Search Results - "Nakada, Emily M."

The Impact of Endoplasmic Reticulum-Associated Protein Modifications, Folding and Degradation on Lung Structure and Function by Nakada, Emily M., Sun, Rui, Fujii, Utako, Martin, James G.

“…The accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and induces the unfolded protein response (UPR) and other…”
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Detection and genomic analysis of BRAF fusions in Juvenile Pilocytic Astrocytoma through the combination and integration of multi-omic data by Zwaig, Melissa, Baguette, Audrey, Hu, Bo, Johnston, Michael, Lakkis, Hussein, Nakada, Emily M, Faury, Damien, Juretic, Nikoleta, Ellezam, Benjamin, Weil, Alexandre G, Karamchandani, Jason, Majewski, Jacek, Blanchette, Mathieu, Taylor, Michael D, Gallo, Marco, Kleinman, Claudia L, Jabado, Nada, Ragoussis, Jiannis

“…Juvenile Pilocytic Astrocytomas (JPAs) are one of the most common pediatric brain tumors, and they are driven by aberrant activation of the mitogen-activated…”
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Immune landscape of oncohistone-mutant gliomas reveals diverse myeloid populations and tumor-promoting function by Andrade, Augusto Faria, Annett, Alva, Karimi, Elham, Topouza, Danai Georgia, Rezanejad, Morteza, Liu, Yitong, McNicholas, Michael, Gonzalez Santiago, Eduardo G., Llivichuzhca-Loja, Dhana, Gehlhaar, Arne, Jessa, Selin, De Cola, Antonella, Chandarana, Bhavyaa, Russo, Caterina, Faury, Damien, Danieau, Geoffroy, Puligandla, Evan, Wei, Yuhong, Zeinieh, Michele, Wu, Qing, Hebert, Steven, Juretic, Nikoleta, Nakada, Emily M., Krug, Brian, Larouche, Valerie, Weil, Alexander G., Dudley, Roy W. R., Karamchandani, Jason, Agnihotri, Sameer, Quail, Daniela F., Ellezam, Benjamin, Konnikova, Liza, Walsh, Logan A., Pathania, Manav, Kleinman, Claudia L., Jabado, Nada

“…Histone H3-mutant gliomas are deadly brain tumors characterized by a dysregulated epigenome and stalled differentiation. In contrast to the extensive datasets…”
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Dose-dependent effects of IL-17 on IL-13-induced airway inflammatory responses and airway hyperresponsiveness by Kinyanjui, Margaret W, Shan, Jichuan, Nakada, Emily M, Qureshi, Salman T, Fixman, Elizabeth D

“…The Th2 cytokine IL-13 regulates several aspects of the asthmatic phenotype, including airway inflammation, airway hyperresponsiveness, and mucus production…”
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Protein Disulfide Isomerase A3 Regulates Influenza Neuraminidase Activity and Influenza Burden in the Lung by Chamberlain, Nicolas, Ruban, Mona, Mark, Zoe F, Bruno, Sierra R, Kumar, Amit, Chandrasekaran, Ravishankar, Souza De Lima, Dhemerson, Antos, Danielle, Nakada, Emily M, Alcorn, John F, Anathy, Vikas

“…Influenza (IAV) neuraminidase (NA) is a glycoprotein required for the viral exit from the cell. NA requires disulfide bonds for proper function. We have…”
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Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics by Chamberlain, Nicolas, Korwin-Mihavics, Bethany R, Nakada, Emily M, Bruno, Sierra R, Heppner, David E, Chapman, David G, Hoffman, Sidra M, van der Vliet, Albert, Suratt, Benjamin T, Dienz, Oliver, Alcorn, John F, Anathy, Vikas

