Search Results - "Naguib, Fardos N.M."

Enzymes of pyrimidine salvage pathways in intraerythrocytic Plasmodium falciparum by Naguib, Fardos N.M., Wilson, Craig M., el Kouni, Mahmoud H.

“…Malaria remains a significant public health problem worldwide with an estimated annual global incidence of 200 million and an estimated 450,000 annual deaths…”
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5-phenylthioacyclouridine: a potent and specific inhibitor of uridine phosphorylase by el Kouni, Mahmoud H, Goudgaon, Naganna M, Rafeeq, Mohammad, Al Safarjalani, Omar N, Schinazi, Raymond F, Naguib, Fardos N.M

“…5-Phenylthioacyclouridine (PTAU or 1-[(2-hydroxyethoxy)methyl]-5-phenylthiouracil) was synthesized as a highly specific and potent inhibitor of uridine…”
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Modulation of 5-fluorouracil host toxicity by 5-(benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2′,3′,5′-tri- O-acetyluridine, a prodrug of uridine by Ashour, Osama M, Naguib, Fardos N.M, Panzica, Raymond P, Al Safarjalani, Omar N, el Kouni, Mahmoud H

“…Administration of 200 mg/kg of 5-fluorouracil (FUra) to mice bearing human colon carcinoma DLD-1 xenografts resulted in 100% mortality. Oral administration of…”
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Effect of administration of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on the anti-tumor efficacy of 5-fluoro-2′-deoxyuridine against murine colon tumor C26–10 by Ashour, Osama M, Naguib, Fardos N.M, Goudgaon, Naganna M, Schinazi, Raymond F, el Kouni, Mahmoud H

“…The effect of co-administration of 5-(phenylselenenyl)acyclouridine (PSAU), a new uridine phosphorylase (UrdPase, EC 2.4.2.3) inhibitor, on the efficacy of…”
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Nucleoside kinases in adult Schistosoma mansoni: Phosphorylation of pyrimidine nucleosides by Naguib, Fardos N.M., el Kouni, Mahmoud H.

“…•Adults Schistosoma mansoni contain three nucleoside kinases that can phosphorylate pyrimidine nucleosides.•A non-specific deoxyriboside kinase (EC 2.7.1.145)…”
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Kinetic mechanism of Toxoplasma gondii adenosine kinase and the highly efficient utilization of adenosine by Naguib, Fardos N.M., Rais, Reem H., Al Safarjalani, Omar N., el Kouni, Mahmoud H.

“…Initial velocity and product inhibition studies of Toxoplasma gondii adenosine kinase (TgAK, EC 2.7.1.20) demonstrated that the basic mechanism of this enzyme…”
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Synthesis of [4-(hydroxy)tetrahydrofuran-2-yl]nucleosides as a novel class of uridine phosphorylase inhibitors by Yang, Te-Fang, Kotra, Lakshmi P., Teng, Quincy, Naguib, Fardos N.M., Sommadossi, Jean-Pierre, el Kouni, Mahmoud, Chu, Chung K.

“…[4-(Hydroxy)tetrahydrofuran-2-yl]thymine was synthesized and found to be a potent inhibitor of uridine phosphorylase. [4-(Hydroxy)tetrahydrofuran-2-yl]thymine…”
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Synthesis, biological evaluation and molecular modeling studies of N 6-benzyladenosine analogues as potential anti-toxoplasma agents by Kim, Young Ah, Sharon, Ashoke, Chu, Chung K., Rais, Reem H., Al Safarjalani, Omar N., Naguib, Fardos N.M., el Kouni, Mahmoud H.

“…Toxoplasma gondii is an opportunistic pathogen responsible for toxoplasmosis. T. gondii is a purine auxotroph incapable of de novo purine biosynthesis and…”
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Synthesis, biological evaluation and molecular modeling studies of N-benzyladenosine analogues as potential anti-toxoplasma agents by Kim, Young Ah, Sharon, Ashoke, Chu, Chung K, Rais, Reem H, Safarjalani, Omar N Al, Naguib, Fardos N M, el Kouni, Mahmoud H

“…Toxoplasma gondii is an opportunistic pathogen responsible for toxoplasmosis. T. gondii is a purine auxotroph incapable of de novo purine biosynthesis and…”
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Structure−Activity Relationships of 7-Deaza-6-benzylthioinosine Analogues as Ligands of Toxoplasma gondii Adenosine Kinase by Kim, Young Ah, Sharon, Ashoke, Chu, Chung K, Rais, Reem H, Al Safarjalani, Omar N, Naguib, Fardos N. M, el Kouni, Mahmoud H

“…Several 7-deaza-6-benzylthioinosine analogues with varied substituents on aromatic ring were synthesized and evaluated against Toxoplasma gondii adenosine…”
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Carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase: Biological activities and selective toxicities by Al Safarjalani, Omar N., Rais, Reem H., Kim, Young Ah, Chu, Chung K., Naguib, Fardos N.M., el Kouni, Mahmoud H.

