Search Results - "Nair, Jithin D."

Surface biotinylation of primary neurons to monitor changes in AMPA receptor surface expression in response to kainate receptor stimulation by Nair, Jithin D., Henley, Jeremy M., Wilkinson, Kevin A.

“…Here, we detail a surface biotinylation technique used to label surface-expressed proteins in primary neuronal cultures. Surface proteins are labeled with…”
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GluK2 Q/R editing regulates kainate receptor signaling and long-term potentiation of AMPA receptors by Nair, Jithin D., Wilkinson, Kevin A., Yucel, Busra P., Mulle, Christophe, Vissel, Bryce, Mellor, Jack, Henley, Jeremy M.

“…Q/R editing of the kainate receptor (KAR) subunit GluK2 radically alters recombinant KAR properties, but the effects on endogenous KARs in vivo remain largely…”
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Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD by Nair, Jithin D., Braksator, Ellen, Yucel, Busra P., Fletcher-Jones, Alexandra, Seager, Richard, Mellor, Jack R., Bashir, Zafar I., Wilkinson, Kevin A., Henley, Jeremy M.

“…It is well established that long-term depression (LTD) can be initiated by either NMDA or mGluR activation. Here we report that sustained activation of…”
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Kainate receptors and synaptic plasticity by Nair, Jithin D., Wilkinson, Kevin A., Henley, Jeremy M., Mellor, Jack R.

“…Synaptic plasticity has classically been characterized to involve the NMDA and AMPA subtypes of glutamate receptors, with NMDA receptors providing the key…”
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Kainate and AMPA receptors in epilepsy: Cell biology, signalling pathways and possible crosstalk by Henley, Jeremy M., Nair, Jithin D., Seager, Richard, Yucel, Busra P., Woodhall, Gavin, Henley, Benjamin S., Talandyte, Karolina, Needs, Hope I., Wilkinson, Kevin A.

“…Epilepsy is caused when rhythmic neuronal network activity escapes normal control mechanisms, resulting in seizures. There is an extensive and growing body of…”
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Kainate Receptor Editing and Plasticity of Ampars by Nair, Jithin D

“…Kainate receptors (KARs) are hetero-tetrameric glutamate-gated ion channels. KARs are assemblies of five core subunits (GluK1-GluK5) with the combination GluK2…”
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