Search Results - "Naipal, A"

Tumor slice culture system to assess drug response of primary breast cancer by Naipal, Kishan A T, Verkaik, Nicole S, Sánchez, Humberto, van Deurzen, Carolien H M, den Bakker, Michael A, Hoeijmakers, Jan H J, Kanaar, Roland, Vreeswijk, Maaike P G, Jager, Agnes, van Gent, Dik C

“…The high incidence of breast cancer has sparked the development of novel targeted and personalized therapies. Personalization of cancer treatment requires…”
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Ex vivo assays to predict enhanced chemosensitization by hyperthermia in urothelial cancer of the bladder by van den Tempel, Nathalie, Naipal, Kishan A T, Raams, Anja, van Gent, Dik C, Franckena, Martine, Boormans, Joost L, Kanaar, Roland

“…Bladder cancer (urothelial carcinoma) is a common malignancy characterized by high recurrence rates and intense clinical follow-up, indicating the necessity…”
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Safe Stop IPI-NIVO trial: early discontinuation of nivolumab upon achieving a complete or partial response in patients with irresectable stage III or metastatic melanoma treated with first-line ipilimumab-nivolumab - study protocol by Janssen, J C, van Dijk, B, de Joode, K, Aarts, M J B, van den Berkmortel, F W P J, Blank, C U, Boers-Sonderen, M J, van den Eertwegh, A J M, de Groot, J W B, Jalving, M, de Jonge, M J A, Joosse, A, Kapiteijn, E, Kamphuis-Huismans, A M, Naipal, K A T, Piersma, D, Rikhof, B, Westgeest, H M, Vreugdenhil, G, Oomen-de Hoop, E, Mulder, E E A P, van der Veldt, Astrid A M

“…Patients with irresectable stage III or metastatic melanoma presenting with poor prognostic factors are usually treated with a combination of immune checkpoint…”
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Functional ex vivo assay to select homologous recombination-deficient breast tumors for PARP inhibitor treatment by Naipal, Kishan A T, Verkaik, Nicole S, Ameziane, Najim, van Deurzen, Carolien H M, Ter Brugge, Petra, Meijers, Matty, Sieuwerts, Anieta M, Martens, John W, O'Connor, Mark J, Vrieling, Harry, Hoeijmakers, Jan H J, Jonkers, Jos, Kanaar, Roland, de Winter, Johan P, Vreeswijk, Maaike P, Jager, Agnes, van Gent, Dik C

“…Poly(ADP-ribose) polymerase (PARP) inhibitors are promising targeted treatment options for hereditary breast tumors with a homologous recombination (HR)…”
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Attenuated XPC expression is not associated with impaired DNA repair in bladder cancer by Naipal, Kishan A T, Raams, Anja, Bruens, Serena T, Brandsma, Inger, Verkaik, Nicole S, Jaspers, Nicolaas G J, Hoeijmakers, Jan H J, van Leenders, Geert J L H, Pothof, Joris, Kanaar, Roland, Boormans, Joost, van Gent, Dik C

“…Bladder cancer has a high incidence with significant morbidity and mortality. Attenuated expression of the DNA damage response protein Xeroderma Pigmentosum…”
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Oral antibiotics lower mycophenolate mofetil drug exposure, possibly by interfering with the enterohepatic recirculation: A case series by Simoons, Mirjam, Naipal, Kishan A. T., Jong, Huib, Hoed, Caroline M., Winter, Brenda C. M., Mulder, Midas B.

“…Mycophenolate mofetil has an important role as immunosuppressive agent in solid organ transplant recipients. Exposure to the active mycophenolic acid (MPA) can…”
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Neoadjuvant Nivolumab and Ipilimumab in Resectable Stage III Melanoma by Blank, Christian U., Lucas, Minke W., Scolyer, Richard A., van de Wiel, Bart A., Menzies, Alexander M., Lopez-Yurda, Marta, Hoeijmakers, Lotte L., Saw, Robyn P.M., Lijnsvelt, Judith M., Maher, Nigel G., Pulleman, Saskia M., Gonzalez, Maria, Torres Acosta, Alejandro, van Houdt, Winan J., Lo, Serigne N., Kuijpers, Anke M.J., Spillane, Andrew, Klop, W. Martin C., Pennington, Thomas E., Zuur, Charlotte L., Shannon, Kerwin F., Seinstra, Beatrijs A., Rawson, Robert V., Haanen, John B.A.G., Ch’ng, Sydney, Naipal, Kishan A.T., Stretch, Jonathan, van Thienen, Johannes V., Rtshiladze, Michael A., Wilgenhof, Sofie, Kapoor, Rony, Meerveld-Eggink, Aafke, Grijpink-Ongering, Lindsay G., van Akkooi, Alexander C.J., Reijers, Irene L.M., Gyorki, David E., Grünhagen, Dirk J., Speetjens, Frank M., Vliek, Sonja B., Placzke, Joanna, Spain, Lavinia, Stassen, Robert C., Amini-Adle, Mona, Lebbé, Céleste, Faries, Mark B., Robert, Caroline, Ascierto, Paolo A., van Rijn, Rozemarijn, van den Berkmortel, Franchette W.P.J., Piersma, Djura, van der Westhuizen, Andre, Vreugdenhil, Gerard, Aarts, Maureen J.B., Stevense-den Boer, Marion A.M., Atkinson, Victoria, Khattak, Muhammad, Andrews, Miles C., van den Eertwegh, Alfons J.M., Boers-Sonderen, Marye J., Hospers, Geke A.P., Carlino, Matteo S., de Groot, Jan-Willem B., Kapiteijn, Ellen, Suijkerbuijk, Karijn P.M., Rutkowski, Piotr, Sandhu, Shahneen, van der Veldt, Astrid A.M., Long, Georgina V.

