Search Results - "Nakagawa, Kazuhiro"

Unlabeled image analysis-based cell viability assay with intracellular movement monitoring by Nakagawa, Kazuhiro, Kishimoto, Takuya

“…The need for technologies to monitor cell health is increasing with advancements in the field of cell therapy and regenerative medicine. In this study, we…”
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The Crystal Structure of Calcium-Free Human m-Calpain Suggests an Electrostatic Switch Mechanism for Activation by Calcium by Strobl, Stefan, Fernandez-Catalan, Carlos, Braun, Marianne, Huber, Robert, Masumoto, Hajime, Nakagawa, Kazuhiro, Irie, Akihiro, Sorimachi, Hiroyuki, Bourenkow, Gleb, Bartunik, Hans, Suzuki, Koichi, Bode, Wolfram

“…Calpains (calcium-dependent cytoplasmic cysteine proteinases) are implicated in processes such as cytoskeleton remodeling and signal transduction. The 2.3-…”
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Possible Regulation of the Conventional Calpain System by Skeletal Muscle-specific Calpain, p94/Calpain 3 by Ono, Yasuko, Kakinuma, Kazumi, Torii, Fukuyo, Irie, Akihiro, Nakagawa, Kazuhiro, Labeit, Siegfried, Abe, Keiko, Suzuki, Koichi, Sorimachi, Hiroyuki

“…p94 (also called calpain 3) is the skeletal muscle-specific calpain and is considered to be a “modulator protease” in various cellular processes. Analysis of…”
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Effect of ODS-Cu Composition for Mechanical-Electromagnetic Property of Bronze-Processed Superconducting Wire by Nishijima, Gen, Minegishi, Kazuhiro, Watanabe, Kazuo, Ohata, Katsumi, Nakagawa, Kazuhiro, Iwaki, Genzo

“…The oxide dispersion strengthened copper (ODS-Cu) was composed to Cu stabilizer in Nb 3 Sn wires with/without Ta-reinforced filaments to improve the…”
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Domain II of m‐calpain is a Ca2+‐dependent cysteine protease by Hata, Shoji, Sorimachi, Hiroyuki, Nakagawa, Kazuhiro, Maeda, Tatsuya, Abe, Keiko, Suzuki, Koichi

“…Calpain, a Ca2+‐dependent cytosolic cysteine protease, proteolytically modulates specific substrates involved in Ca2+‐mediated intracellular events, such as…”
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Dissociation of m-Calpain Subunits Occurs after Autolysis of the N-Terminus of the Catalytic Subunit, and Is Not Required for Activation by Nakagawa, Kazuhiro, Masumoto, Hajime, Sorimachi, Hiroyuki, Suzuki, Koichi

“…Calpain is a heterodimeric, intracellular Ca2+-dependent, “bio-modulator” that alters the properties of substrates through site-specific proteolysis. It has…”
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NESK, a Member of the Germinal Center Kinase Family That Activates the c-Jun N-terminal Kinase Pathway and Is Expressed during the Late Stages of Embryogenesis by Nakano, Kuniko, Yamauchi, Junji, Nakagawa, Kazuhiro, Itoh, Hiroshi, Kitamura, Naomi

“…The c-Jun N-terminal kinase (JNK) signaling pathway plays a crucial role in cellular responses stimulated by stress-inducing agents and proinflammatory…”
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iPSC-derived functional human neuromuscular junctions model the pathophysiology of neuromuscular diseases by Lin, Chuang-Yu, Yoshida, Michiko, Li, Li-Tzu, Ikenaka, Akihiro, Oshima, Shiori, Nakagawa, Kazuhiro, Sakurai, Hidetoshi, Matsui, Eriko, Nakahata, Tatsutoshi, Saito, Megumu K.

“…The control of voluntary skeletal muscle contraction relies on action potentials, which send signals from the motor neuron through the neuromuscular junction…”
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Synthesis of N,N-Dialkyl-9-oxoacridine-10(9H)-carbothioamides via the Reaction of (2-Halophenyl)(2-isothiocyanatophenyl)methanones with Secondary Amines, Followed by Cyclization with NaH by Kobayashi, Kazuhiro, Nakagawa, Kazuhiro, Yuba, Shohei

“…The first preparation of acridin‐9(10H)‐ones carrying a tertiary thiocarbamoyl group at C(10), i.e., N,N‐dialkyl‐9‐oxoacridine‐10(9H)‐carbothioamides 9, is…”
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Skeletal Muscle-specific Calpain Is an Intracellular Na+-dependent Protease by Ono, Yasuko, Ojima, Koichi, Torii, Fukuyo, Takaya, Emi, Doi, Naoko, Nakagawa, Kazuhiro, Hata, Shoji, Abe, Keiko, Sorimachi, Hiroyuki

