Search Results - "Nagy, Janice A"

Anti-VEGF/VEGFR Therapy for Cancer: Reassessing the Target by SITOHY, Basel, NAGY, Janice A, DVORAK, Harold F

“…Judah Folkman recognized that new blood vessel formation is important for tumor growth and proposed antiangiogenesis as a novel approach to cancer therapy…”
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Heterogeneity of the tumor vasculature: the need for new tumor blood vessel type-specific targets by Nagy, Janice A., Dvorak, Harold F.

“…Therapies directed against VEGF-A and its receptors are effective in treating many mouse tumors but have been less so in treating human cancer patients. To…”
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A novel partial gravity ground-based analogue for rats via quadrupedal unloading by Mortreux, Marie, Nagy, Janice A, Ko, Frank C, Bouxsein, Mary L, Rutkove, Seward B

“…Musculoskeletal deconditioning is a well-known consequence of microgravity; however, the effects of partial gravity such as that experienced on the Moon…”
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Novel phenotype characterization utilizing electrical impedance myography signatures in murine spinal cord injury neurogenic bladder models by Wang, Hsin-Hsiao Scott, Thaker, Hatim, Bigger-Allen, Alex, Nagy, Janice A., Rutkove, Seward B.

“…Neurogenic bladder (NB) affects people of all ages. Electric impedance myography (EIM) assesses localized muscle abnormalities. Here, we sought to investigate…”
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VEGF-A and the induction of pathological angiogenesis by Nagy, Janice A, Dvorak, Ann M, Dvorak, Harold F

“…Tumors, wounds, and chronic inflammatory disorders generate a new vascular supply by a process known as pathological angiogenesis. Whereas formation of the…”
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Electrical impedance myography for the early detection of muscle ischemia secondary to compartment syndrome: a study in a rat model by Lechtig, Aron, Hanna, Philip, Nagy, Janice A., Wixted, John, Nazarian, Ara, Rutkove, Seward B.

“…Acute Compartment Syndrome (ACS) is one of the most devastating orthopedic conditions, affecting any of the body’s many compartments, which, if sufficiently…”
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Electrical impedance myography detects age-related skeletal muscle atrophy in adult zebrafish by Rutkove, Seward B., Callegari, Santiago, Concepcion, Holly, Mourey, Tyler, Widrick, Jeffrey, Nagy, Janice A., Nath, Anjali K.

“…Age-related deficits in skeletal muscle function, termed sarcopenia, are due to loss of muscle mass and changes in the intrinsic mechanisms underlying…”
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Electrical impedance myography for the detection of muscle inflammation induced by λ-carrageenan by Mortreux, Marie, Semple, Carson, Riveros, Daniela, Nagy, Janice A, Rutkove, Seward B

“…Electrical impedance myography (EIM) is a technique for the assessment of muscle health and composition and has been shown to be sensitive to a variety of…”
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Assessing the therapeutic impact of resveratrol in ALS SOD1-G93A mice with electrical impedance myography by Nagy, Janice A, Semple, Carson, Lo, PuiChi, Rutkove, Seward B

“…To aid in the identification of new treatments for amyotrophic lateral sclerosis (ALS), convenient biomarkers are needed to effectively and uniformly measure…”
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Altered electrical properties in skeletal muscle of mice with glycogen storage disease type II by Nagy, Janice A., Semple, Carson, Riveros, Daniela, Sanchez, Benjamin, Rutkove, Seward B.

“…Electrical impedance methods, including electrical impedance myography, are increasingly being used as biomarkers of muscle health since they measure passive…”
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Comparison of Quantitative Ultrasound Methods to Classify Dystrophic and Obese Models of Skeletal Muscle by Goryachev, Ivan, Tresansky, Anne Pigula, Ely, Gregory Tsiang, Chrzanowski, Stephen M., Nagy, Janice A., Rutkove, Seward B., Anthony, Brian W.

