Fabrication of poly(ethylene glycol) hydrogels containing vertically and horizontally aligned graphene using dielectrophoresis: An experimental and modeling study

Fabrication of poly(ethylene glycol) hydrogels containing vertically and horizontally aligned graphene using dielectrophoresis: An experimental and modeling study

We incorporated bovine serum albumin (BSA)-functionalized graphene in poly(ethylene glycol) diacrylate (PEG) hydrogels. The graphene alignment in PEG hydrogels was changed using dielectrophoresis (DEP) forces. Effect of graphene concentration (2.55 and 5.1 mg/mL) and alignment (vertical and horizont...

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Bibliographic Details
Published in:Carbon (New York) Vol. 123; pp. 460 - 470
Main Authors: Ahadian, Samad, Naito, Ushio, Surya, Velappa Jayaraman, Darvishi, Sorour, Estili, Mehdi, Liang, Xiaobin, Nakajima, Ken, Shiku, Hitoshi, Kawazoe, Yoshiyuki, Matsue, Tomokazu
Format: Journal Article
Language:English
Published: New York Elsevier Ltd 01-10-2017
Elsevier BV
Subjects:
Alignment
Biomedical engineering
Biomedical materials
Dielectrophoresis
Dipole moments
Electric fields
Electrical resistivity
Gels
Graphene
Hydrogel
Hydrogels
Mechanical properties
Modulus of elasticity
Peptides
Poly(ethylene glycol)
Polyethylene glycol
Rodents
Serum albumin
Stem cells
Studies
Tissues
Viability
Alignment
Hydrogel
Dielectrophoresis
Graphene
Poly(ethylene glycol)
Stem cells
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Summary:We incorporated bovine serum albumin (BSA)-functionalized graphene in poly(ethylene glycol) diacrylate (PEG) hydrogels. The graphene alignment in PEG hydrogels was changed using dielectrophoresis (DEP) forces. Effect of graphene concentration (2.55 and 5.1 mg/mL) and alignment (vertical and horizontal) on electrical and mechanical properties of hybrid graphene-PEG gels was evaluated. In addition, the molecular interaction of BSA peptides with graphene in the presence and absence of an electric field was assessed. The incorporation of graphene in PEG improved mechanical properties of hybrid gels. Dielectrophoretically aligned graphene-PEG hydrogels showed an anisotropic electrical conductivity. Young's modulus of 5.1 mg/mL graphene-PEG was almost three times higher than that of pristine PEG. Viability and proliferation of mouse embryonic stem cells on graphene-PEG gels were comparable with control PEG hydrogels. Ab initio calculations showed longer peptides had higher binding affinity towards graphene and caused a change in dipole moment due to the presence of electric field. The electric field also expanded graphene and peptide chains, which confirms the graphene alignment using DEP forces. Hybrid aligned graphene-PEG hydrogels may serve as functional biomaterials to engineer biological tissues and fabricate biomedical devices. [Display omitted]
ISSN:0008-6223
1873-3891
DOI:10.1016/j.carbon.2017.07.082