Comparative expression analysis of human endogenous retrovirus elements in peripheral blood of children with specific language impairment

Specific language impairment (SLI) is a psychiatric condition with a complex etiology and a substantial genetic basis that affects children's verbal communication abilities. In this study, we examined the expression of five different human endogenous retrovirus elements (HERVs) in a cohort of 2...

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Bibliographic Details
Published in:	Balkan journal of medical genetics Vol. 22; no. 1; pp. 49 - 56
Main Authors:	Minchev, DS, Popov, NT, Naimov, SI, Minkov, IN, Vachev, TI
Format:	Journal Article
Language:	English
Published:	Sofia De Gruyter Poland 28-08-2019 Sciendo
Subjects:	blood-based quantitative reverse transcription-polymerase chain reaction (qrt-pcr) Children Etiology expression profiling Genomes human endogenous retrovirus elements (herv) Language Language disorders Mental disorders Nucleotide sequence Original Peripheral blood Polymerase chain reaction relative quantitation specific language impairment (sli)
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Summary:	Specific language impairment (SLI) is a psychiatric condition with a complex etiology and a substantial genetic basis that affects children's verbal communication abilities. In this study, we examined the expression of five different human endogenous retrovirus elements (HERVs) in a cohort of 25 children with SLI and 25 healthy children in the control group. Human endogenous retrovirus elements, a diverse group of repetitive DNA sequences, can potentially cause considerable genetic heterogeneity. They had been integrated in the genome of our ancestors throughout evolution and now consist of about 8.0% of the human genome. Several HERV loci are transcribed in various cell types. Their expression in peripheral blood and in the brain is altered in many neurological and psychiatric diseases. To date, HERV expression profiles have never been studied in patients with SLI. This study aimed to elucidate differentially regulated human endogenous retroelements in peripheral blood of children with SLI, in comparison with healthy controls, through quantitative reverse tran-scription-polymerase chain reaction (qRT-PCR) methodology. Our results show that two genes: HERV-K (HLM-2) gag and HERV-P env were expressed at lower levels in the blood samples from SLI children in comparison with those in the control group.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1311-0160 1311-0160 2199-5761
DOI:	10.2478/bjmg-2019-0014