Evaluation of acquired color vision deficiency in glaucoma using the Rabin cone contrast test

Evaluation of acquired color vision deficiency in glaucoma using the Rabin cone contrast test

To evaluate acquired color vision deficiency in glaucoma by using the Rabin cone contrast test (RCCT). Twenty-seven eyes of 27 patients with glaucoma (glaucoma group) and 27 eyes of 27 normal subjects (control group) were included in this study. Long (L), medium (M), and short (S) CCT scores (L CCTs...

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Bibliographic Details
Published in:Investigative ophthalmology & visual science Vol. 55; no. 10; pp. 6686 - 6690
Main Authors: Niwa, Yuichi, Muraki, Sanae, Naito, Fumiyuki, Minamikawa, Takayuki, Ohji, Masahito
Format: Journal Article
Language:English
Published: United States 28-08-2014
Subjects:
Color Vision - physiology
Color Vision Defects - diagnosis
Color Vision Defects - etiology
Color Vision Defects - physiopathology
Female
Glaucoma - complications
Glaucoma - pathology
Glaucoma - physiopathology
Humans
Male
Middle Aged
Retinal Cone Photoreceptor Cells - pathology
Retinal Ganglion Cells - pathology
Tomography, Optical Coherence - methods
Visual Field Tests
Visual Fields
cone sensitivity
glaucoma
color vision
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Summary:To evaluate acquired color vision deficiency in glaucoma by using the Rabin cone contrast test (RCCT). Twenty-seven eyes of 27 patients with glaucoma (glaucoma group) and 27 eyes of 27 normal subjects (control group) were included in this study. Long (L), medium (M), and short (S) CCT scores (L CCTs, M CCTs, and S CCTs, respectively) were measured using the RCCT in both groups. Visual field examinations were performed with Humphrey automated perimetry using the Swedish interactive thresholding algorithm 30-2, and the mean deviation (MD) was evaluated. The macular ganglion cell/inner plexiform layer (GCIPL) thickness was measured using high-definition optical coherence tomography in the glaucoma group. The mean M CCTs and S CCTs in the glaucoma group were significantly lower (P<0.05 for both comparisons) than in the control group (M CCTs, 80.7±16.8 vs. 91.9±8.22; S CCTs, 83.9±19.5 vs. 97.4±3.77, respectively); the L CCTs did not differ significantly (P=0.065) from those of the controls (91.8±12.8 vs. 97.4±3.50, respectively). The M CCTs and S CCTs were correlated significantly with those of MD (M CCTs, r=0.47; S CCTs, r=0.44; P<0.05 for both comparisons) and GCIPL thickness (M CCTs, r=0.70; P<0.0001; S CCTs, r=0.57; P<0.01). The chromatic discrimination thresholds measured by RCCT in the glaucoma group were significantly different from those measured in the control group and were correlated with the MD and GCIPL thickness. The RCCT may be useful for evaluating acquired color vision deficiency in glaucoma and may help advance current understanding of the pathophysiology of glaucomatous damage.
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ISSN:1552-5783
1552-5783
DOI:10.1167/iovs.14-14079