900840 [2S)-2-amino-2-carboxyethyl (3R)-2-diazo-3-hydroxybutyrate), a new antibiotic with antitumor activity was isolated from the fermentation broth of…”
Get more information

Studies on a new immunoactive peptide, FK-156. II. Fermentation, extraction and chemical and biological characterization by Gotoh, T, Nakahara, K, Nishiura, T, Hashimoto, M, Kino, T, Kuroda, Y, Okuhara, M, Kohsaka, M, Aoki, H, Imanaka, H

“…An interesting immunoactive peptide, FK-156, has been isolated from the fermentation broth of Streptomyces olivaceogriseus sp. nov. and Streptomyces violaceus…”
Get more information

Antitumor effects of novel immunoactive peptides, FK-156 and its synthetic derivatives by Izumi, S, Nakahara, K, Gotoh, T, Hashimoto, S, Kino, T, Okuhara, M, Aoki, H, Imanaka, H

“…Effects produced by intratumor or systemic application of FK-156 and its synthetic derivatives on the syngeneic P388-DBA/2 mouse system were investigated…”
Get more information

FR167653, a dual inhibitor of interleukin-1 and tumor necrosis factor-α, ameliorates endotoxin-induced shock by Yamamoto, Nobuchika, Sakai, Fumihiko, Yamazaki, Harumi, Sato, Natsuki, Nakahara, Kunio, Okuhara, Masakuni

“…Increased production of interleukin-1 and tumor necrosis factor-α (TNF-α) have been implicated in the pathophysiology of a variety of diseases including…”
Get full text

Studies on a new immunoactive peptide, FK-156. III. Structure elucidation by Kawai, Y, Nakahara, K, Gotoh, T, Uchida, I, Tanaka, H, Imanaka, H

Get more information

新規免疫抑制剤タクロリムス水和物の発見と開発 by 田中, 洋和, 中原, 邦夫, 畑中, 洋, 稲村, 典昭, 黒田, 昭雄

Get full text

Pharmacological evaluation of FK706, a novel and potent elastase inhibitor by Yamazaki, Akiko, Shinguh, Yasuhiko, Inamura, Noriaki, Nakahara, Kunio, Shirnomura, Kyoujchi, Ono, Takaharu

“…We found a novel and potent elastase inhibitor, FK706, sodium…”
Get full text

Potentiation of tumoricidal properties of murine macrophages by Nocardia rubra cell wall skeleton (N-CWS) by Inamura, N, Fujitsu, T, Nakahara, K, Abiko, M, Horii, Y, Hashimoto, S, Aoki, H

“…Intraperitoneal injection of squalene-treated cell wall skeleton of Nocardia rubra (N-CWS) caused increase in number of peritoneal exudate cells (PEC)…”
Get more information