Search Results - "Nagy, Z.K."

Systematic model identification and optimization-based active polymorphic control of crystallization processes by Simone, E., Szilagyi, B., Nagy, Z.K.

“…•A model-based active polymorphic control for batch crystallization is proposed.•A high resolution finite volume method is used to solve population balance…”
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A framework for model reliability and estimability analysis of crystallization processes with multi-impurity multi-dimensional population balance models by Fysikopoulos, D., Benyahia, B., Borsos, A., Nagy, Z.K., Rielly, C.D.

“…•Robust selection of the most influential and least correlated parameters.•Estimability analysis based on sequential orthogonalization and Sobol.•Local and…”
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Downstream processing of polymer-based amorphous solid dispersions to generate tablet formulations by Démuth, B, Nagy, Z K, Balogh, A, Vigh, T, Marosi, G, Verreck, G, Van Assche, I, Brewster, M E

“…Application of amorphous solid dispersions (ASDs) is considered one of the most promising approaches to increase the dissolution rate and extent of…”
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Application of quantitative Raman spectroscopy for the monitoring of polymorphic transformation in crystallization processes using a good calibration practice procedure by Simone, E., Saleemi, A.N., Nagy, Z.K.

“…•Raman spectroscopy used for quantitative monitoring of polymorphic crystallization.•Effects of multiple parameters on Raman spectra were studied.•Calibration…”
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Systematic design of supersaturation controlled crystallization processes for shaping the crystal size distribution using an analytical estimator by Nagy, Z.K., Aamir, E.

“…A novel methodology is presented for the systematic design of setpoint operating curves and seed recipes for supersaturation controlled crystallization…”
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PAT-based design of agrochemical co-crystallization processes: A case-study for the selective crystallization of 1:1 and 3:2 co-crystals of p-toluenesulfonamide/triphenylphosphine oxide by Powell, K.A., Croker, D.M., Rielly, C.D., Nagy, Z.K.

“…In this study, the selective crystallization and characterization of the stoichiometric forms of the p-toluenesulfonamide/triphenylphosphine oxide (p-TSA–TPPO)…”
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Periodic steady-state flow crystallization of a pharmaceutical drug using MSMPR operation by Powell, K.A., Saleemi, A.N., Rielly, C.D., Nagy, Z.K.

“…•Novel concept of periodic mixed suspension mixed product removal (PMSMPR) crystallization process demonstrated.•New concept, referred to as periodic…”
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Detailed stability investigation of amorphous solid dispersions prepared by single-needle and high speed electrospinning by Démuth, B., Farkas, A., Pataki, H., Balogh, A., Szabó, B., Borbás, E., Sóti, P.L., Vigh, T., Kiserdei, É., Farkas, B., Mensch, J., Verreck, G., Van Assche, I., Marosi, G., Nagy, Z.K.

“…[Display omitted] In this research the long-term stability (one year) of amorphous solid dispersions (ASDs) prepared by high speed electrospinning was…”
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Monitoring of the combined cooling and antisolvent crystallisation of mixtures of aminobenzoic acid isomers using ATR-UV/vis spectroscopy and FBRM by Saleemi, A.N., Rielly, C.D., Nagy, Z.K.

“…During the manufacturing of active pharmaceutical ingredients crystalline products in the purest forms are required. Quite often multiple components are…”
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Development and tableting of directly compressible powder from electrospun nanofibrous amorphous solid dispersion by Démuth, B., Farkas, A., Szabó, B., Balogh, A., Nagy, B., Vágó, E., Vigh, T., Tinke, A.P., Kazsu, Z., Demeter, Á., Bertels, J., Mensch, J., Van Dijck, A., Verreck, G., Van Assche, I., Marosi, G., Nagy, Z.K.

“…[Display omitted] •Electrospun nanofibres were successfully tableted from the developed DC powder.•DVS and DSC were applied to study the stability.•Electrospun…”
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Application of fluorescent PIV and digital image analysis to measure turbulence properties of solid–liquid stirred suspensions by Unadkat, H., Rielly, C.D., Hargrave, G.K., Nagy, Z.K.

“…This study describes an experimental technique which combines Fluorescent Particle Image Velocimetry (FPIV) and digital image analysis, to quantify the…”
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Worst-case and distributional robustness analysis of finite-time control trajectories for nonlinear distributed parameter systems by Nagy, Z.K., Braatz, R.D.

“…A novel approach is proposed that quantifies the influence of parameter and control implementation uncertainties upon the states and outputs of finite-time…”
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Local vs Global Estimability Analysis of Population Balance Models for Crystallization Processes by Fysikopoulos, D., Borsos, A., Li, W., Onyemelukwe, I., Benyahia, B., Nagy, Z.K., Rielly, C.D.

“…Estimability and sensitivity analysis has been applied to a one-dimensional population balance model (PBM) that describes the dynamic evolution of the critical…”
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Distributional uncertainty analysis using power series and polynomial chaos expansions by Nagy, Z.K., Braatz, R.D.

“…This paper provides an overview of computationally efficient approaches for quantifying the influence of parameter uncertainties on the states and outputs of…”
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Modelling and control of combined cooling and antisolvent crystallization processes by Nagy, Z.K., Fujiwara, M., Braatz, R.D.

“…Although for decades nearly all pharmaceuticals have been purified by crystallization, there have been a disproportionate number of problems associated with…”
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A high-throughput multi-microfluidic crystal generator (MMicroCryGen) platform for facile screening of polymorphism and crystal morphology for pharmaceutical compounds by Simone, E, McVeigh, J, Reis, N M, Nagy, Z K

“…In this work, a novel multi-microfluidic crystallization platform called MMicroCryGen is presented, offering a facile methodology for generating individual…”
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A study on the effect of the polymeric additive HPMC on morphology and polymorphism of ortho-aminobenzoic acid crystals by Simone, E., Cenzato, M.V., Nagy, Z.K.

“…In the present study, the effect of Hydroxy Propyl Methyl Cellulose (HPMC) on the crystallization of ortho-aminobenzoic acid (OABA) was investigated by seeded…”
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Optimal seed recipe design for crystal size distribution control for batch cooling crystallisation processes by Aamir, E., Nagy, Z.K., Rielly, C.D.

“…The paper presents a novel quality-by-design framework for the design of optimal seed recipes for batch cooling crystallisation systems with the aim to produce…”
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Modelling of mass transfer in gas–liquid stirred tanks agitated by Rushton turbine and CD-6 impeller: A scale-up study by Gimbun, J., Rielly, C.D., Nagy, Z.K.

“…A combined computational fluid dynamics (CFD) and population balance model (PBM) approach has been applied to the simulation of gas–liquid stirred tanks…”
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Integrated twin-screw wet granulation, continuous vibrational fluid drying and milling: A fully continuous powder to granule line by Fülöp, G., Domokos, A., Galata, D., Szabó, E., Gyürkés, M., Szabó, B., Farkas, A., Madarász, L., Démuth, B., Lendér, T., Nagy, T., Kovács-Kiss, D., Van der Gucht, F., Marosi, G., Nagy, Z.K.

“…[Display omitted] Highly homogeneous low-dose (50 μg) tablets were produced incorporating perfectly free-flowing granules prepared by a fully integrated…”
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