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Relationships between in vivo surface and ex vivo electrical impedance myography measurements in three different neuromuscular disorder mouse models by Pandeya, Sarbesh R, Nagy, Janice A, Riveros, Daniela, Semple, Carson, Taylor, Rebecca S, Sanchez, Benjamin, Rutkove, Seward B

“…Electrical impedance myography (EIM) using surface techniques has shown promise as a means of diagnosing and tracking disorders affecting muscle and assessing…”
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Antiangiogenic Properties of Gold Nanoparticles by Mukherjee, Priyabrata, Bhattacharya, Resham, Wang, Ping, Wang, Ling, Basu, Sujit, Nagy, Janice A, Atala, Anthony, Mukhopadhyay, Debabrata, Soker, Shay

“…Here, we report an intrinsic property of gold nanoparticles (nanogold): they can interact selectively with heparin-binding glycoproteins and inhibit their…”
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Using Electrical Impedance Myography as a Biomarker of Muscle Deconditioning in Rats Exposed to Micro- and Partial-Gravity Analogs by Semple, Carson, Riveros, Daniela, Sung, Dong-Min, Nagy, Janice A., Rutkove, Seward B., Mortreux, Marie

“…As astronauts prepare to undertake new extra-terrestrial missions, innovative diagnostic tools are needed to better assess muscle deconditioning during periods…”
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Electrical impedance myography detects age-related muscle change in mice by Arnold, W David, Taylor, Rebecca S, Li, Jia, Nagy, Janice A, Sanchez, Benjamin, Rutkove, Seward B

“…Loss of muscle mass and strength represents one of the most significant contributors to impaired function in older adults. Convenient and non-invasive…”
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Tumor-surrogate blood vessel subtypes exhibit differential susceptibility to anti-VEGF therapy by Sitohy, Basel, Nagy, Janice A, Jaminet, Shou-Ching Shih, Dvorak, Harold F

“…Antivascular therapy directed against VEGF or its receptors (VEGFR) has been successful when administered at early stages of tumor vessel growth but is less…”
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Altered muscle electrical tissue properties in a mouse model of premature aging by Clark‐Matott, Joanne, Nagy, Janice A., Sanchez, Benjamin, Taylor, Rebecca, Riveros, Daniela, Abraham, Neeta A., Simon, David K., Rutkove, Seward B.

“…Introduction Improved methods are needed to detect and quantify age‐related muscle change. In this study we assessed the electrical properties of muscle…”
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Partial Weight-Bearing in Female Rats: Proof of Concept in a Martian-Gravity Analog by Semple, Carson, Riveros, Daniela, Nagy, Janice A, Rutkove, Seward B, Mortreux, Marie

“…Many studies have investigated the physiological response to microgravity in both astronauts and animals. However, while space agencies have sought to deploy…”
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Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin by Phung, Thuy L., Ziv, Keren, Dabydeen, Donnette, Eyiah-Mensah, Godfred, Riveros, Marcela, Perruzzi, Carole, Sun, Jingfang, Monahan-Earley, Rita A., Shiojima, Ichiro, Nagy, Janice A., Lin, Michelle I., Walsh, Kenneth, Dvorak, Ann M., Briscoe, David M., Neeman, Michal, Sessa, William C., Dvorak, Harold F., Benjamin, Laura E.

“…Endothelial cells in growing tumors express activated Akt, which when modeled by transgenic endothelial expression of myrAkt1 was sufficient to recapitulate…”
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Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting by Wirzenius, Maria, Tammela, Tuomas, Uutela, Marko, He, Yulong, Odorisio, Teresa, Zambruno, Giovanna, Nagy, Janice A, Dvorak, Harold F, Ylä-Herttuala, Seppo, Shibuya, Masabumi, Alitalo, Kari

“…Lymphatic vessel growth, or lymphangiogenesis, is regulated by vascular endothelial growth factor-C (VEGF-C) and -D via VEGF receptor 3 (VEGFR-3). Recent…”
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