Search Results - "Najy, Abdo J."

The Ectodomain Shedding of E-cadherin by ADAM15 Supports ErbB Receptor Activation by Najy, Abdo J., Day, Kathleen C., Day, Mark L.

“…The zinc-dependent disintegrin metalloproteinases (a disintegrin and metalloproteinases (ADAMs) have been implicated in several disease processes, including…”
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p62/SQSTM1-induced caspase-8 aggresomes are essential for ionizing radiation-mediated apoptosis by Lee, Su Hyun, Cho, Won Jin, Najy, Abdo J., Saliganan, Allen-Dexter, Pham, Tri, Rakowski, Joseph, Loughery, Brian, Ji, Chang Hoon, Sakr, Wael, Kim, Seongho, Kato, Ikuko, Chung, Weon Kuu, Kim, Harold E., Kwon, Yong Tae, Kim, Hyeong-Reh C.

“…The autophagy–lysosome pathway and apoptosis constitute vital determinants of cell fate and engage in a complex interplay in both physiological and…”
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Platelet-derived growth factor-C (PDGF-C) activation by serine proteases: implications for breast cancer progression by Hurst, Jr, Newton J, Najy, Abdo J, Ustach, Carolyn V, Movilla, Lisa, Kim, Hyeong-Reh Choi

“…The PDGF (platelet-derived growth factor) family members are potent mitogens for cells of mesenchymal origin and serve as important regulators of cell…”
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HPV-associated differential regulation of tumor metabolism in oropharyngeal head and neck cancer by Jung, Young-Suk, Najy, Abdo J, Huang, Wei, Sethi, Seema, Snyder, Michael, Sakr, Wael, Dyson, Gregory, Hüttemann, Maik, Lee, Icksoo, Ali-Fehmi, Rouba, Franceschi, Silvia, Struijk, Linda, Kim, Harold E, Kato, Ikuko, Kim, Hyeong-Reh Choi

“…HPV-positive oropharyngeal cancer patients experience significantly lower locoregional recurrence and higher overall survival in comparison with HPV-negative…”
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Differential tumorigenic potential and matriptase activation between PDGF B versus PDGF D in prostate cancer by Najy, Abdo J, Won, Joshua J, Movilla, Lisa S, Kim, Hyeong-Reh C

“…The platelet-derived growth factors (PDGF A, B, C, and D) and their receptors (α-PDGFR and β-PDGFR) play an indispensible role in physiologic and pathologic…”
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Regulation of Tumor Metabolism and Extracellular Acidosis by the TIMP-10-CD63 Axis in Breast Carcinoma by Najy, Abdo J, Jung, Young-Suk, Kim, Seongho, Fridman, Rafael, Kim, Hyeong-Reh C

“…A hallmark of malignant solid tumor is extracellular acidification coupled with metabolic switch to aerobic glycolysis. Using the human MCF10A progression…”
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A Critical Role of the PTEN/PDGF Signaling Network for the Regulation of Radiosensitivity in Adenocarcinoma of the Prostate by Christensen, Michael, MD, Najy, Abdo J., PhD, Snyder, Michael, PhD, Movilla, Lisa S., BS, Kim, Hyeong-Reh Choi, PhD

“…Purpose Loss or mutation of the phosphate and tensin homologue (PTEN) is a common genetic abnormality in prostate cancer (PCa) and induces platelet-derived…”
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E3 ligase HUWE1 promotes PDGF D-mediated osteoblastic differentiation of mesenchymal stem cells by effecting polyubiquitination of β-PDGFR by Pham, Tri, Najy, Abdo J., Kim, Hyeong-Reh C.

“…Mesenchymal stem cells (MSCs) are adult stem cell populations and exhibit great potential in regenerative medicine and oncology. Platelet-derived growth…”
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An Autophagy-Targeting Chimera Induces Degradation of Androgen Receptor Mutants and AR-v7 in Castration-Resistant Prostate Cancer by Bae, Tae Hyun, Sung, Ki Woon, Pham, Tri M., Najy, Abdo J., Zamiri, Alaleh, Jang, Hyejeong, Mun, Su Ran, Kim, Seongho, Kwon, Ha Kyoung, Son, Yeon Sung, Shi, Dongping, Kregel, Steven, Heath, Elisabeth I., Cher, Michael L., Kwon, Yong Tae, Kim, Hyeong-Reh C.