“…Protein disulfide isomerases (PDI) are a family of redox chaperones that catalyze formation or isomerization of disulfide bonds in proteins. Previous studies…”
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Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration by Khazaei, Sima, Chen, Carol C.L., Andrade, Augusto Faria, Kabir, Nisha, Azarafshar, Pariya, Morcos, Shahir M., França, Josiane Alves, Lopes, Mariana, Lund, Peder J., Danieau, Geoffroy, Worme, Samantha, Adnani, Lata, Nzirorera, Nadine, Chen, Xiao, Yogarajah, Gayathri, Russo, Caterina, Zeinieh, Michele, Wong, Cassandra J., Bryant, Laura, Hébert, Steven, Tong, Bethany, Sihota, Tianna S., Faury, Damien, Puligandla, Evan, Jawhar, Wajih, Sandy, Veronica, Cowan, Mitra, Nakada, Emily M., Jerome-Majewska, Loydie A., Ellezam, Benjamin, Gomes, Carolina Cavalieri, Denecke, Jonas, Lessel, Davor, McDonald, Marie T., Pizoli, Carolyn E., Taylor, Kathryn, Cocanougher, Benjamin T., Bhoj, Elizabeth J., Gingras, Anne-Claude, Garcia, Benjamin A., Lu, Chao, Campos, Eric I., Kleinman, Claudia L., Garzia, Livia, Jabado, Nada

“…Germline histone H3.3 amino acid substitutions, including H3.3G34R/V, cause severe neurodevelopmental syndromes. To understand how these mutations impact brain…”
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Comprehensive Genomic Analysis of Cemento-Ossifying Fibroma by Gomez, Ricardo Santiago, El Mouatani, Ahmed, Duarte-Andrade, Filipe Fideles, Pereira, Thais dos Santos Fontes, Guimarães, Letícia Martins, Gayden, Tenzin, Faury, Damien, Nakada, Emily M., Langlois, Sylvie, Sinnett, Daniel, de Castro, Wagner Henriques, Diniz, Marina Gonçalves, Jabado, Nada, Gomes, Carolina Cavalieri

“…Cemento-ossifying fibroma (COF) of the jaws is currently classified as a benign mesenchymal odontogenic tumor, and only targeted approaches have been used to…”
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Adjuvant-dependent regulation of interleukin-17 expressing γδ T cells and inhibition of Th2 responses in allergic airways disease by Nakada, Emily M, Shan, Jichuan, Kinyanjui, Margaret W, Fixman, Elizabeth D

“…Th2 immune responses are linked primarily to mild and moderate asthma, while Th17 cells, Interleukin-17A (IL-17) and neutrophilia have been implicated in more…”
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Bevacizumab in the Treatment of Refractory Brain Edema in High-grade Glioma by Alsahlawi, Aysha K, Michaud-Couture, Claudie, Lachance, Alexandre, Bergeron-Gravel, Samuel, Létourneau, Mélanie, Bourget, Catherine, Gould, Peter V, Giannakouros, Panagiota, Nakada, Emily M, Faury, Damien, Crevier, Louis, Bouffet, Éric, Jabado, Nada, Larouche, Valérie, Renzi, Samuele

“…We report the case of a 14-year-old boy with a steroid-dependent refractory tumor whose longstanding dexamethasone treatment was successfully discontinued…”
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Adjuvant-dependent regulation of interleukin-17 expressing gamma delta T cells and inhibition of Th2 responses in allergic airways disease by Nakada, Emily M, Shan, Jichuan, Kinyanjui, Margaret W, Fixman, Elizabeth D

“…Background: Th2 immune responses are linked primarily to mild and moderate asthma, while Th17 cells, Interleukin-17A (IL-17) and neutrophilia have been…”
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Effect of a chemical chaperone, tauroursodeoxycholic acid, on HDM-induced allergic airway disease by Siddesha, Jalahalli M, Nakada, Emily M, Mihavics, Bethany R, Hoffman, Sidra M, Rattu, Gurkiranjit K, Chamberlain, Nicolas, Cahoon, Jonathon M, Lahue, Karolyn G, Daphtary, Nirav, Aliyeva, Minara, Chapman, David G, Desai, Dhimant H, Poynter, Matthew E, Anathy, Vikas

“…Endoplasmic reticulum (ER) stress-induced unfolded protein response plays a critical role in inflammatory diseases, including allergic airway disease. However,…”
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CD4+ T cells enhance the unloaded shortening velocity of airway smooth muscle by altering the contractile protein expression by Matusovsky, Oleg S., Nakada, Emily M., Kachmar, Linda, Fixman, Elizabeth D., Lauzon, Anne‐Marie

