Crescentic postinfectious glomerulonephritis in an adult patient with juvenile nasopharyngeal angiofibroma

Crescentic glomerulonephritis is usually associated with an acute nephritic syndrome with rapidly declining renal function. Postinfectious cases usually have a higher possibility of recovery. Juvenile nasopharyngeal angiofibroma (JNA) is a rare, locally aggressive tumour affecting mostly young men....

Full description

Saved in:

Bibliographic Details
Published in:	BMJ case reports Vol. 14; no. 4; p. e242785
Main Authors:	Manalili, Sheryll Anne, So, Paolo Nikolai, Naidas, Maria Ana Louise, Villanueva, Anthony Russell
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group LTD 23-04-2021 BMJ Publishing Group
Subjects:	Adult Adults Angiofibroma - complications Antibodies, Antineutrophil Cytoplasmic Biopsy Case Report Case reports Coronaviruses COVID-19 Creatinine Embolization Endocarditis Glomerulonephritis - etiology Glomerulonephritis, Membranoproliferative Hematuria Hemodialysis Humans Kidneys Male Microscopy Ostomy Pneumonia Proteins Renal Dialysis Serology Staphylococcus infections Tracheotomy Ultrasonic imaging Urinalysis Urine renal intervention acute renal failure pathology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Crescentic glomerulonephritis is usually associated with an acute nephritic syndrome with rapidly declining renal function. Postinfectious cases usually have a higher possibility of recovery. Juvenile nasopharyngeal angiofibroma (JNA) is a rare, locally aggressive tumour affecting mostly young men. A 28-year-old man presented with recurrent JNA initially excised 2 years prior. The patient was initially managed as a case of airway obstruction and pneumonia. He developed tea-coloured urine, oedema and acute kidney failure requiring dialysis while awaiting surgery. Urine and immunological studies (low C3, negative antineutrophil cytoplasmic antibody and antinucleosomal antibody and high antistreptolysin O) suggested a nephritic aetiology. Nasopharyngeal swab cultures of the mass revealed gram-negative organisms. Kidney biopsy showed diffuse proliferative glomerulonephritis compatible with a postinfectious glomerulonephritis with 77% cellular crescents. The mass was excised with histopathology consistent with JNA. The patient was eventually discharged off dialysis.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1757-790X 1757-790X
DOI:	10.1136/bcr-2021-242785