“…Abstract Genetic alterations play a pivotal role in various human diseases, particularly cancer. The androgen receptor (AR) is a crucial transcription factor…”
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Establishment of Structure-Function Relationship of Tissue Inhibitor of Metalloproteinase-1 for Its Interaction with CD63: Implication for Cancer Therapy by Warner, Richard B., Najy, Abdo J., Jung, Young Suk, Fridman, Rafael, Kim, Seongho, Kim, Hyeong-Reh Choi

“…Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a pleiotropic protein, promoting both tumor-suppressive and tumor-promoting activities. While TIMP-1 is…”
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Involvement of Bid in the crosstalk between ferroptotic agent‐induced ER stress and TRAIL‐induced apoptosis by Kim, Jin Hong, Najy, Abdo J., Li, Jian, Luo, Xu, Kim, Hyeong‐Reh C., Choudry, Mohammad Haroon Asif, Lee, Yong J.

“…Tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) induces death receptor‐mediated extrinsic apoptosis, specifically in cancer cells, and Bid…”
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The production of recombinant platelet‐derived growth factor D using the second generation modified vaccinia Ankara viral system by Najy, Abdo J., Pham, Tri, Pradeau‐Aubreton, Karine, Drillien, Robert, Kim, Hyeong‐Reh C.

“…The vaccinia virus expression system is known for the efficient production of recombinant proteins with “appropriate” posttranslational modification using…”
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TIMP-1 via TWIST1 induces EMT phenotypes in human breast epithelial cells by D'Angelo, Rosemarie Chirco, Liu, Xu-Wen, Najy, Abdo J, Jung, Young Suk, Won, Joshua, Chai, Karl X, Fridman, Rafael, Kim, Hyeong-Reh Choi

“…Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates intracellular signaling networks for inhibition of apoptosis. Tetraspanin (CD63), a cell surface…”
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ADAM15 Supports Prostate Cancer Metastasis by Modulating Tumor Cell-Endothelial Cell Interaction by NAJY, Abdo J, DAY, Kathleen C, DAY, Mark L

“…Using human tumor and cDNA microarray technology, we have recently shown that the ADAM15 disintegrin is significantly overexpressed during the metastatic…”
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Matriptase activation and shedding through PDGF-D-mediated extracellular acidosis by Najy, Abdo J, Dyson, Gregory, Jena, Bhanu P, Lin, Chen-Yong, Kim, Hyeong-Reh C

“…Activation of β-platelet-derived growth factor receptor (β-PDGFR) is associated with prostate cancer (PCa) progression and recurrence after prostatectomy…”
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Photodynamic Therapy as a Potent Radiosensitizer in Head and Neck Squamous Cell Carcinoma by Cho, Won Jin, Kessel, David, Rakowski, Joseph, Loughery, Brian, Najy, Abdo J, Pham, Tri, Kim, Seongho, Kwon, Yong Tae, Kato, Ikuko, Kim, Harold E, Kim, Hyeong-Reh C

“…Despite recent advances in therapeutic modalities such as radiochemotherapy, the long-term prognosis for patients with advanced head and neck squamous cell…”
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SQSTM1/p62 as a therapeutic target in cancer by Kim, Hyeong-Reh C., Najy, Abdo J., Kim, Seongho, Kwon, Yong Tae

“…Cell survival depends on dynamic interactions among the signaling pathways that control the endoplasmic reticulum (ER) stress response,…”
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The interaction between androgen receptor and PDGF-D in the radiation response of prostate carcinoma by Paximadis, Peter, Najy, Abdo J., Snyder, Michael, Kim, Hyeong-Reh

“…PURPOSE To determine the functional relationship between androgen receptor (AR) and PDGF D as it relates to the radiation response of PTEN‐null prostate cancer…”
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An oncogenic activity of PDGF-C and its splice variant in human breast cancer by Bottrell, Alyssa, Meng, Yong Hong, Najy, Abdo J., Hurst, Newton, Kim, Seongho, Kim, Chong Jai, Kim, Eun-Sook, Moon, Aree, Kim, Eun Joo, Park, So Yeon, Kim, Hyeong-Reh Choi

“…Despite strong evidence for the involvement of PDGF signaling in breast cancer, little is known about the PDGF ligand responsible for PDGFR activation during…”
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Gene expression analysis of bone metastasis and circulating tumor cells from metastatic castrate-resistant prostate cancer patients by Cho, Won Jin, Oliveira, Daniel S M, Najy, Abdo J, Mainetti, Leandro E, Aoun, Hussein D, Cher, Michael L, Heath, Elisabeth, Kim, Hyeong-Reh C, Bonfil, R Daniel

“…Characterization of genes linked to bone metastasis is critical for identification of novel prognostic or predictive biomarkers and potential therapeutic…”
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