Search Results - "Najumudeen, A K"

Cancer stem cell drugs target K-ras signaling in a stemness context by Najumudeen, A K, Jaiswal, A, Lectez, B, Oetken-Lindholm, C, Guzmán, C, Siljamäki, E, Posada, I M D, Lacey, E, Aittokallio, T, Abankwa, D

“…Cancer stem cells (CSCs) are considered to be responsible for treatment relapse and have therefore become a major target in cancer research. Salinomycin is the…”
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A RAC-GEF network critical for early intestinal tumourigenesis by Pickering, K. A., Gilroy, K., Cassidy, J. W., Fey, S. K., Najumudeen, A. K., Zeiger, L. B., Vincent, D. F., Gay, D. M., Johansson, J., Fordham, R. P., Miller, B., Clark, W., Hedley, A., Unal, E. B., Kiel, C., McGhee, E., Machesky, L. M., Nixon, C., Johnsson, A. E., Bain, M., Strathdee, D., van Hoof, S. R., Medema, J. P., Anderson, K. I., Brachmann, S. M., Stucke, V. M., Malliri, A., Drysdale, M., Turner, M., Serrano, L., Myant, K., Campbell, A. D., Sansom, O. J.

“…RAC1 activity is critical for intestinal homeostasis, and is required for hyperproliferation driven by loss of the tumour suppressor gene Apc in the murine…”
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NOTUM from Apc-mutant cells biases clonal competition to initiate cancer by Flanagan, Dustin J., Pentinmikko, Nalle, Luopajärvi, Kalle, Willis, Nicky J., Gilroy, Kathryn, Raven, Alexander P., Mcgarry, Lynn, Englund, Johanna I., Webb, Anna T., Scharaw, Sandra, Nasreddin, Nadia, Hodder, Michael C., Ridgway, Rachel A., Minnee, Emma, Sphyris, Nathalie, Gilchrist, Ella, Najumudeen, Arafath K., Romagnolo, Beatrice, Perret, Christine, Williams, Ann C., Clevers, Hans, Nummela, Pirjo, Lähde, Marianne, Alitalo, Kari, Hietakangas, Ville, Hedley, Ann, Clark, William, Nixon, Colin, Kirschner, Kristina, Jones, E. Yvonne, Ristimäki, Ari, Leedham, Simon J., Fish, Paul V., Vincent, Jean-Paul, Katajisto, Pekka, Sansom, Owen J.

“…The tumour suppressor APC is the most commonly mutated gene in colorectal cancer. Loss of Apc in intestinal stem cells drives the formation of adenomas in mice…”
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