Search Results - "Nahar, Kazi"

Stroma-infiltrating T cell spatiotypes define immunotherapy outcomes in adolescent and young adult patients with melanoma by Bai, Xinyu, Attrill, Grace H., Gide, Tuba N., Ferguson, Peter M., Nahar, Kazi J., Shang, Ping, Vergara, Ismael A., Palendira, Umaimainthan, da Silva, Ines Pires, Carlino, Matteo S., Menzies, Alexander M., Long, Georgina V., Scolyer, Richard A., Wilmott, James S., Quek, Camelia

“…The biological underpinnings of therapeutic resistance to immune checkpoint inhibitors (ICI) in adolescent and young adult (AYA) melanoma patients are…”
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New Broad-Spectrum Antibiotics Containing a Pyrrolobenzodiazepine Ring with Activity against Multidrug-Resistant Gram-Negative Bacteria by Picconi, Pietro, Hind, Charlotte K, Nahar, Kazi S, Jamshidi, Shirin, Di Maggio, Lucia, Saeed, Naima, Evans, Bonnie, Solomons, Jessica, Wand, Matthew E, Sutton, J. Mark, Rahman, Khondaker Miraz

“…It is urgent to find new antibiotic classes with activity against multidrug-resistant (MDR) Gram-negative pathogens as the pipeline of antibiotics is…”
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Effects of Systematic Shortening of Noncovalent C8 Side Chain on the Cytotoxicity and NF-κB Inhibitory Capacity of Pyrrolobenzodiazepines (PBDs) by Corcoran, David B, Lewis, Thomas, Nahar, Kazi S, Jamshidi, Shirin, Fegan, Christopher, Pepper, Chris, Thurston, David E, Rahman, Khondaker Miraz

“…The systematic shortening of the noncovalent element of a C8-linked pyrrolobenzodiazepine (PBD) conjugate (13) led to the synthesis of a 19-member library of…”
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Pathological and clinical outcomes following neoadjuvant dual HER2 therapy for early‐stage breast cancer: An Australian institutional real‐world experience by Narayanan, Sathya, Ngui, Nicholas K., Kinchington, Ben, Choi, Joseph Do Woong, Hughes, Thomas Michael D., Rutovitz, Josie, Hasovits, Csilla, Nahar, Kazi J., Edirimanne, Senarath, Marx, Gavin

“…Aim There has been significant progress made in developing novel targeted therapies in the neoadjuvant setting for non‐metastatic HER2‐positive breast cancer,…”
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Higher proportions of CD39+ tumor-resident cytotoxic T cells predict recurrence-free survival in patients with stage III melanoma treated with adjuvant immunotherapy by Attrill, Grace Heloise, Owen, Carina N, Ahmed, Tasnia, Vergara, Ismael A, Colebatch, Andrew J, Conway, Jordan W, Nahar, Kazi J, Thompson, John F, Pires da Silva, Ines, Carlino, Matteo S, Menzies, Alexander M, Lo, Serigne, Palendira, Umaimainthan, Scolyer, Richard A, Long, Georgina V, Wilmott, James S

“…BackgroundAdjuvant immune checkpoint inhibitor (ICI) immunotherapies have significantly reduced the recurrence rate in high-risk patients with stage III…”
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Clinicopathological characteristics and management of colitis with anti-PD1 immunotherapy alone or in combination with ipilimumab by Nahar, Kazi J, Rawson, Robert V, Ahmed, Tasnia, Tattersall, Stephen, Sandanayake, Neomal, Kiely, Christopher J, Lo, Serigne, Carlino, Matteo, Palendira, Umaimainthan, Scolyer, Richard A, Long, Georgina V, Menzies, Alexander M

“…BackgroundColitis is one of the common immune-related adverse events that leads to morbidity and treatment discontinuation of immunotherapy. The clinical…”
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Histological diagnosis of immune checkpoint inhibitor induced acute renal injury in patients with metastatic melanoma: a retrospective case series report by Hultin, Sebastian, Nahar, Kazi, Menzies, Alexander M, Long, Georgina V, Fernando, Suran L, Atkinson, Victoria, Cebon, Jonathan, Wong, Muh Geot