“…Because intracellular [Na+] is kept low by Na+/K+-ATPase, Na+ dependence is generally considered a property of extracellular enzymes. However, we found that…”
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Synthesis of N,N-Dialkyl-5(or 10)-oxobenzo[b][1,8 or 1,7(or 1,6)]naphthyridine-10(5H)(or 5(10H))-carbothioamides Based on the Reaction of the Respective (Chloropyridinyl)(2-isothiocyanatophenyl)methanones with Secondary Amines by Kobayashi, Kazuhiro, Nakagawa, Kazuhiro, Inouchi, Hiroki

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Interleukin-1β up-regulates TACE to enhance α-cleavage of APP in neurons: resulting decrease in Aβ production by Tachida, Yuriko, Nakagawa, Kazuhiro, Saito, Takashi, Saido, Takaomi C, Honda, Takashi, Saito, Yuko, Murayama, Shigeo, Endo, Tamao, Sakaguchi, Gaku, Kato, Akira, Kitazume, Shinobu, Hashimoto, Yasuhiro

“…The proinflammatory cytokine interleukin (IL)-1β is up-regulated in microglial cells surrounding amyloid plaques, leading to the hypothesis that IL-1β is a…”
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One-Pot Synthesis of 1,4-Oxathiino[2,3-b]quinoxalines or -pyrazines from 2,3-Dichloroquinoxaline or -pyrazine and 1-Aryl-2-bromoalkan-1-ones by Kobayashi, Kazuhiro, Konishi, Natsuki, Suzuki, Teruhiko, Nakagawa, Kazuhiro

“…An efficient one‐pot synthesis of novel heterocyclic derivatives, 2‐aryl‐1,4‐oxathiino[2,3‐b]quinoxalines or ‐pyrazines 5, via the reaction of…”
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Synthesis of 10-Aryl- and 10-(Arylmethyl)acridin-9(10H)-ones via the Reaction of (2-Fluorophenyl)(2-halophenyl)methanones with Benzenamines and Arylmethanamines by Kobayashi, Kazuhiro, Nakagawa, Kazuhiro, Yuba, Shohei, Komatsu, Toshihide

“…The reaction of 1‐fluoro‐2‐lithiobenzenes, generated from 1‐bromo‐2‐fluorobenzenes 1 and BuLi, with 2‐halobenzaldehydes and subsequent oxidation of the…”
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Detection of the CLOCK/BMAL1 heterodimer using a nucleic acid probe with cycling probe technology by Nakagawa, Kazuhiro, Yamamoto, Takuro, Yasuda, Akio

“…An isothermal signal amplification technique for specific DNA sequences, known as cycling probe technology (CPT), has enabled rapid acquisition of genomic…”
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A Convenient Synthesis of 9H-Thioxanthen-9-ones and Their Aza-Analogues by Kobayashi, Kazuhiro, Komatsu, Toshihide, Nakagawa, Kazuhiro, Hara, Erika, Yuba, Shohei

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Synthesis of 3-Substituted 4-Sulfanyl-8-methoxyisoquinolin-1(2H)-ones by the Reaction of Ethyl 2-[Lithio(sulfanyl)methyl]-6-methoxybenzoates with Aliphatic and Aromatic Nitriles by Kobayashi, Kazuhiro, Hashimoto, Hiroo, Nakagawa, Kazuhiro

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Synthesis of 1-Amino-1-aryl-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Derivatives by the Reaction of 4-Lithiopyridine-3-carbonitrile with Aromatic Tertiary Amides by Kobayashi, Kazuhiro, Nakagawa, Kazuhiro, Kozuki, Taketoshi

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Effect of ODS-Cu Composition for Mechanical-Electromagnetic Property of Bronze-Processed Nb3Sn Superconducting Wire by NISHIJIMA, Gen, MINEGISHI, Kazuhiro, WATANABE, Kazuo, OHATA, Katsumi, NAKAGAWA, Kazuhiro, IWAKI, Genzo

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In Vivo Cleavage of α2,6-Sialyltransferase by Alzheimer β-Secretase by Kitazume, Shinobu, Nakagawa, Kazuhiro, Oka, Ritsuko, Tachida, Yuriko, Ogawa, Kazuko, Luo, Yi, Citron, Martin, Shitara, Hiroshi, Taya, Choji, Yonekawa, Hiromichi, Paulson, James C., Miyoshi, Eiji, Taniguchi, Naoyuki, Hashimoto, Yasuhiro

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