Search Results - "Naidoo, Kalnisha"

Relevance of Spatial Heterogeneity of Immune Infiltration for Predicting Risk of Recurrence After Endocrine Therapy of ER+ Breast Cancer by Heindl, Andreas, Sestak, Ivana, Naidoo, Kalnisha, Cuzick, Jack, Dowsett, Mitchell, Yuan, Yinyin

“…Despite increasing evidence supporting the clinical utility of immune infiltration in the estrogen receptor-negative (ER-) subtype, the prognostic value of…”
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Evaluation of CDK12 Protein Expression as a Potential Novel Biomarker for DNA Damage Response-Targeted Therapies in Breast Cancer by Naidoo, Kalnisha, Wai, Patty T, Maguire, Sarah L, Daley, Frances, Haider, Syed, Kriplani, Divya, Campbell, James, Mirza, Hasan, Grigoriadis, Anita, Tutt, Andrew, Moseley, Paul M, Abdel-Fatah, Tarek M A, Chan, Stephen Y T, Madhusudan, Srinivasan, Rhaka, Emad A, Ellis, Ian O, Lord, Christopher J, Yuan, Yinyin, Green, Andrew R, Natrajan, Rachael

“…Disruption of Cyclin-Dependent Kinase 12 ( ) is known to lead to defects in DNA repair and sensitivity to platinum salts and PARP1/2 inhibitors. However, has…”
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Micro- and macro-metastasis in the axillary lymph node: A review by Naidoo, Kalnisha, Pinder, Sarah E

“…Abstract Pathologists typically examine the sentinel lymph nodes excised from patients with invasive breast cancer more thoroughly than they have historically…”
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Proteome of formalin-fixed paraffin-embedded pancreatic ductal adenocarcinoma and lymph node metastases by Naidoo, Kalnisha, Jones, Richard, Dmitrovic, Branko, Wijesuriya, Nilukshi, Kocher, Hemant, Hart, Ian R, Crnogorac-Jurcevic, Tatjana

“…Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer‐related death, largely due to metastatic disease. To better understand PDAC metastatic…”
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Proteomics of REPLICANT perfusate detects changes in the metastatic lymph node microenvironment by Stevenson, Julia, Barrow-McGee, Rachel, Yu, Lu, Paul, Angela, Mansfield, David, Owen, Julie, Woodman, Natalie, Natrajan, Rachael, Haider, Syed, Gillett, Cheryl, Tutt, Andrew, Pinder, Sarah E., Choudary, Jyoti, Naidoo, Kalnisha

“…In breast cancer (BC), detecting low volumes of axillary lymph node (ALN) metastasis pre-operatively is difficult and novel biomarkers are needed. We recently…”
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Histological scoring of immune and stromal features in breast and axillary lymph nodes is prognostic for distant metastasis in lymph node‐positive breast cancers by Grigoriadis, Anita, Gazinska, Patrycja, Pai, Trupti, Irhsad, Sheeba, Wu, Yin, Millis, Rosemary, Naidoo, Kalnisha, Owen, Julie, Gillett, Cheryl E, Tutt, Andrew, Coolen, Anthonius CC, Pinder, Sarah E

“…The prognostic importance of lymph node (LN) status and tumour‐infiltrating lymphocytes (TILs), is well established, particularly TILs in triple negative…”
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A simple human co-culture model of lymphatic invasion by Naidoo, Kalnisha

“…True lymphovascular invasion in most carcinomas adversely affects survival, but human models of lymphatic invasion are lacking. Herein is discussed one such…”
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Automated Classification of Breast Cancer Stroma Maturity From Histological Images by Reis, Sara, Gazinska, Patrycja, Hipwell, John H., Mertzanidou, Thomy, Naidoo, Kalnisha, Williams, Norman, Pinder, Sarah, Hawkes, David J.

“…Objective: The tumor microenvironment plays a crucial role in regulating tumor progression by a number of different mechanisms, in particular, the remodeling…”
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An audit of residual cancer burden reproducibility in a UK context by Naidoo, Kalnisha, Parham, David M, Pinder, Sarah E

“…Aims The residual cancer burden score (RCB) is currently the preferred quantification tool for assessing residual disease following neoadjuvant chemotherapy…”
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Dynamic Changes in the NK-, Neutrophil-, and B-cell Immunophenotypes Relevant in High Metastatic Risk Post Neoadjuvant Chemotherapy-Resistant Early Breast Cancers by Gazinska, Patrycja, Milton, Charlotte, Iacovacci, Jacopo, Ward, Joseph, Buus, Richard, Alaguthurai, Thanussuyah, Graham, Rosalind, Akarca, Ayse, Lips, Esther, Naidoo, Kalnisha, Wesseling, Jelle, Marafioti, Teresa, Cheang, Maggie, Gillett, Cheryl, Wu, Yin, Khan, Aadil, Melcher, Alan, Salgado, Roberto, Dowsett, Mitch, Tutt, Andrew, Roxanis, Ioannis, Haider, Syed, Irshad, Sheeba

“…To identify potential immune targets in post-neoadjuvant chemotherapy (NAC)-resistant triple-negative breast cancer (TNBC) and ER+HER2- breast cancer disease…”
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Immunohistochemistry for Triple-Negative Breast Cancer by Naidoo, Kalnisha, Pinder, Sarah E

“…Triple-negative breast cancers are a heterogeneous group of tumors that are, as yet, not entirely understood. Although triple-negative carcinomas are strictly…”
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Rational treatment of chemotherapy-induced peripheral neuropathy with capsaicin 8% patch: from pain relief towards disease modification by Anand, Praveen, Elsafa, Enas, Privitera, Rosario, Naidoo, Kalnisha, Yiangou, Yiangos, Donatien, Philippe, Gabra, Hani, Wasan, Harpreet, Kenny, Laura, Rahemtulla, Amin, Misra, Peter

