Search Results - "Nain, Amrinder S"

Role of Suspended Fiber Structural Stiffness and Curvature on Single-Cell Migration, Nucleus Shape, and Focal-Adhesion-Cluster Length by Meehan, Sean, Nain, Amrinder S.

“…It has been shown that cellular migration, persistence, and associated cytoskeletal arrangement are highly dependent on substrate stiffness (modulus: N/m2 and…”
Get full text

Rules of contact inhibition of locomotion for cells on suspended nanofibers by Singh, Jugroop, Pagulayan, Aldwin, Camley, Brian A., Nain, Amrinder S.

“…Contact inhibition of locomotion (CIL), in which cells repolarize and move away from contact, is now established as a fundamental driving force in development,…”
Get full text

Nanonet Force Microscopy for Measuring Cell Forces by Sheets, Kevin, Wang, Ji, Zhao, Wei, Kapania, Rakesh, Nain, Amrinder S.

“…The influence of physical forces exerted by or felt by cells on cell shape, migration, and cytoskeleton arrangement is now widely acknowledged and hypothesized…”
Get full text

Crosshatch nanofiber networks of tunable interfiber spacing induce plasticity in cell migration and cytoskeletal response by Jana, Aniket, Nookaew, Intawat, Singh, Jugroop, Behkam, Bahareh, Franco, Aime T., Nain, Amrinder S.

“…ABSTRACT Biomechanical cues within tissue microenvironments are critical for maintaining homeostasis, and their disruption can contribute to malignant…”
Get full text

Shape-dependent cell migration and focal adhesion organization on suspended and aligned nanofiber scaffolds by Sheets, Kevin, Wunsch, Stephen, Ng, Colin, Nain, Amrinder S.

“…In the body, cells dynamically respond to chemical and mechanical cues from the extracellular matrix (ECM), yet precise mechanisms by which biophysical…”
Get full text

Bioprinting of growth factors onto aligned sub-micron fibrous scaffolds for simultaneous control of cell differentiation and alignment by Ker, Elmer D.F, Nain, Amrinder S, Weiss, Lee E, Wang, Ji, Suhan, Joseph, Amon, Cristina H, Campbell, Phil G

“…Abstract The capability to spatially control stem cell orientation and differentiation simultaneously using a combination of geometric cues that mimic…”
Get full text

Experimental and theoretical model for the origin of coiling of cellular protrusions around fibers by Sadhu, Raj Kumar, Hernandez-Padilla, Christian, Eisenbach, Yael Eshed, Penič, Samo, Zhang, Lixia, Vishwasrao, Harshad D., Behkam, Bahareh, Konstantopoulos, Konstantinos, Shroff, Hari, Iglič, Aleš, Peles, Elior, Nain, Amrinder S., Gov, Nir S.

“…Protrusions at the leading-edge of a cell play an important role in sensing the extracellular cues during cellular spreading and motility. Recent studies…”
Get full text

Cancer Protrusions on a Tightrope: Nanofiber Curvature Contrast Quantitates Single Protrusion Dynamics by Koons, Brian, Sharma, Puja, Ye, Zhou, Mukherjee, Apratim, Lee, Meng Horng, Wirtz, Denis, Behkam, Bahareh, Nain, Amrinder S

“…Cell migration is studied with the traditional focus on protrusion-driven cell body displacement, while less is known on morphodynamics of individual…”
Get full text

Author Correction: Experimental and theoretical model for the origin of coiling of cellular protrusions around fibers by Sadhu, Raj Kumar, Hernandez-Padilla, Christian, Eisenbach, Yael Eshed, Penič, Samo, Zhang, Lixia, Vishwasrao, Harshad D., Behkam, Bahareh, Konstantopoulos, Konstantinos, Shroff, Hari, Iglič, Aleš, Peles, Elior, Nain, Amrinder S., Gov, Nir S.

