Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Third International Conference on 3Rs Research and Progress, Vishakhapatnam, 2022

Animal experimentation has been integral to drug discovery and development and safety assessment for many years, since it provides insights into the mechanisms of drug efficacy and toxicity (e.g. pharmacology, pharmacokinetics and pharmacodynamics). However, due to species differences in physiology,...

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Bibliographic Details
Published in:	Alternatives to laboratory animals Vol. 51; no. 4; pp. 263 - 288
Main Authors:	Naik, Nikita Narayan, Vadloori, Bharadwaja, Poosala, Suresh, Srivastava, Pratima, Coecke, Sandra, Smith, Adrian, Akhtar, Aysha, Roper, Clive, Radhakrishnan, Sridhar, Bhyravbhatla, Balaji, Damle, Madhujit, Pulla, Venkat Koushik, Hackethal, Johannes, Horland, Reyk, Li, Albert P., Pati, Falguni, Singh, Manu Smriti, Occhetta, Paola, Bisht, Rohit, Dandekar, Prajakta, Bhagavatula, Krishna, Pajkrt, Dasja, Johnson, Michael, Weber, Tilo, Huang, John, Hysenaj, Lisiena, Mallar, Banerjee, Ramray, Bhat, Dixit, Santosh, Joshi, Shreekanth, Kulkarni, Mandar
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-07-2023
Subjects:	Animal Experimentation Animal Testing Alternatives Animals Drug Discovery Humans India Models, Animal India new approach methodologies animal models microphysiological system animal-free organoid spheroid tissue microenvironment organs-on-chips Three Rs 3Rs drug discovery organ-on-a-chip NAMs replacement
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Summary:	Animal experimentation has been integral to drug discovery and development and safety assessment for many years, since it provides insights into the mechanisms of drug efficacy and toxicity (e.g. pharmacology, pharmacokinetics and pharmacodynamics). However, due to species differences in physiology, metabolism and sensitivity to drugs, the animal models can often fail to replicate the effects of drugs and chemicals in human patients, workers and consumers. Researchers across the globe are increasingly applying the Three Rs principles by employing innovative methods in research and testing. The Three Rs concept focuses on: the replacement of animal models (e.g. with in vitro and in silico models or human studies), on the reduction of the number of animals required to achieve research objectives, and on the refinement of existing experimental practices (e.g. eliminating distress and enhancing animal wellbeing). For the last two years, Oncoseek Bio-Acasta Health, a 3-D cell culture-based cutting-edge translational biotechnology company, has organised an annual International Conference on 3Rs Research and Progress. This series of global conferences aims to bring together researchers with diverse expertise and interests, and provides a platform where they can share and discuss their research to promote practices according to the Three Rs principles. In November 2022, the 3rd international conference, Advances in Animal Models and Cutting-Edge Research in Alternatives, took place at the GITAM University in Vishakhapatnam (AP, India) in a hybrid format (i.e. online and in-person). These conference proceedings provide details of the presentations, which were categorised under five different topic sessions. It also describes a special interactive session on in silico strategies for preclinical research in oncology, which was held at the end of the first day.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0261-1929 2632-3559
DOI:	10.1177/02611929231180428