Search Results - "Nairn, Brittany L."

The Response of Acinetobacter baumannii to Zinc Starvation by Nairn, Brittany L., Lonergan, Zachery R., Wang, Jiefei, Braymer, Joseph J., Zhang, Yaofang, Calcutt, M. Wade, Lisher, John P., Gilston, Benjamin A., Chazin, Walter J., de Crécy-Lagard, Valerie, Giedroc, David P., Skaar, Eric P.

“…Zinc (Zn) is an essential metal that vertebrates sequester from pathogens to protect against infection. Investigating the opportunistic pathogen Acinetobacter…”
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An Acinetobacter baumannii, Zinc-Regulated Peptidase Maintains Cell Wall Integrity during Immune-Mediated Nutrient Sequestration by Lonergan, Zachery R., Nairn, Brittany L., Wang, Jiefei, Hsu, Yen-Pang, Hesse, Laura E., Beavers, William N., Chazin, Walter J., Trinidad, Jonathan C., VanNieuwenhze, Michael S., Giedroc, David P., Skaar, Eric P.

“…Acinetobacter baumannii is an important nosocomial pathogen capable of causing wound infections, pneumonia, and bacteremia. During infection, A. baumannii must…”
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Streptococcus gordonii Type I Lipoteichoic Acid Contributes to Surface Protein Biogenesis by Lima, Bruno P, Kho, Kelvin, Nairn, Brittany L, Davies, Julia R, Svensäter, Gunnel, Chen, Ruoqiong, Steffes, Amanda, Vreeman, Gerrit W, Meredith, Timothy C, Herzberg, Mark C

“…Lipoteichoic acid (LTA) is an abundant polymer of the Gram-positive bacterial cell envelope and is essential for many species. Whereas the exact function of…”
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Iron Acquisition Systems of Gram-negative Bacterial Pathogens Define TonB-Dependent Pathways to Novel Antibiotics by Klebba, Phillip E, Newton, Salete M. C, Six, David A, Kumar, Ashish, Yang, Taihao, Nairn, Brittany L, Munger, Colton, Chakravorty, Somnath

“…Iron is an indispensable metabolic cofactor in both pro- and eukaryotes, which engenders a natural competition for the metal between bacterial pathogens and…”
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Multi-metal Restriction by Calprotectin Impacts De Novo Flavin Biosynthesis in Acinetobacter baumannii by Wang, Jiefei, Lonergan, Zachery R, Gonzalez-Gutierrez, Giovanni, Nairn, Brittany L, Maxwell, Christina N, Zhang, Yixiang, Andreini, Claudia, Karty, Jonathan A, Chazin, Walter J, Trinidad, Jonathan C, Skaar, Eric P, Giedroc, David P

“…Calprotectin (CP) inhibits bacterial viability through extracellular chelation of transition metals. However, how CP influences general metabolism remains…”
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Fluorescent sensors of siderophores produced by bacterial pathogens by Kumar, Ashish, Yang, Taihao, Chakravorty, Somnath, Majumdar, Aritri, Nairn, Brittany L., Six, David A., Marcondes dos Santos, Naara, Price, Sarah L., Lawrenz, Matthew B., Actis, Luis A., Marques, Marilis, Russo, Thomas A., Newton, Salete M., Klebba, Phillip E.

“…Siderophores are iron-chelating molecules that solubilize Fe3+ for microbial utilization and facilitate colonization or infection of eukaryotes by liberating…”
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Effects of fluid shear stress on oral biofilm formation and composition and the transcriptional response of Streptococcus gordonii by Nairn, Brittany L., Lima, Bruno P., Chen, Ruoqiong, Yang, Judy Q., Wei, Guanju, Chumber, Ashwani K., Herzberg, Mark C.

“…Biofilms are subjected to many environmental pressures that can influence community structure and physiology. In the oral cavity, and many other environments,…”
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Universal fluorescent sensors of high-affinity iron transport, applied to ESKAPE pathogens by Chakravorty, Somnath, Shipelskiy, Yan, Kumar, Ashish, Majumdar, Aritri, Yang, Taihao, Nairn, Brittany L., Newton, Salete M., Klebba, Phillip E.

“…Sensitive assays of biochemical specificity, affinity, and capacity are valuable both for basic research and drug discovery. We created fluorescent sensors…”
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Uncovering Roles of Streptococcus gordonii SrtA-Processed Proteins in the Biofilm Lifestyle by Nairn, Brittany L, Lee, Grace T, Chumber, Ashwani K, Steck, Patrick R, Mire, Mahmoud O, Lima, Bruno P, Herzberg, Mark C

“…is a commensal oral organism. Harmless in the oral cavity, is an opportunistic pathogen. adheres to body surfaces using surface adhesive proteins (adhesins),…”
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Fluorescence High-Throughput Screening for Inhibitors of TonB Action by Nairn, Brittany L, Eliasson, Olivia S, Hyder, Dallas R, Long, Noah J, Majumdar, Aritri, Chakravorty, Somnath, McDonald, Peter, Roy, Anuradha, Newton, Salete M, Klebba, Phillip E

“…Gram-negative bacteria acquire ferric siderophores through TonB-dependent outer membrane transporters (TBDT). By fluorescence spectroscopic hgh-throughput…”
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