Search Results - "Nakagomi, Rie"

Identification of a Novel Gene Family Encoding Human Liver-specific Organic Anion Transporter LST-1 by Abe, T, Kakyo, M, Tokui, T, Nakagomi, R, Nishio, T, Nakai, D, Nomura, H, Unno, M, Suzuki, M, Naitoh, T, Matsuno, S, Yawo, H

“…We have isolated a novel liver-specific organic anion transporter, LST-1, that is expressed exclusively in the human, rat, and mouse liver. LST-1 is a new gene…”
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LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers by Abe, Takaaki, Unno, Michiaki, Onogawa, Tohru, Tokui, Taro, Kondo, Tohru Noriko, Nakagomi, Rie, Adachi, Hisanobu, Fujiwara, Koh, Okabe, Mitsunori, Suzuki, Takehiro, Nunoki, Kazuo, Sato, Eiichi, Kakyo, Masayuki, Nishio, Toshiyuki, Sugita, Junichi, Asano, Naoki, Tanemoto, Masayuki, Seki, Makoto, Date, Fumiko, Ono, Katsuhiko, Kondo, Yoshiaki, Shiiba, Kenichi, Suzuki, Masanori, Ohtani, Haruo, Shimosegawa, Tooru, Iinuma, Kazuie, Nagura, Hiroshi, Ito, Sadayoshi, Matsuno, Seiki

“…Background & Aims: One approach to the development of targeted cancer chemotherapy exploits increased uptake of the agent into neoplastic cells. In this…”
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Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes by Nakai, D, Nakagomi, R, Furuta, Y, Tokui, T, Abe, T, Ikeda, T, Nishimura, K

“…Involvement of LST-1 (a human liver-specific transporter, also called OATP2) as the major transporter in the uptake of pravastatin, a…”
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Evaluation of the Usefulness of Breast Cancer Resistance Protein (BCRP) Knockout Mice and BCRP Inhibitor-Treated Monkeys to Estimate the Clinical Impact of BCRP Modulation on the Pharmacokinetics of BCRP Substrates by Karibe, Tsuyoshi, Hagihara-Nakagomi, Rie, Abe, Koji, Imaoka, Tomoki, Mikkaichi, Tsuyoshi, Yasuda, Satoru, Hirouchi, Masakazu, Watanabe, Nobuaki, Okudaira, Noriko, Izumi, Takashi

“…ABSTRACT Purpose To evaluate whether the impact of functional modulation of the breast cancer resistance protein (BCRP, ABCG2 421C>A) on human pharmacokinetics…”
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OATP1B1, OATP1B3, AND MRP2 ARE INVOLVED IN HEPATOBILIARY TRANSPORT OF OLMESARTAN, A NOVEL ANGIOTENSIN II BLOCKER by NAKAGOMI-HAGIHARA, Rie, NAKAI, Daisuke, KAWAI, Kenji, YOSHIGAE, Yasushi, TOKUI, Taro, ABE, Takaaki, IKEDA, Toshihiko

“…Hepatic uptake and biliary excretion of olmesartan, a new angiotensin II blocker, were investigated in vitro using human hepatocytes, cells expressing uptake…”
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Pravastatin, an HMG-CoA reductase inhibitor, is transported by rat organic anion transporting polypeptide, oatp2 by TOKUI, T, NAKAI, D, NAKAGOMI, R, YAWO, H, ABE, T, SUGIYAMA, Y

“…We previously demonstrated the HMG-CoA reductase inhibitor, pravastatin, is actively taken up into isolated rat hepatocytes through multispecific organic anion…”
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Molecular characterization and functional regulation of a novel rat liver-specific organic anion transporter rlst-1 by Kakyo, Masayuki, Unno, Michiaki, Tokui, Taro, Nakagomi, Rie, Nishio, Toshiyuki, Iwasashi, Hajime, Nakai, Daisuke, Seki, Makoto, Suzuki, Masanori, Naitoh, Takeshi, Matsuno, Seiki, Yawo, Hiromu, Abe, Takaaki