Get full text

Quantitative biophysical metrics for rapid evaluation of ovarian cancer metastatic potential by Mukherjee, Apratim, Zhang, Haonan, Ladner, Katherine, Brown, Megan, Urbanski, Jacob, Grieco, Joseph P, Kapania, Rakesh K, Lou, Emil, Behkam, Bahareh, Schmelz, Eva M, Nain, Amrinder S

“…Ovarian cancer is routinely diagnosed long after the disease has metastasized through the fibrous submesothelium. Despite extensive research in the field…”
Get full text

Bioenergetics underlying single-cell migration on aligned nanofiber scaffolds by Padhi, Abinash, Thomson, Alexander H, Perry, Justin B, Davis, Grace N, McMillan, Ryan P, Loesgen, Sandra, Kaweesa, Elizabeth N, Kapania, Rakesh, Nain, Amrinder S, Brown, David A

“…Cell migration is centrally involved in a myriad of physiological processes, including morphogenesis, wound healing, tissue repair, and metastatic growth. The…”
Get more information

Sculpting Rupture‐Free Nuclear Shapes in Fibrous Environments by Jana, Aniket, Tran, Avery, Gill, Amritpal, Kiepas, Alexander, Kapania, Rakesh K., Konstantopoulos, Konstantinos, Nain, Amrinder S.

“…Cytoskeleton‐mediated force transmission regulates nucleus morphology. How nuclei shaping occurs in fibrous in vivo environments remains poorly understood…”
Get full text

Cancer Cells Sense Fibers by Coiling on them in a Curvature-Dependent Manner by Mukherjee, Apratim, Behkam, Bahareh, Nain, Amrinder S.

“…Metastatic cancer cells sense the complex and heterogeneous fibrous extracellular matrix (ECM) by formation of protrusions, and our knowledge of how cells…”
Get full text

ECM in Differentiation: A Review of Matrix Structure, Composition and Mechanical Properties by Padhi, Abinash, Nain, Amrinder S.

“…Stem cell regenerative potential owing to the capacity to self-renew as well as differentiate into other cell types is a promising avenue in regenerative…”
Get full text

Force-exerting perpendicular lateral protrusions in fibroblastic cell contraction by Padhi, Abinash, Singh, Karanpreet, Franco-Barraza, Janusz, Marston, Daniel J., Cukierman, Edna, Hahn, Klaus M., Kapania, Rakesh K., Nain, Amrinder S.

“…Aligned extracellular matrix fibers enable fibroblasts to undergo myofibroblastic activation and achieve elongated shapes. Activated fibroblasts are able to…”
Get full text

Aligned Nanofiber Topography Directs the Tenogenic Differentiation of Mesenchymal Stem Cells by Popielarczyk, Tracee L, Nain, Amrinder S, Barrett, Jennifer G

“…Tendon is commonly injured, heals slowly and poorly, and often suffers re-injury after healing. This is due to failure of tenocytes to effectively remodel…”
Get full text

Suspended Micro/Nanofiber Hierarchical Biological Scaffolds Fabricated Using Non-Electrospinning STEP Technique by Wang, Ji, Nain, Amrinder S

“…Extracellular matrix (ECM) is a fibrous natural cell environment, possessing complicated micro- and nanoarchitectures, which provide extracellular signaling…”
Get full text

Contractility and migration: New directions in cancer stem cell migration by Kaur, Harsimran, Larson, Nathan Grega, Nain, Amrinder S.

Get full text

Direct and cell signaling-based, geometry-induced neuronal differentiation of neural stem cells by Bakhru, Sasha, Nain, Amrinder S, Highley, Christopher, Wang, Ji, Campbell, Phil, Amon, Cristina, Zappe, Stefan

“…Neural Stem Cells (NSCs) are multipotent precursors inhabiting the subventricular and hippocampal subgranular regions of the adult mammalian brain, able to…”
Get full text

Dendritic cell force-migration coupling on aligned fiber networks by Hernandez-Padilla, Christian, Joosten, Ben, Franco, Aime, Cambi, Alessandra, van den Dries, Koen, Nain, Amrinder S

“…Dendritic cells (DCs) are antigen-presenting cells that reside in peripheral tissues and are responsible for initiating adaptive immune responses. As…”
Get more information