Search Results - "Naika, Gajendra S."

Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation by Boudreau, Luc H., Duchez, Anne-Claire, Cloutier, Nathalie, Soulet, Denis, Martin, Nicolas, Bollinger, James, Paré, Alexandre, Rousseau, Matthieu, Naika, Gajendra S., Lévesque, Tania, Laflamme, Cynthia, Marcoux, Geneviève, Lambeau, Gérard, Farndale, Richard W., Pouliot, Marc, Hamzeh-Cognasse, Hind, Cognasse, Fabrice, Garraud, Olivier, Nigrovic, Peter A., Guderley, Helga, Lacroix, Steve, Thibault, Louis, Semple, John W., Gelb, Michael H., Boilard, Eric

“…Mitochondrial DNA (mtDNA) is a highly potent inflammatory trigger and is reportedly found outside the cells in blood in various pathologies. Platelets are…”
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Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A₂-IIA by Duchez, Anne-Claire, Boudreau, Luc H., Naika, Gajendra S., Bollinger, James, Belleannée, Clémence, Cloutier, Nathalie, Laffont, Benoit, Mendoza-Villarroel, Raifish E., Lévesque, Tania, Rollet-Labelle, Emmanuelle, Rousseau, Matthieu, Allaeys, Isabelle, Tremblay, Jacques J., Poubelle, Patrice E., Lambeau, Gérard, Pouliot, Marc, Provost, Patrick, Soulet, Denis, Gelb, Michael H., Boilard, Eric

“…Platelets are anucleated blood elements highly potent at generating extracellular vesicles (EVs) called microparticles (MPs). Whereas EVs are accepted as an…”
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Study of the role of cytosolic phospholipase A2 alpha in eicosanoid generation and thymocyte maturation in the thymus by Rousseau, Matthieu, Naika, Gajendra S, Perron, Jean, Jacques, Frederic, Gelb, Michael H, Boilard, Eric

“…The thymus is a primary lymphoid organ, home of maturation and selection of thymocytes for generation of functional T-cells. Multiple factors are involved…”
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Structural dynamics reveal isolate-specific differences at neutralization epitopes on HIV Env by Hodge, Edgar A., Naika, Gajendra S., Kephart, Sally M., Nguyen, Adam, Zhu, Richard, Benhaim, Mark A., Guo, Wenjin, Moore, John P., Hu, Shiu-Lok, Sanders, Rogier W., Lee, Kelly K.

“…The envelope glycoprotein (Env) is the sole target for neutralizing antibodies against HIV and the most rapidly evolving, variable part of the virus…”
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Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen by Nolin, James D, Lai, Ying, Ogden, Herbert Luke, Manicone, Anne M, Murphy, Ryan C, An, Dowon, Frevert, Charles W, Ghomashchi, Farideh, Naika, Gajendra S, Gelb, Michael H, Gauvreau, Gail M, Piliponsky, Adrian M, Altemeier, William A, Hallstrand, Teal S

“…Phospholipase A2 (PLA2) enzymes regulate the formation of eicosanoids and lysophospholipids that contribute to allergic airway inflammation. Secreted PLA2…”
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Characterization of functional intermediates of endoglucanase from Aspergillus aculeatus during urea and guanidine hydrochloride unfolding by Naika, Gajendra S., Tiku, Purnima Kaul

“…Low concentrations of urea and GuHCl (2 M) enhanced the activity of endoglucanase (EC 3.1.2.4) from Aspergillus aculeatus by 2.3- and 1.9-fold, respectively…”
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Respective contribution of cytosolic phospholipase A2α and secreted phospholipase A2 IIA to inflammation and eicosanoid production in arthritis by Duchez, Anne-Claire, Boudreau, Luc H., Naika, Gajendra S., Rousseau, Matthieu, Cloutier, Nathalie, Levesque, Tania, Gelb, Michael H., Boilard, Eric

“…•Cytosolic and secreted IIA phospholipase A2 are suggested implicated in arthritis.•No study ever verified their respective contribution to arthritis.•Mice…”
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Identification of Epithelial Phospholipase A2 Receptor 1 as a Potential Target in Asthma by Nolin, James D, Ogden, H Luke, Lai, Ying, Altemeier, William A, Frevert, Charles W, Bollinger, James G, Naika, Gajendra S, Kicic, Anthony, Stick, Stephen M, Lambeau, Gerard, HendersonJr, William R, Gelb, Michael H, Hallstrand, Teal S

“…Secreted phospholipase A^sub 2^s (sPLA^sub 2^s) regulate eicosanoid formation and have been implicated in asthma. Although sPLA^sub 2^s function as enzymes,…”
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Influence of Ethylenediaminetetraacetic Acid (EDTA) on the Structural Stability of Endoglucanase from Aspergillus aculeatus by Naika, Gajendra S, Tiku, Purnima Kaul

“…The effect of the chelating agent ethylenediaminetetraacetic acid (EDTA) on the structure and function of endoglucanase is studied. In the presence of 2 mM…”
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In vitro anti-Plasmodium falciparum properties of the full set of human secreted phospholipases A2 by Guillaume, Carole, Payré, Christine, Jemel, Ikram, Jeammet, Louise, Bezzine, Sofiane, Naika, Gajendra S, Bollinger, James, Grellier, Philippe, Gelb, Michael H, Schrével, Joseph, Lambeau, Gérard, Deregnaucourt, Christiane

“…We have previously shown that secreted phospholipases A2 (sPLA2s) from animal venoms inhibit the in vitro development of Plasmodium falciparum, the agent of…”
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Interfacial Kinetic and Binding Properties of Mammalian Group IVB Phospholipase A2 (cPLA2β) and Comparison with the Other cPLA2 Isoforms by Ghomashchi, Farideh, Naika, Gajendra S., Bollinger, James G., Aloulou, Ahmed, Lehr, Matthias, Leslie, Christina C., Gelb, Michael H.

