Search Results - "Naik, Siddhi D."

4′-Selenonucleosides as Next-Generation Nucleosides by Sahu, Pramod K., Naik, Siddhi D., Yu, Jinha, Jeong, Lak Shin

“…Modified nucleosides continue to hold their position as one of the most fruitful classes of therapeutic agents in drug discovery. One fairly recent…”
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Structure-Activity Relationships of Acyclic Selenopurine Nucleosides as Antiviral Agents by Sahu, Pramod K, Umme, Tamima, Yu, Jinha, Kim, Gyudong, Qu, Shuhao, Naik, Siddhi D, Jeong, Lak Shin

“…A series of acyclic selenopurine nucleosides - and - were synthesized based on the bioisosteric rationale between oxygen and selenium, and then evaluated for…”
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Synthesis and Anti-HIV Activity of 5′-Homo-2′,3′-dideoxy-2′,3′-didehydro-4′-selenonucleosides (5′-Homo-4′-Se-d4 Ns) by Qu, Shuhao, Kim, Gyudong, Yu, Jinha, Sahu, Pramod K., Choi, Yoojin, Naik, Siddhi D., Jeong, Lak Shin

“…On the hypothesis that one carbon homologation of 4′‐selenonucleosides might relieve the steric repulsion between cellular kinases and bulky selenium,…”
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Stereochemical influence of 4ʹ-methyl substitutions on truncated 4ʹ-thioadenosine derivatives: Impact on A3 adenosine receptor binding and antagonism by Kim, Minjae, Naik, Siddhi D., Jarhad, Dnyandev B., Aswar, Vikas R., Tripathi, Sushil Kumar, Aslam, Muhammad Arif, Huh, Joo Young, Jeong, Lak Shin

“…[Display omitted] •We synthesized truncated 4ʹ-thioadenosine derivatives with 4ʹ-methyl groups.•The hA3AR binding affinity follows:…”
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Design, Synthesis, and Molecular Docking Analysis of Fluorinated MLN4924 Derivatives as Antiviral Agents by Sung, Kisu, Hyeon, Seokhwan, Kim, Minjae, Sahu, Pramod K., Naik, Siddhi D., Aswar, Vikas R., Tripathi, Sushil K., Chang, Tong‐Shin, Ahn, Jin‐Hyun, Yu, Jinha, Jeong, Lak Shin

“…MLN4924 is known for its potential in cancer treatment and antiviral activity as a NEDD8‐activating enzyme (NAE) inhibitor. We designed and synthesized…”
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Exploring C 2 and N 6 Substituent Effects on Truncated 4′‐Thioadenosine Derivatives as Dual A 2A and A 3 Adenosine Receptor Ligands by Naik, Siddhi D., Kim, Minjae, Choi, Jiyoung, Kim, Gibae, Woo Kim, Seung, Aswar, Vikas R., Tripathi, Sushil K., Gaikwad, Vidyasagar, Yu, Jinha, Shin Jeong, Lak

“…Based on high binding affinity of truncated 2‐hexynyl‐4′‐thioadenosine ( 3 a ) at both A 2A adenosine receptor (AR) and A 3 AR, we explored structure‐activity…”
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Exploring C2 and N6 Substituent Effects on Truncated 4'-Thioadenosine Derivatives as Dual A2A and A3 Adenosine Receptor Ligands by Naik, Siddhi D, Kim, Minjae, Choi, Jiyoung, Kim, Gibae, Kim, Seung Woo, Aswar, Vikas R, Tripathi, Sushil K, Gaikwad, Vidyasagar, Yu, Jinha, Jeong, Lak Shin

“…Based on high binding affinity of truncated 2-hexynyl-4'-thioadenosine (3a) at both A2A adenosine receptor (AR) and A3 AR, we explored structure-activity…”
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Stereochemical influence of 4'-methyl substitutions on truncated 4'-thioadenosine derivatives: Impact on A 3 adenosine receptor binding and antagonism by Kim, Minjae, Naik, Siddhi D, Jarhad, Dnyandev B, Aswar, Vikas R, Tripathi, Sushil Kumar, Aslam, Muhammad Arif, Huh, Joo Young, Jeong, Lak Shin

“…Herein, we investigated the stereochemical effects of 4'-methyl substitution on A adenosine receptor (A AR) ligands by synthesizing and evaluating a series of…”
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Synthesis and Anti-HIV Activity of 5'-Homo-2',3'-dideoxy-2',3'-dide hydro-4'-selenonucleosides (5'-Homo-4'-Se-d4Ns) by Qu, Shuhao, Kim, Gyudong, Yu, Jinha, Sahu, Pramod K, Choi, Yoojin, Naik, Siddhi D, Jeong, Lak Shin

“…On the hypothesis that one carbon homologation of 4'-selenonucleosides might relieve the steric repulsion between cellular kinases and bulky selenium,…”
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