Quality of Life of Patients with Unruptured Intracranial Aneurysms Before and After Endovascular Coiling: A HEAT Trial Secondary Study and Systematic Review of the Literature

Quality of Life of Patients with Unruptured Intracranial Aneurysms Before and After Endovascular Coiling: A HEAT Trial Secondary Study and Systematic Review of the Literature

The study of quality of life (QOL) in patients with asymptomatic diseases receiving interventional treatment provides an essential metric for the assessment of procedural benefits in the surgical patient population. In this study, we analyzed QOL data collected from patients with unruptured intracra...

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Bibliographic Details
Published in:World neurosurgery Vol. 146; pp. e492 - e500
Main Authors: Abi-Aad, Karl R., Rahme, Rudy J., Syal, Arjun, Patra, Devi P., Hudson, Miles, Richter, Kent R., Ward, Jennifer D., Knis, Jason, Nak, Yak, Turcotte, Evelyn, Welz, Matthew E., Winter, JoDee, Krishna, Chandan, Chong, Brian, Bendok, Bernard R.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-02-2021
Subjects:
Quality of life
SF-36
Short-form 36
Unruptured intracranial aneurysms
Unruptured intracranial aneurysms
GH
UIA
BP
Quality of life
SF-36
QOL
EWB
HEAT
RE
BPC
PF
Short-form 36
HES
RP
BMI
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Summary:The study of quality of life (QOL) in patients with asymptomatic diseases receiving interventional treatment provides an essential metric for the assessment of procedural benefits in the surgical patient population. In this study, we analyzed QOL data collected from patients with unruptured intracranial aneurysms (UIAs) before and after endovascular coiling in the HEAT Trial, alongside a systematic review on QOL in unruptured brain aneurysms. HEAT was a randomized controlled trial comparing recurrence rates in aneurysms treated with either bare platinum coils or hydrogel coils. Patients enrolled in this trial completed a short form−36 (SF-36) QOL questionnaire before treatment and at the 3- to 12- and 18- to 24-month follow-ups. The change in QOL before and after treatment was assessed. Regression analysis evaluated the effect of select baseline characteristics on QOL change. A total of 270 patients were eligible for analysis. There was an increase in the role physical (P = 0.043), vitality (P = 0.022), and emotional well-being (P < 0.001) QOL components at the 18- to 24-month follow-up compared with baseline scores. Regression analysis showed that age younger than 60 and absence of serious adverse events were associated with improved social functioning and vitality. The literature review showed a mixed effect of intervention on QOL in patients with UIAs. Our analysis has revealed that patients with 3- to 14-mm UIAs had improvements in some physical and emotional components of QOL at 18–24 months following aneurysm coiling in the HEAT study. The literature remains indeterminate on this issue. Further studies are needed to better understand the effects of the diagnosis of UIAs and their treatment on QOL.
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ISSN:1878-8750
1878-8769
DOI:10.1016/j.wneu.2020.10.120