Search Results - "Nahotko, Dominik"

Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts by Eckert, Mark A., Coscia, Fabian, Chryplewicz, Agnieszka, Chang, Jae Won, Hernandez, Kyle M., Pan, Shawn, Tienda, Samantha M., Nahotko, Dominik A., Li, Gang, Blaženović, Ivana, Lastra, Ricardo R., Curtis, Marion, Yamada, S. Diane, Perets, Ruth, McGregor, Stephanie M., Andrade, Jorge, Fiehn, Oliver, Moellering, Raymond E., Mann, Matthias, Lengyel, Ernst

“…High-grade serous carcinoma has a poor prognosis, owing primarily to its early dissemination throughout the abdominal cavity. Genomic and proteomic approaches…”
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Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis by Kenny, Hilary A, Lal-Nag, Madhu, Shen, Min, Kara, Betul, Nahotko, Dominik A, Wroblewski, Kristen, Fazal, Sarah, Chen, Siquan, Chiang, Chun-Yi, Chen, Yen-Ju, Brimacombe, Kyle R, Marugan, Juan, Ferrer, Marc, Lengyel, Ernst

“…The tumor microenvironment (TME) is a key determinant of metastatic efficiency. We performed a quantitative high-throughput screen (qHTS) of diverse medicinal…”
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Mutant p53 regulates LPA signaling through lysophosphatidic acid phosphatase type 6 by Chryplewicz, Agnieszka, Tienda, Samantha M., Nahotko, Dominik A., Peters, Pamela N., Lengyel, Ernst, Eckert, Mark A.

“…Emerging evidence has indicated that high-grade serous ovarian cancer (HGSOC) originates in the fallopian tube, where the earliest known genetic lesion is the…”
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An engineered ultra‐high affinity Fab‐Protein G pair enables a modular antibody platform with multifunctional capability by Slezak, Tomasz, Bailey, Lucas J., Jaskolowski, Mateusz, Nahotko, Dominik A., Filippova, Ekaterina V., Davydova, Elena K., Kossiakoff, Anthony A.

“…Engineered recombinant antibody‐based reagents are rapidly supplanting traditionally derived antibodies in many cell biological applications. A particularly…”
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Nanoparticle Targeting in Chemo‐Resistant Ovarian Cancer Reveals Dual Axis of Therapeutic Vulnerability Involving Cholesterol Uptake and Cell Redox Balance by Wang, Yinu, Calvert, Andrea E., Cardenas, Horacio, Rink, Jonathon S., Nahotko, Dominik, Qiang, Wenan, Ndukwe, C. Estelle, Chen, Fukai, Keathley, Russell, Zhang, Yaqi, Cheng, Ji‐Xin, Thaxton, C. Shad, Matei, Daniela

“…Platinum (Pt)‐based chemotherapy is the main treatment for ovarian cancer (OC); however, most patients develop Pt resistance (Pt‐R). This work shows that Pt‐R…”
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Non‐apoptotic caspase activation preserves Drosophila intestinal progenitor cells in quiescence by Arthurton, Lewis, Nahotko, Dominik Antoni, Alonso, Jana, Wendler, Franz, Baena‐Lopez, Luis Alberto

“…Caspase malfunction in stem cells often precedes the appearance and progression of multiple types of cancer, including human colorectal cancer. However, the…”
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Abstract A39: Role of LARP1 in the leukemogenesis of Acute Myeloid Leukemia by Nahotko, Dominik A, Baran, Aneta H, Fischietti, Mariafausta, Beauchamp, Elspeth M, Platanias, Leonidas C

“…Abstract Mammalian target of rapamycin (mTOR) is a strong driver of tumorigenesis in multiple types of tumors, however targeting mTOR for cancer therapy has…”
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Abstract NT-097: QUANTITATIVE HIGH-THROUGHPUT SCREENING USING AN ORGANOTYPIC MODEL IDENTIFIES TWO KINASE INHIBITORS THAT INHIBIT OVARIAN CANCER METASTASIS by Kenny, Hilary A., Lal, Madhu, Shen, Min, Nahotko, Dominik, Fazal, Sarah, Chen, Siquan, Chiang, Chun-Yi, Kara, Betul, Yamada, S. Diane, Brimacombe, Kyle, Marugan, Juan, Ferrer, Marc, Lengyel, Ernst

“…Abstract The cancer cells, stromal cells and stroma in the tumor microenvironment contribute to cancer metastasis and drug resistance. Therefore we applied an…”
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Metabolic reprogramming of the stromal epigenome in ovarian cancer metastasis by Eckert, Mark A, Coscia, Fabian, Chryplewicz, Agnieszka A, Chang, Jae Wong, Hernandez, Kyle M, Pan, Shawn, Tienda, Samantha M, Nahotko, Dominik A, Li, Gang, Blaženović, Ivana, Lastra, Ricardo R, Curtis, Marion, Yamada, S. Diane, Perets, Ruth, McGregor, Stephanie, Andrade, Jorge, Fiehn, Oliver, Moellering, Raymond E, Mann, Matthias, Lengyel, Ernst

“…High grade serous ovarian cancer (HGSOC) is characterized by early metastasis throughout the peritoneal cavity and a poor clinical outcome. During the…”
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