“…Key points Activated CD4+ T cells enhance the contractility of airway smooth muscle. In order to enhance contractility, contact between CD4+ T cells and smooth…”
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Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresponsiveness by inhibiting UPR transducers by Nakada, Emily M, Bhakta, Nirav R, Korwin-Mihavics, Bethany R, Kumar, Amit, Chamberlain, Nicolas, Bruno, Sierra R, Chapman, David G, Hoffman, Sidra M, Daphtary, Nirav, Aliyeva, Minara, Irvin, Charles G, Dixon, Anne E, Woodruff, Prescott G, Amin, Shantu, Poynter, Matthew E, Desai, Dhimant H, Anathy, Vikas

“…Conjugated bile acids (CBAs), such as tauroursodeoxycholic acid (TUDCA), are known to resolve the inflammatory and unfolded protein response (UPR) in…”
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TMIC-04. IMMUNE PROFILING OF PEDIATRIC ONCOHISTONE GLIOMAS REVEALS DIVERSE MYELOID POPULATIONS AND TUMOR-PROMOTING BEHAVIORS by Andrade, Augusto Faria, Topouza, Danai, McNicholas, Michael, Gonzalez Santiago, Eduardo G, De Cola, Antonella, Gehlhaar, Arne, Jessa, Selin, Chandarana, Bhavyaa, Russo, Caterina, Faury, Damien, Danieau, Geoffroy, Zeinieh, Michele, Krug, Brian, Wei, Yuhong, Wu, Qing, Nakada, Emily M, Juretic, Nikoleta, Larouche, Valerie, Weil, Alexander G, Dudley, Roy, Karamchandani, Jason, Agnihotri, Sameer, Ellezam, Benjamin, Quail, Daniela, Konnikova, Yelizaveta, Kleinman, Claudia, Walsh, Logan, Pathania, Manav, Jabado, Nada

“…Abstract Pediatric high-grade gliomas pHGG are lethal and frequently bear missense mutations in histone H3, which drive tumorigenesis by altering the epigenome…”
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Targeting Differentially Expressed UPR Mediators in Mucin‐rich Colorectal Cancers and Conventional Colorectal Adenocarcinomas by Nakada, Emily M., Bruno, Sierra R., Miller, Jill, Korwin‐Mihavics, Bethany, Chamberlain, Nicolas L., Ramsey, Jon, Zenali, Maryam, Ades, Steven, Anathy, Vikas

“…Background Despite the improved 5‐year survival rate, colorectal cancer (CRC) is the second leading cause of cancer deaths in the United States and is…”
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Allergen‐Induced Endoplasmic Reticulum Stress Regulates Lung Inflammation and Fibrosis by Mariswamy, Siddesha Jalahalli, Nakada, Emily M, Mihavics, Bethany, Hoffman, Sidra, Chapman, David, Irvin, Charles G, Dixon, Anne, Poynter, Matthew, Anathy, Vikas

“…Abstract only Background The endoplasmic reticulum (ER) stress is known to play a critical role in many inflammatory diseases including asthma. One of the…”
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In Vitro Smooth Muscle Hypercontractility Induced by Cd4+ T Cells is Transient by Matusovsky, Oleg S., Nakada, Emily M., Kachmar, Linda, Fixman, Elizabeth D., Lauzon, Anne-Marie

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Contact between Cd4+ T Cells and Smooth Muscle Tissue Enhances Contractile Function by Matusovsky, Oleg S., Nakada, Emily M., Kachmar, Linda, Fixman, Elizabeth, Lauzon, Anne-Marie

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Adjuvant-dependent regulation of interleukin-17 expressing [gamma][delta] T cells and inhibition of Th2 responses in allergic airways disease by Nakada, Emily M, Shan, Jichuan, Kinyanjui, Margaret W, Fixman, Elizabeth D

“…Background Th2 immune responses are linked primarily to mild and moderate asthma, while Th17 cells, Interleukin-17A (IL-17) and neutrophilia have been…”
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