“…Novel carbocyclic 6-benzylthioinosine analogues are subversive substrates of Toxoplasma gondii adenosine kinase and selectively kill the parasites. Toxoplasma…”
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Structure–activity relationships of carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase by Kim, Young Ah, Rawal, Ravindra K., Yoo, Jakyung, Sharon, Ashoke, Jha, Ashok K., Chu, Chung K., Rais, Reem H., Al Safarjalani, Omar N., Naguib, Fardos N.M., el Kouni, Mahmoud H.

“…Carbocyclic 6-benzylthioinosine analogues were synthesized and evaluated for their binding affinity against Toxoplasma gondii adenosine kinase [EC.2.7.1.20]…”
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Potent combination therapy for human breast tumors with high doses of 5-fluorouracil: remission and lack of host toxicity by Al Safarjalani, Omar N., Rais, Reem, Naguib, Fardos N. M., el Kouni, Mahmoud H.

“…Purpose The purpose of this investigation was to evaluate the effectiveness of oral 5-(phenylthio)acyclouridine (PTAU) in reducing 5-fluorouracil (FUra) host…”
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5-(Phenylthio)acyclouridine: a powerful enhancer of oral uridine bioavailability : Relevance to chemotherapy with 5-fluorouracil and other uridine rescue regimens by AL SAFARJALANI, Omar N, ZHOU, Xiao-Jian, RAIS, Reem H, JUNXING SHI, SCHINAZI, Raymond F, NAGUIB, Fardos N. M, EL KOUNI, Mahmoud H

“…The purpose of this investigation was to evaluate the effectiveness of oral 5-(phenylthio)acyclouridine (PTAU) in improving the pharmacokinetics and…”
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7-Deaza-6-benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: Activities and selective toxicities by Al Safarjalani, Omar N., Rais, Reem H., Ah Kim, Young, Chu, Chung K., Naguib, Fardos N.M., el Kouni, Mahmoud H.

“…Toxoplasma gondii adenosine kinase (EC.2.7.1.20) is the major route of adenosine metabolism in this parasite. The enzyme is significantly more active than any…”
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Synthesis, Biological Activity and Molecular Modeling of 6-Benzylthioinosine Analogues as Subversive Substrates of Toxoplasma gondii Adenosine Kinase by YADAV, Vikas, CHU, Chung K., RAIS, Reem H., AL SAFARJALANI, Omar N., GUARCELLO, Vincenzo, NAGUIB, Fardos N. M.

“…Toxoplasma gondii is the most common cause of secondary CNS infections in immunocompromised persons such as AIDS patients. The major route of adenosine…”
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6-Benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: Activities and selective toxicities by Rais, Reem H., Al Safarjalani, Omar N., Yadav, Vikas, Guarcello, Vincenzo, Kirk, Marion, Chu, Chung K., Naguib, Fardos N.M., el Kouni, Mahmoud H.

“…Toxoplasma gondii adenosine kinase (EC.2.7.1.20) is the major route of adenosine metabolism in this parasite. The enzyme is significantly more active than any…”
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Suppression of thymidine phosphorylase expression by promoter methylation in human cancer cells lacking enzyme activity by Guarcello, Vincenzo, Blanquicett, Carmelo, Naguib, Fardos N. M., el Kouni, Mahmoud H.

“…Purpose Thymidine phosphorylase (TP, EC 2.4.2.4) activity varies in different human cancer cell lines. Nevertheless, little is known about the regulatory…”
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6-Benzylthioinosine analogues: Promising anti-toxoplasmic agents as inhibitors of the mammalian nucleoside transporter ENT1 ( es) by Gupte, Amol, Buolamwini, John K., Yadav, Vikas, Chu, Chung K., Naguib, Fardos N.M., el Kouni, Mahmoud H.

“…Certain 6-benzylthioinosine analogues have been identified as potential chemotherapeutic agents against Toxoplasma gondii in cell culture and animal models…”
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Uptake of Nitrobenzylthioinosine and Purine β-l-Nucleosides by Intracellular Toxoplasma gondii by Al Safarjalani, Omar N, Naguib, Fardos N M, El Kouni, Mahmoud H

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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