Search Results - "Najarian, Diana"

Nonclinical Pharmacokinetics and Absorption, Distribution, Metabolism, and Excretion of Givosiran, the First Approved N -Acetylgalactosamine-Conjugated RNA Interference Therapeutic by Li, Jing, Liu, Ju, Zhang, Xuemei, Clausen, Valerie, Tran, Chris, Arciprete, Michael, Wang, Qianfan, Rocca, Carrie, Guan, Li-Hua, Zhang, Guodong, Najarian, Diana, Xu, Yuanxin, Smith, Peter, Wu, Jing-Tao, Chong, Saeho

“…Givosiran is an -acetylgalactosamine-conjugated RNA interference therapeutic that targets 5'-aminolevulinate synthase 1 mRNA in the liver and is currently…”
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A comparison study of bioanalytical methods for detection and characterization of anti-velaglucerase alfa antibodies by Najarian, Diana R, Hilton, Kelly, McCauley, Thomas, Qiu, Yongchang

“…To provide more efficient and timely immunogenicity testing service to support routine patient care, the original complex testing algorithm for evaluation of…”
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Oligonucleotide quantification and metabolite profiling by high-resolution and accurate mass spectrometry by Liu, Ju, Li, Jing, Tran, Chris, Aluri, Krishna, Zhang, Xuemei, Clausen, Valerie, Zlatev, Ivan, Guan, Lihua, Chong, Saeho, Charisse, Klaus, Wu, Jing-Tao, Najarian, Diana, Xu, Yuanxin

“…Advancements in RNA interference therapeutics have triggered development of improved bioanalytical methods for oligonucleotide metabolite profiling and…”
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Discovery of a novel deaminated metabolite of a single-stranded oligonucleotide in vivo by mass spectrometry by Li, Jing, Liu, Ju, Enders, Jennifer, Arciprete, Michael, Tran, Chris, Aluri, Krishna, Guan, Li-Hua, O'Shea, Jonathan, Bisbe, Anna, Charissé, Klaus, Zlatev, Ivan, Najarian, Diana, Xu, Yuanxin

“…A novel single-stranded deaminated oligonucleotide metabolite resulting from a REVERSIR™ oligonucleotide was discovered and identified in monkey liver after…”
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An inter-laboratory comparison study of detection and characterization of anti-velaglucerase Alfa antibodies by Najarian, Diana, Hilton, Kelly, McCauley, Thomas, Qiu, Yongchang

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Evaluation of electrophoretic mobility shift assay as a method to determine plasma protein binding of siRNA by Rocca, Carrie, Dennin, Sean, Gu, Yongli, Kim, Joohwan, Chigas, Samantha, Najarian, Diana, Chong, Saeho, Gutierrez, Shannon, Butler, James, Charisse, Klaus, Robbie, Gabriel, Xu, Yuanxin, Brown, Kirk

“…The electrophoretic mobility shift assay (EMSA) was evaluated as an alternative to ultrafiltration (UF) to assess plasma protein binding (PPB) of small…”
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Sequence and expression of four mutant asparic acid tRNA genes from the mitochondria of Saccharomyces cerevisiae by Najarian, Diana, Shu, Hsiao Hsueh, Martin, Nancy C.

“…Expression of the mitochondrial tRNA Asp gene of Saccharomyces cerevisiae has been examined in five syn− mutants known to affect tRNA Asp function, and in a…”
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Isolation and Characterization of MODS, a Gene Required for Isopentenylation of Cytoplasmic and Mitochondrial tRNAs of Saccharomyces cerevisiae by Dihanich, Melitta E., Najarian, Diana, Clark, Robert, Gillman, Edwin C., Martin, Nancy C., Hopper, Anita K.

“…The mod5-1 mutation is a nuclear mutation in Saccharomyces cerevisiae that reduces the biosynthesis of N 6 -(Δ 2 -isopentenyl)adenosine in both cytoplasmic and…”
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DNA Sequence and Transcript Mapping of MOD5: Features of the 5′ Region Which Suggest Two Translational Starts by Najarian, Diana, Dihanich, Melitta E., Martin, Nancy C., Hopper, Anita K.

“…A mutation in the yeast nuclear gene MOD5 drastically reduces the biosynthesis of the modified base isopentenyladenosine in tRNAs located in different cellular…”
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