Search Results - "Naiel, Safaa"

Endoplasmic reticulum stress inhibition blunts the development of essential hypertension in the spontaneously hypertensive rat by Naiel, Safaa, Carlisle, Rachel E, Lu, Chao, Tat, Victor, Dickhout, Jeffrey G

“…Essential hypertension is the leading cause of premature death worldwide. However, hypertension's cause remains uncertain. endoplasmic reticulum (ER) stress…”
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Activin A and Cell-Surface GRP78 Are Novel Targetable RhoA Activators for Diabetic Kidney Disease by Soomro, Asfia, Trink, Jackie, O'Neil, Kian, Li, Renzhong, Naiel, Safaa, Gao, Bo, Ask, Kjetil, Krepinsky, Joan C

“…Diabetic kidney disease (DKD) is the leading cause of kidney failure. RhoA/Rho-associated protein kinase (ROCK) signaling is a recognized mediator of its…”
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Alterations to the middle cerebral artery of the hypertensive-arthritic rat model potentiates intracerebral hemorrhage by Randell, Amy, Chokshi, Killol, Kane, Brittany, Chang, Hilary, Naiel, Safaa, Dickhout, Jeffrey G, Daneshtalab, Noriko

“…We have recently created an age-dependent hypertensive-mono-arthritic animal model from the stroke-resistant spontaneously hypertensive rat to model…”
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Monocyte and macrophage derived myofibroblasts: Is it fate? A review of the current evidence by Vierhout, Megan, Ayoub, Anmar, Naiel, Safaa, Yazdanshenas, Parichehr, Revill, Spencer D., Reihani, Amir, Dvorkin‐Gheva, Anna, Shi, Wei, Ask, Kjetil

“…Since the discovery of the myofibroblast over 50 years ago, much has been learned about its role in wound healing and fibrosis. Its origin, however, remains…”
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Protein Misfolding and Endoplasmic Reticulum Stress in Chronic Lung Disease: Will Cell-Specific Targeting Be the Key to the Cure? by Naiel, Safaa, Tat, Victor, Padwal, Manreet, Vierhout, Megan, Mekhael, Olivia, Yousof, Tamana, Ayoub, Anmar, Abed, Soumeya, Dvorkin-Gheva, Anna, Ask, Kjetil

“…Chronic lung disease accounts for a significant global burden with respect to death, disability, and health-care costs. Due to the heterogeneous nature and…”
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Cell-specific drug targeting in the lung by Abed, Soumeya, Turner, Rebecca, Serniuck, Nickolas, Tat, Victor, Naiel, Safaa, Hayat, Aaron, Mekhael, Olivia, Vierhout, Megan, Ask, Kjetil, Rullo, Anthony F.

“…[Display omitted] Non-targeted drug delivery systems have several limitations including the decreased bioavailability of the drug, poor stability and rapid…”
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Therapeutic strategies targeting pro-fibrotic macrophages in interstitial lung disease by Isshiki, Takuma, Vierhout, Megan, Naiel, Safaa, Ali, Pareesa, Yazdanshenas, Parichehr, Kumaran, Vaishnavi, Yang, Zi, Dvorkin-Gheva, Anna, Rullo, Anthony F., Kolb, Martin R.J., Ask, Kjetil

“…[Display omitted] Idiopathic pulmonary fibrosis (IPF) is the representative phenotype of interstitial lung disease where severe scarring develops in the lung…”
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Therapeutic strategies to target connective tissue growth factor in fibrotic lung diseases by Isshiki, Takuma, Naiel, Safaa, Vierhout, Megan, Otsubo, Kohei, Ali, Pareesa, Tsubouchi, Kazuya, Yazdanshenas, Parichehr, Kumaran, Vaishnavi, Dvorkin-Gheva, Anna, Kolb, Martin R J, Ask, Kjetil

“…The treatment of interstitial lung diseases, including idiopathic pulmonary fibrosis (IPF), remains challenging as current available antifibrotic agents are…”
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Protein Misfolding and Endoplasmic Reticulum Stress in Chronic Lung Disease by Naiel, Safaa, Tat, Victor, Padwal, Manreet, Vierhout, Megan, Mekhael, Olivia, Yousof, Tamana, Ayoub, Anmar, Abed, Soumeya, Dvorkin-Gheva, Anna, Ask, Kjetil

“…Chronic lung disease accounts for a significant global burden with respect to death, disability, and health-care costs. Due to the heterogeneous nature and…”
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FK506-Binding Protein 13 Expression Is Upregulated in Interstitial Lung Disease and Correlated with Clinical Severity. A Potentially Protective Role by Tat, Victor, Ayaub, Ehab A, Ayoub, Anmar, Vierhout, Megan, Naiel, Safaa, Padwal, Manreet K, Abed, Soumeya, Mekhael, Olivia, Tandon, Karun, Revill, Spencer D, Yousof, Tamana, Bellaye, Pierre-Simon, Kolb, Philipp S, Dvorkin-Gheva, Anna, Naqvi, Asghar, Cutz, Jean-Claude, Hambly, Nathan, Kato, Jiro, Vaughan, Martha, Moss, Joel, Kolb, Martin R J, Ask, Kjetil

“…Pulmonary fibrosis is a progressive lung disease characterized by myofibroblast accumulation and excessive extracellular matrix deposition. We sought to…”
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Inhalation: A means to explore and optimize nintedanib's pharmacokinetic/pharmacodynamic relationship by Epstein-Shochet, Gali, Pham, Stephen, Beck, Steven, Naiel, Safaa, Mekhael, Olivia, Revill, Spencer, Hayat, Aaron, Vierhout, Megan, Bardestein-Wald, Becky, Shitrit, David, Ask, Kjetil, Montgomery, A. Bruce, Kolb, Martin R., Surber, Mark W.

“…Oral nintedanib is marketed for the treatment of idiopathic pulmonary fibrosis (IPF). While effective slowing fibrosis progression, as an oral medicine…”
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