Search Results - "Naiche, L.A."

Tbx4 and Tbx5 Acting in Connective Tissue Are Required for Limb Muscle and Tendon Patterning by Hasson, Peleg, DeLaurier, April, Bennett, Michael, Grigorieva, Elena, Naiche, L.A., Papaioannou, Virginia E., Mohun, Timothy J., Logan, Malcolm P.O.

“…Proper functioning of the musculoskeletal system requires the precise integration of bones, muscles, and tendons. Complex morphogenetic events ensure that…”
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T-box genes in vertebrate development by Naiche, L A, Harrelson, Zachary, Kelly, Robert G, Papaioannou, Virginia E

“…The myriad developmental roles served by the T-box family of transcription factor genes defy easy categorization. Present in all metazoans, the T-box genes are…”
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Roundabout Receptors Are Critical for Foregut Separation from the Body Wall by Domyan, Eric Thomas, Branchfield, Kelsey, Gibson, Daniel A., Naiche, L.A., Lewandoski, Mark, Tessier-Lavigne, Marc, Ma, Le, Sun, Xin

“…In mammals, precise placement of organs is essential for survival. We show here that inactivation of Roundabout (Robo) receptors 1 and 2 in mice leads to…”
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Identity and fate of Tbx4‐expressing cells reveal developmental cell fate decisions in the allantois, limb, and external genitalia by Naiche, L.A., Arora, Ripla, Kania, Artur, Lewandoski, Mark, Papaioannou, Virginia E.

“…T‐box gene Tbx4 is critical for the formation of the umbilicus and the initiation of the hindlimb. Previous studies show broad expression in the allantois,…”
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Abstract PO015: JAGGED-1 as a novel metastatic extravasation promoter of triple negative breast cancer cells by Gordon, Benjamin, Chaudhri, Reyhaan A., Sargis, Tim, Naiche, L.A., Kitajewski, Jan K.

“…Though survival is improving for breast cancer patients, clinical outcomes remain poor for patients with aggressive molecular subtypes. Triple negative breast…”
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CLIC4 Regulates Endothelial Barrier Control by Mediating PAR1 Signaling via RhoA by Kleinjan, Matthew L., Mao, De Yu, Naiche, L.A., Joshi, Jagdish C., Gupta, Ahana, Jesse, Jordan J., Shaye, Daniel D., Mehta, Dolly, Kitajewski, Jan

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Endothelial Cell Fate Determination: A Top Notch Job in Vascular Decision-Making by Naiche, L A, Villa, Stephanie R, Kitajewski, Jan K

“…As vascular networks form, endothelial cells (ECs) undergo cell fate decisions that determine whether they become tip or stalk cells of the developing vascular…”
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FGF4 and FGF8 comprise the wavefront activity that controls somitogenesis by Naiche, L.A, Holder, Nakisha, Lewandoski, Mark

“…Somites form along the embryonic axis by sequential segmentation from the presomitic mesoderm (PSM) and differentiate into the segmented vertebral column as…”
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CLIC4 Regulates Endothelial Barrier Control by Mediating PAR1 Signaling via RhoA by Kleinjan, Matthew L., Mao, De Yu, Naiche, L.A., Joshi, Jagdish Chandra, Gupta, Ahana, Jesse, Jordan J., Shaye, Daniel D., Mehta, Dolly, Kitajewski, Jan

“…Endothelial CLICs (chloride intracellular channel proteins) CLIC1 and CLIC4 are required for the GPCRs (G-protein-coupled receptors) S1PR1…”
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Neuroblastoma differentiation in vivo excludes cranial tumors by Treffy, Randall W., Rajan, Sriivatsan G., Jiang, Xinghang, Nacke, Lynne M., Malkana, Usama A., Naiche, L.A., Bergey, Dani E., Santana, Dianicha, Rajagopalan, Vinodh, Kitajewski, Jan K., O’Bryan, John P., Saxena, Ankur

“…Neuroblastoma (NB), the most common cancer in the first year of life, presents almost exclusively in the trunk. To understand why an early-onset cancer would…”
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Abstract 3618: The role of endothelial ACKR1 in triple-negative breast cancer metastasis by Roach, Samuel Tanner, Ewenighi-Amankwah, Chinwe, Dufraine, J, Naiche, L.A., Kitajewski, Jan K.