“…Immune checkpoint inhibitors (ICI) have become the standard of care in many oncological conditions but are associated with a spectrum of renal immune-related…”
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Management of infliximab refractory immune checkpoint inhibitor gastrointestinal toxicity: a multicenter case series by Harvey, Catriona, Nahar, Kazi J, McKeown, Janet, Lo, Serigne N, Farag, Sheima, Yousaf, Nadia, Young, Kate, Tas, Liselotte, Meerveld-Eggink, Aafke, Blank, Christian, Thomas, Austin, McQuade, Jennifer, Schilling, Bastian, Johnson, Douglas B, Huertas, Roberto Martín, Arance, Ana, Lee, Joanna, Zimmer, Lisa, Long, Georgina V, Carlino, Matteo S, Wang, Yinghong, Menzies, Alexander Maxwell

“…BackgroundImmune checkpoint inhibitor (ICI) gastrointestinal toxicity (gastritis, enteritis, colitis) is a major cause of morbidity and treatment-related…”
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Noncytotoxic Pyrrolobenzodiazepine–Ciprofloxacin Conjugate with Activity against Mycobacterium tuberculosis by Picconi, Pietro, Jeeves, Rose, Moon, Christopher William, Jamshidi, Shirin, Nahar, Kazi S, Laws, Mark, Bacon, Joanna, Rahman, Khondaker Miraz

“…The development of new antitubercular agents for the treatment of infections caused by multidrug-resistant (MDR) Mycobacterium tuberculosis is an urgent…”
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Distinct pretreatment innate immune landscape and posttreatment T cell responses underlie immunotherapy-induced colitis by Nahar, Kazi J, Marsh-Wakefield, Felix, Rawson, Robert V, Gide, Tuba N, Ferguson, Angela L, Allen, Ruth, Quek, Camelia, da Silva, Ines Pires, Tattersal, Stephen, Kiely, Christopher J, Sandanayake, Neomal, Carlino, Matteo S, McCaughan, Geoff, Wilmott, James S, Scolyer, Richard A, Long, Georgina V, Menzies, Alexander M, Palendira, Umaimainthan

“…Immune-related adverse events represent a major hurdle to the success of immunotherapy. The immunological mechanisms underlying their development and relation…”
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Genomic attributes of Vibrio cholerae O1 responsible for 2022 massive cholera outbreak in Bangladesh by Monir, Md Mamun, Islam, Mohammad Tarequl, Mazumder, Razib, Mondal, Dinesh, Nahar, Kazi Sumaita, Sultana, Marzia, Morita, Masatomo, Ohnishi, Makoto, Huq, Anwar, Watanabe, Haruo, Qadri, Firdausi, Rahman, Mustafizur, Thomson, Nicholas, Seed, Kimberley, Colwell, Rita R., Ahmed, Tahmeed, Alam, Munirul

“…In 2022, one of its worst cholera outbreaks began in Bangladesh and the icddr,b Dhaka hospital treated more than 1300 patients and ca. 42,000 diarrheal cases…”
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C8-Linked Pyrrolobenzodiazepine Monomers with Inverted Building Blocks Show Selective Activity against Multidrug Resistant Gram-Positive Bacteria by Andriollo, Paolo, Hind, Charlotte K, Picconi, Pietro, Nahar, Kazi S, Jamshidi, Shirin, Varsha, Amrit, Clifford, Melanie, Sutton, J. Mark, Rahman, Khondaker Miraz

“…Antimicrobial resistance has become a major global concern. Development of novel antimicrobial agents for the treatment of infections caused by multidrug…”
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Vibrio cholerae O1 associated with recent endemic cholera shows temporal changes in serotype, genotype, and drug-resistance patterns in Bangladesh by Jubyda, Fatema Tuz, Nahar, Kazi Sumaita, Barman, Indrajeet, Johura, Fatema-Tuz, Islam, Mohammad Tarequl, Sultana, Marzia, Ullah, Wali, Tasnim, Jarin, Biswas, Sahitya Ranjan, Monir, Md Mamun, George, Christine Marie, Camilli, Andrew, Ahmed, Niyaz, Ross, Allen G, Clemens, John D, Alam, Munirul

“…Despite the advancement in our understanding of cholera and its etiological agent, Vibrio cholerae, the prevention and treatment of the disease are often…”
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Primary Pericardial Sarcoma with Right Atrial Invasion and Multiple Bilateral Pulmonary Metastases in a Patient with Hereditary Nonpolyposis Colorectal Cancer by Lee, Adrian, Nahar, Kazi, Oh, Lawrence, Wong, Eugene, Clarke, Stephen J.