“…Chemotherapy-induced peripheral neuropathy (CIPN) with associated chronic pain is a common and disabling condition. Current treatments for neuropathic pain in…”
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Assessment of the Molecular Heterogeneity of E-Cadherin Expression in Invasive Lobular Breast Cancer by Alexander, John, Mariani, Odette, Meaudre, Celine, Fuhrmann, Laetitia, Xiao, Hui, Naidoo, Kalnisha, Gillespie, Andrea, Roxanis, Ioannis, Vincent-Salomon, Anne, Haider, Syed, Natrajan, Rachael

“…Mutations and loss of E-cadherin protein expression define the vast majority of invasive lobular carcinomas. In a subset of these cases, the heterogeneous…”
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3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer by Peck, Barrie, Bland, Philip, Mavrommati, Ioanna, Muirhead, Gareth, Cottom, Hannah, Wai, Patty T, Maguire, Sarah L, Barker, Holly E, Morrison, Eamonn, Kriplani, Divya, Yu, Lu, Gibson, Amy, Falgari, Giulia, Brennan, Keith, Farnie, Gillian, Buus, Richard, Marlow, Rebecca, Novo, Daniela, Knight, Eleanor, Guppy, Naomi, Kolarevic, Daniela, Susnjar, Snezana, Milijic, Natasa Medic, Naidoo, Kalnisha, Gazinska, Patrycja, Roxanis, Ioannis, Pancholi, Sunil, Martin, Lesley-Ann, Holgersen, Erle M, Cheang, Maggie C U, Noor, Farzana, Postel-Vinay, Sophie, Quinn, Gerard, McDade, Simon, Krasny, Lukas, Huang, Paul, Daley, Frances, Wallberg, Fredrik, Choudhary, Jyoti S, Haider, Syed, Tutt, Andrew N, Natrajan, Rachael

“…Triple-negative breast cancers (TNBC) are resistant to standard-of-care chemotherapy and lack known targetable driver gene alterations. Identification of novel…”
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Real‐time ex vivo perfusion of human lymph nodes invaded by cancer (REPLICANT): a feasibility study by Barrow‐McGee, Rachel, Procter, Julia, Owen, Julie, Woodman, Natalie, Lombardelli, Cristina, Kothari, Ashutosh, Kovacs, Tibor, Douek, Michael, George, Simi, Barry, Peter A, Ramsey, Kelvin, Gibson, Amy, Buus, Richard, Holgersen, Erle, Natrajan, Rachael, Haider, Syed, Shattock, Michael J, Gillett, Cheryl, Tutt, Andrew NJ, Pinder, Sarah E, Naidoo, Kalnisha

“…Understanding how breast cancer (BC) grows in axillary lymph nodes (ALNs), and refining how therapies might halt that process, is clinically important…”
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Abstract 788: Modeling tumor microenvironmental heterogeneity identifies CREBBP as a novel tumor suppressor in breast cancer by Peck, Barrie, Bland, Philip J., Wai, Patty T., Cottom, Hannah, Maguire, Sarah L., Morrison, Eamonn, Barker, Holly E., Kriplani, Divya, Marlow, Rebecca, Naidoo, Kalnisha, Muirhead, Gareth, Haider, Syed, Daley, Frances, Wallberg, Frederik, Tutt, Andrew N., Natrajan, Rachael C.

“…Abstract Solid tumors display significant histological, genetic and micro-environmental intra-tumor heterogeneity that can change substantially over the course…”
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Optimised ARID1A immunohistochemistry is an accurate predictor of ARID1A mutational status in gynaecological cancers by Khalique, Saira, Naidoo, Kalnisha, Attygalle, Ayoma D, Kriplani, Divya, Daley, Frances, Lowe, Anne, Campbell, James, Jones, Thomas, Hubank, Michael, Fenwick, Kerry, Matthews, Nicholas, Rust, Alistair G, Lord, Christopher J, Banerjee, Susana, Natrajan, Rachael

“…ARID1A is a tumour suppressor gene that is frequently mutated in clear cell and endometrioid carcinomas of the ovary and endometrium and is an important…”
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Abstract A28: Evaluation of CDK12 protein expression as a novel biomarker for PARP1/2 inhibitor sensitivity in breast cancer by Naidoo, Kalnisha, Wai, Patty, Maguire, Sarah, Daley, Frances, Yuan, Yinyin, Rakha, Emad A., Ellis, Ian O., Lord, Christopher J., Green, Andrew R., Natrajan, Rachael C.

“…Abstract The CycK/CDK12 complex is known to protect normal cells from genomic instability by regulating the DNA damage response (DDR) and has been postulated…”
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Accuracy of classification of invasive lobular carcinoma on needle core biopsy of the breast by Naidoo, Kalnisha, Beardsley, Brooke, Carder, Pauline J, Deb, Rahul, Fish, David, Girling, Anne, Hales, Sally, Howe, Miles, Wastall, Laura M, Lane, Sally, Lee, Andrew H S, Philippidou, Marianna, Quinn, Cecily, Stephenson, Tim, Pinder, Sarah E

“…Although the UK National Institute for Health and Care Excellence guidelines recommend that in patients with biopsy-proven invasive lobular carcinoma (ILC),…”
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Molecular mechanisms of lymphatic invasion in pancreatic ductal adenocarcinoma by Naidoo, Kalnisha

“…Pancreatic Ductal Adenocarcinoma (PDAC) is one of the five leading causes of cancer-related deaths in the West, and this, largely, is due to metastatic…”
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