“…Metastasis is the most common cause of breast cancer mortality. Of the breast cancer subtypes, triple-negative breast cancer (TNBC) is the deadliest due to its…”
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Abstract 3207: Notch decoys as potential anti-angiogenic biotherapeutics by Sargis, Timothy, Youn, Seock-Won, Lee, Hyun, Naiche, L.A., Kitajewski, Jan

“…Notch signaling is activated by ligands Delta-like 4 (Dll4) and Jagged1 in the tumor microenvironment to promote tumor angiogenesis and perfusion. Notch…”
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Notch3 signaling promotes tumor cell adhesion and progression in a murine epithelial ovarian cancer model by Price, Jessica C, Azizi, Elham, Naiche, L A, Parvani, Jenny G, Shukla, Priyanka, Kim, Seoyeon, Slack-Davis, Jill K, Pe'er, Dana, Kitajewski, Jan K

“…High grade serous ovarian cancer (HGSC) is the most common and deadly type of ovarian cancer, largely due to difficulties in early diagnosis and rapid…”
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Abstract 247: Targeting Notch4 with a novel neutralizing antibody inhibits tumor growth and alters immune cell populations within the tumor microenvironment by Eng, Jason, Naiche, L.A., Swaminathan, Bhairavi, Kato, Yu, Thakkar, Krishna, Vadakath, Rahul, Herts, James, Emmadi, Rajyasree, Matsui, Junji, Kitajewski, Jan

“…Endothelial Notch signaling is critical for tumor angiogenesis and growth. Inhibition of Notch1 or its ligand, Dll4, can induce tumor vessel hypersprouting,…”
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Abstract LB009: Notch4 inhibition by a novel neutralizing antibody reduces tumor progression and increases macrophage recruitment within the tumor microenvironment by Eng, Jason W., Naiche, L.A., Swaminathan, Bhairavi, Kato, Yu, Thakkar, Krishna, Alexander, Katherine Ann, Vadakath, Rahul, Herts, James H., Emmadi, Rajyasree, Matsui, Junji, Kitajewski, Jan K.

“…The Notch signaling pathway, particularly endothelial Notch signaling, plays a key role in tumor formation and angiogenesis. Inhibiting Notch1 or its ligand,…”
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Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium by Eng, Jason W-L, Kato, Yu, Adachi, Yusuke, Swaminathan, Bhairavi, Naiche, L A, Vadakath, Rahul, Sakamoto, Yoshimasa, Nakazawa, Youya, Tachino, Sho, Ito, Ken, Abe, Takanori, Minoshima, Yukinori, Hoshino-Negishi, Kana, Ogasawara, Hideaki, Kawakatsu, Tomomi, Nishimura, Miyuki, Katayama, Masahiko, Shimizu, Masashi, Tahara, Kazuhiro, Sato, Toshitaka, Suzuki, Katsuhisa, Agarwala, Kishan, Iwata, Masao, Nomoto, Kenichi, Ozawa, Yoichi, Imai, Toshio, Funahashi, Yasuhiro, Matsui, Junji, Kitajewski, Jan

“…Endothelial Notch signaling is critical for tumor angiogenesis. Notch1 blockade can interfere with tumor vessel function but causes tissue hypoxia and…”
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Lineage tracing of Tbx4-expressing cells reveals cryptic developmental decisions by Naiche, L.A., Arora, Ripla, Papaioannou, Virginia, Lewandoski, Mark

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Fibroblast growth factors (FGFs) are required to maintain the presomitic mesoderm by Naiche, L.A., Holder, Nakisha, Lewandoski, Mark B.

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Neuromatous regeneration as a nerve response after catheter-based renal denervation therapy in a large animal model: immunohistochemical study by Rousselle, Serge D, Brants, Irena K, Sakaoka, Atsushi, Hubbard, Brad, Jackson, Nicolette D, Wicks, Joan R, Dillon, Krista N, Naiche, L A, Hart, Randy, Garza, Javier A, Tellez, Armando

“…Renal denervation (RDN) emerged as a therapeutic option for resistant hypertension. Nerve regrowth after RDN has been questioned. We aimed to characterize the…”
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The identity and fate of Tbx4-expressing cells reveal previously unknown developmental decisions in the allantois, limb, and proctodeum by Naiche, L.A., Arora, Ripla, Papaioannou, Virginia E.

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