“…Among patients who received two 3-week cycles of neoadjuvant ipilimumab and nivolumab, the 12-month event-free survival was 83.7%, as compared with 57.2% among…”
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Functional Ex Vivo Assay Reveals Homologous Recombination Deficiency in Breast Cancer Beyond BRCA Gene Defects by Meijer, Titia G, Verkaik, Nicole S, Sieuwerts, Anieta M, van Riet, Job, Naipal, Kishan A T, van Deurzen, Carolien H M, den Bakker, Michael A, Sleddens, Hein F B M, Dubbink, Hendrikus-Jan, den Toom, T Dorine, Dinjens, Winand N M, Lips, Esther, Nederlof, Petra M, Smid, Marcel, van de Werken, Harmen J G, Kanaar, Roland, Martens, John W M, Jager, Agnes, van Gent, Dik C

“…Tumors of germline mutated carriers show homologous recombination (HR) deficiency (HRD), resulting in impaired DNA double-strand break (DSB) repair and high…”
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Targeted inhibition of metastatic melanoma through interference with Pin1-FOXM1 signaling by Kruiswijk, F, Hasenfuss, S C, Sivapatham, R, Baar, M P, Putavet, D, Naipal, K A T, van den Broek, N J F, Kruit, W, van der Spek, P J, van Gent, D C, Brenkman, A B, Campisi, J, Burgering, B M T, Hoeijmakers, J H J, de Keizer, P L J

“…Melanoma is the most lethal form of skin cancer and successful treatment of metastatic melanoma remains challenging. BRAF/MEK inhibitors only show a temporary…”
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Ex vivo tumor culture systems for functional drug testing and therapy response prediction by Meijer, Titia G, Naipal, Kishan At, Jager, Agnes, van Gent, Dik C

“…Optimal patient stratification is of utmost importance in the era of personalized medicine. Prediction of individual treatment responses by functional assays…”
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Genetic structure of IDDM1 : Two separate regions in the major histocompatibility complex contribute to susceptibility or protection by MOGHADDAM, P. H, DE KNIJF, P, ROEP, B. O, VAN DER AUWERA, B, NAIPAL, A, GORUS, F, SCHUIT, F, GIPHART, M. J

“…We analyzed 11 markers in the IDDM1 region in 120 IDDM patients and 83 healthy control subjects who were fully matched for the highest risk…”
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Normal HLA class I, II, and MICA gene distribution in uveal melanoma by Metzelaar-Blok, J A W, Hurks, H M H, Naipal, A, De Lange, P, Keunen, J E E, Claas, F H J, Doxiadis, I I N, Jager, M J

“…The molecules of the HLA class I and II molecules as well as the MHC class I chain-related gene A (MICA), a polymorphic and stress-induced cell surface…”
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World distribution of factor V Leiden mutation by de Maat, M P, Kluft, C, Jespersen, J, Gram, J

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Genetic structure of IDDM1: two separate regions in the major histocompatibility complex contribute to susceptibility or protection. Belgian Diabetes Registry by Hanifi Moghaddam, P, de Knijf, P, Roep, B O, Van der Auwera, B, Naipal, A, Gorus, F, Schuit, F, Giphart, M J

“…Genetic structure of IDDM1: two separate regions in the major histocompatibility complex contribute to susceptibility or protection. Belgian Diabetes Registry…”
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World distribution of factor V Leiden mutation by Fouéré, S, Guibal, F, Morel, P

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The influence of cytomegalovirus carrier status on lymphocyte subsets and natural immunity by GRATAMA, J. W, KARDOL, M, NAIPAL, A. M. I. H, SLATS, J, DEN OUDEN, A, STIJNEN, T, D'AMARO, J, THE, T. H, BRUNING, J. W

“…The influence of the cytomegalovirus (CMV) carrier status on peripheral lymphocyte subsets was studied in 70 healthy individuals. IgG-class antibodies against…”
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In vivo effects of combination treatment with recombinant interferon-gamma and -alpha in metastatic melanoma by Osanto, S, Jansen, R, Naipal, A M, Gratama, J W, van Leeuwen, A, Cleton, F J

“…The toxicity and therapeutic efficacy of the combination of recombinant interferon gamma (rIFN-gamma) and alpha (rIFN-alpha) was investigated in 15 patients…”
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Improved fusion technique. II. Stability and purity of hybrid clones by Westerwoudt, R J, Naipal, A M, Harrisson, C M

“…Optimal conditions are defined for hybridoma formation between mouse spleen cells and mouse myeloma cells. The results of using different numbers of spleen…”
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Effect of cytomegalovirus infection on T-lymphocytes after lymphocyte-depleted bone marrow transplantation by Gratama, J W, van Loon, A M, Oosterveer, M A, Naipal, A M, D'Amaro, J, de Witte, T J

“…The effect of cytomegalovirus (CMV) infection on the repopulation of the peripheral blood with T-lymphocytes was studied in recipients of lymphocyte-depleted…”
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Phenotypic study of CD4+ and CD8+ lymphocyte subsets in relation to cytomegalovirus carrier status and its correlate with pokeweed mitogen-induced B lymphocyte differentiation by Gratama, J W, Langelaar, R A, Oosterveer, M A, van der Linden, J A, den Ouden-Noordermeer, A, Naipal, A M, Visser, J W, de Gast, G C, Tanke, H J

“…A characteristic of active cytomegalovirus (CMV) infection is its suppressive effect on in vitro assays of immune function. The expression of CD11b by the Cd4+…”
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