“…The cytosolic (group IV) phospholipase A2 (cPLA2s) family contains six members. We have prepared recombinant proteins for human α, mouse β, human γ, human δ,…”
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Identification of Epithelial Phospholipase A 2 Receptor 1 as a Potential Target in Asthma by Nolin, James D, Ogden, H Luke, Lai, Ying, Altemeier, William A, Frevert, Charles W, Bollinger, James G, Naika, Gajendra S, Kicic, Anthony, Stick, Stephen M, Lambeau, Gerard, Henderson, Jr, William R, Gelb, Michael H, Hallstrand, Teal S

“…Secreted phospholipase A s (sPLA s) regulate eicosanoid formation and have been implicated in asthma. Although sPLA s function as enzymes, some of the sPLA s…”
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In Vitro Anti-Plasmodium falciparum Properties of the Full Set of Human Secreted Phospholipases A 2 by Guillaume, Carole, Payré, Christine, Jemel, Ikram, Jeammet, Louise, Bezzine, Sofiane, Naika, Gajendra S., Bollinger, James, Grellier, Philippe, Gelb, Michael H., Schrével, Joseph, Lambeau, Gérard, Deregnaucourt, Christiane

“…ABSTRACT We have previously shown that secreted phospholipases A 2 (sPLA 2 s) from animal venoms inhibit the in vitro development of Plasmodium falciparum ,…”
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Effect of Cosolvents on the Structural Stability of Endoglucanase from Aspergillus aculeatus by Naika, Gajendra S, Prakash, Vishweshwaraiah, Tiku, Purnima Kaul

“…The effects of cosolvents such as sucrose, glycerol, and sorbitol on endoglucanase have been studied by activity, circular dichroic spectroscopy, fluorescence,…”
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LC/ESI-MS/MS detection of FAs by charge reversal derivatization with more than four orders of magnitude improvement in sensitivity[S] by Bollinger, James G., Rohan, Gajendra, Sadilek, Martin, Gelb, Michael H.

“…Quantitative analysis of fatty acids (FAs) is an important area of analytical biochemistry. Ultra high sensitivity FA analysis usually is done with gas…”
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Respective contribution of cytosolic phospholipase A2α and secreted phospholipase A 2 IIA to inflammation and eicosanoid production in arthritis by Duchez, Anne-Claire, Boudreau, Luc H, Naika, Gajendra S, Rousseau, Matthieu, Cloutier, Nathalie, Levesque, Tania, Gelb, Michael H, Boilard, Eric

“…Phospholipase A s (PLA ) play a key role in generation of eicosanoids. Cytosolic PLA α (cPLA α) is constitutively expressed in most cells, whereas IIA secreted…”
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An HIV-1 broadly neutralizing antibody overcomes structural and dynamic variation through highly focused epitope targeting by Hodge, Edgar A, Chatterjee, Ananya, Chen, Chengbo, Naika, Gajendra S, Laohajaratsang, Mint, Mangala Prasad, Vidya, Lee, Kelly K

“…The existence of broadly cross-reactive antibodies that can neutralize diverse HIV-1 isolates (bnAbs) has been appreciated for more than a decade. Many…”
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Study of the Role of Cytosolic Phospholipase A.sub.2 Alpha in Eicosanoid Generation and Thymocyte Maturation in the Thymus by Rousseau, Matthieu, Naika, Gajendra S, Perron, Jean, Jacques, Frederic, Gelb, Michael H, Boilard, Eric

“…The thymus is a primary lymphoid organ, home of maturation and selection of thymocytes for generation of functional T-cells. Multiple factors are involved…”
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Abstract 6376: Discovery and preclinical characterization of dual antagonist antibodies targeting both LILRB1 and LILRB2 that enhance innate and adaptive anti-cancer immune responses by Zuck, Meghan, Bouchlaka, Myriam, Dinh, Huyen, Green, Kevin, Zapata, Francisco, Chandrasekaran, Ramya, Pisarenko, Tatyana, Loh, Lauren, Naika, Gajendra S., Sylvestre, Meilyn, Heit, Jacob, Fox, Raymond, Whitman, Darbie, Graddis, Tom, Puri, Kamal D., Probst, Peter

“…Abstract Background: One cause for the failure of checkpoint inhibitors is the immunosuppressive nature of the tumor microenvironment. LILRB1 (ILT2) and LILRB2…”
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Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A 2 -IIA by Duchez, Anne-Claire, Boudreau, Luc H., Naika, Gajendra S., Bollinger, James, Belleannée, Clémence, Cloutier, Nathalie, Laffont, Benoit, Mendoza-Villarroel, Raifish E., Lévesque, Tania, Rollet-Labelle, Emmanuelle, Rousseau, Matthieu, Allaeys, Isabelle, Tremblay, Jacques J., Poubelle, Patrice E., Lambeau, Gérard, Pouliot, Marc, Provost, Patrick, Soulet, Denis, Gelb, Michael H., Boilard, Eric

“…Significance On activation, blood platelets package components from their cytoplasm into microparticles (MPs), tiny vesicles released by cytoplasmic membrane…”
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