“…Primary tumours originating from the pericardium are extremely rare. Previous studies have reported that these tumours account for only 6.7–12.8% of all…”
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Triaryl Benzimidazoles as a New Class of Antibacterial Agents against Resistant Pathogenic Microorganisms by Picconi, Pietro, Hind, Charlotte, Jamshidi, Shirin, Nahar, Kazi, Clifford, Melanie, Wand, Matthew E, Sutton, J. Mark, Rahman, Khondaker Miraz

“…A new class of nontoxic triaryl benzimidazole compounds, derived from existing classes of DNA minor groove binders, were designed, synthesized, and evaluated…”
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Tu1243 - Checkpoint Inhibitor Immunotherapy Side-Effects in GI Practice by Sanders, Peter, Sandanayake, Neomal S., Guminski, Alex, Long, Georgina, Menzies, Alex, Nahar, Kazi, Tattersall, Stephen J.

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Abstract 9: Effect of C8-side chain on the cytotoxicity and NF-kB inhibitory capacity of pyrrolobenzodiazepines by Corcoran, David B., Lewis, Thomas, Nahar, Kazi S., Fegan, Christopher, Pepper, Chris, Thurston, David E., Rahman, Khondaker Miraz

“…Abstract Pyrrolobenzodiazepines (PBDs) have long been of interest in chemotherapeutic research as potential clinical agents. Recently, the conjugation of…”
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Abstract A125: Fragment-based approach to develop small-molecule STAT3 transcription factor inhibitors by Nahar, Kazi S., Jamshidi, Shirin, Thurston, David E., Rahman, Khondaker Miraz

“…Abstract Oncogenic transcription factors are an increasingly important target for anticancer therapies, as inhibition could allow the “reprogramming” of tumor…”
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Management of infliximab-refractory immune checkpoint inhibitor gastrointestinal toxicity: A multicenter case series by Harvey, Catriona, Nahar, Kazi Jannatun, Lo, Serigne N., Ahmed, Tasnia, Farag, Sheima, Yousaf, Nadia, Young, Kate, Tas, Liselotte, Meerveld-Eggink, Aafke, Blank, Christian U., Thomas, Austin, McQuade, Jennifer Leigh, Schilling, Bastian, Johnson, Douglas Buckner, Martin Huertas, Roberto, Arance, Ana Maria, Lee, Joanna, Zimmer, Lisa, Long, Georgina V., Menzies, Alexander M.

“…2665 Background: Immune checkpoint inhibitor (ICI) GI tox (gastritis, enteritis, colitis) is a major cause of morbidity and treatment-related death. Guidelines…”
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Fecal Sampling of Soil, Food, Hand, and Surface Samples from Households in Urban Slums of Dhaka, Bangladesh: An Evidence-Based Development of Baby Water, Sanitation, and Hygiene Interventions by Monira, Shirajum, Zohura, Fatema, Bhuyian, Md Sazzadul Islam, Parvin, Tahmina, Barman, Indrajeet, Jubyda, Fatema Tuz, Nahar, Kazi Sumaita, Sultana, Marzia, Ullah, Wali, Biswas, Shwapon Kumar, Hasan, M Tasdik, Rahman, Kazi Zillur, Masud, Jahed, Uddin, Ismat Minhaj, Thomas, Elizabeth D, Perin, Jamie, George, Christine Marie, Alam, Munirul, Johura, Fatema-Tuz

“…The aim of this study was to identify the exposure pathways of fecal pathogens for a pediatric population living in the urban slums of Bangladesh. A total of…”
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