“…Background & Aims: Recently, we isolated a new complementary DNA (cDNA) encoding human liver-specific organic anion transporter (LST-1), representing the…”
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The HMG-CoA Reductase Inhibitor Pravastatin Stimulates Insulin Secretion through Organic Anion Transporter Polypeptides by Abe, Michiaki, Toyohara, Takafumi, Ishii, Akiko, Suzuki, Takehiro, Noguchi, Naoya, Akiyama, Yasutoshi, Shiwaku, Hiromi O., Nakagomi-Hagihara, Rie, Zheng, Guodong, Shibata, Eisuke, Souma, Tomokazu, Shindo, Tomohiko, Shima, Hirohito, Takeuchi, Yoichi, Mishima, Eikan, Tanemoto, Masayuki, Terasaki, Tetsuya, Onogawa, Tohru, Unno, Michiaki, Ito, Sadayoshi, Takasawa, Shin, Abe, Takaaki

“…The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor pravastatin has been reported to have a beneficial effect on reducing the new onset of diabetes…”
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Enhancement of the Inhibitory Activity of oatp Antisense Oligonucleotides by Incorporation of 2‘-O,4‘-C-Ethylene-Bridged Nucleic Acids (ENA) without a Loss of Subtype Selectivity by Takagi, Miho, Morita, Koji, Nakai, Daisuke, Nakagomi, Rie, Tokui, Taro, Koizumi, Makoto

“…Antisense oligonucleotides (AONs) that specifically target the genes of rat organic anion transporting polypeptide (oatp) subtypes were selected by using…”
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Immunohistochemical distribution and functional characterization of an organic anion transporting polypeptide 2 (oatp2) by Kakyo, Masayuki, Sakagami, Hiroyuki, Nishio, Toshiyuki, Nakai, Daisuke, Nakagomi, Rie, Tokui, Taro, Naitoh, Takeshi, Matsuno, Seiki, Abe, Takaaki, Yawo, Hiromu

“…The rabbit polyclonal antibody against rat organic anion transporting polypeptide 2 (oatp2) was raised and immunoaffinity-purified. Western blot analysis for…”
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Molecular Identification of a Rat Novel Organic Anion Transporter moat1, Which Transports Prostaglandin D2, Leukotriene C4, and Taurocholate by Nishio, Toshiyuki, Adachi, Hisanobu, Nakagomi, Rie, Tokui, Taro, Sato, Eiichi, Tanemoto, Masayuki, Fujiwara, Kho, Okabe, Mitsunori, Onogawa, Tohru, Suzuki, Takehiro, Nakai, Daisuke, Shiiba, Kenici, Suzuki, Masanori, Ohtani, Haruo, Kondo, Yoshiaki, Unno, Michiaki, Ito, Sadayoshi, Iinuma, Kazuie, Nunoki, Kazuo, Matsuno, Seiki, Abe, Takaaki

“…We have isolated a rat novel multispecific organic anion transporter, moat1. The isolated clones were originated by alternative splicing of the moat1 mRNA. The…”
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Design and synthesis of oatp subtype-specific antisense oligonucleotides having 2′-O,4′-C-ethylene-bridged nucleic acids (ENA™) by Takagi, Miho, Morita, Koji, Nakai, Daisuke, Nakagomi, Rie, Tokui, Taro, Koizumi, Makoto

“…To select antisense oligonucleotides (AONs) that specifically target the genes of rat organic anion transporting polypeptide (oatp) subtypes, in vitro…”
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Metabolic Stability and Uptake by Human Hepatocytes of Pitavastatin, a New Inhibitor of HMG-CoA Reductase by Fujino, Hideki, Nakai, Daisuke, Nakagomi, Rie, Saito, Motoko, Tokui, Taro, Kojima, Junji

“…Summary To gain a better understanding of the metabolic stability and transport of pitavastatin (CAS 147526-32-7), a new and potent 3-hydroxy-3-methylglutaryl…”
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Design and synthesis of oatp subtype-specific antisense oligonucleotides having 2'-O,4'-C-ethylene-bridged nucleic acids (ENA) by Takagi, Miho, Morita, Koji, Nakai, Daisuke, Nakagomi, Rie, Tokui, Taro, Koizumi, Makoto

“…To select antisense oligonucleotides (AONs) that specifically target the genes of rat organic anion transporting polypeptide (oatp) subtypes, in vitro…”
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