Search Results - "Naguib, Fardos N. M"

Potent combination therapy for human breast tumors with high doses of 5-fluorouracil: remission and lack of host toxicity by Al Safarjalani, Omar N., Rais, Reem, Naguib, Fardos N. M., el Kouni, Mahmoud H.

“…Purpose The purpose of this investigation was to evaluate the effectiveness of oral 5-(phenylthio)acyclouridine (PTAU) in reducing 5-fluorouracil (FUra) host…”
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Suppression of thymidine phosphorylase expression by promoter methylation in human cancer cells lacking enzyme activity by Guarcello, Vincenzo, Blanquicett, Carmelo, Naguib, Fardos N. M., el Kouni, Mahmoud H.

“…Purpose Thymidine phosphorylase (TP, EC 2.4.2.4) activity varies in different human cancer cell lines. Nevertheless, little is known about the regulatory…”
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Uptake of Nitrobenzylthioinosine and Purine β-l-Nucleosides by Intracellular Toxoplasma gondii by Al Safarjalani, Omar N, Naguib, Fardos N M, El Kouni, Mahmoud H

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Structure−Activity Relationships of 7-Deaza-6-benzylthioinosine Analogues as Ligands of Toxoplasma gondii Adenosine Kinase by Kim, Young Ah, Sharon, Ashoke, Chu, Chung K, Rais, Reem H, Al Safarjalani, Omar N, Naguib, Fardos N. M, el Kouni, Mahmoud H

“…Several 7-deaza-6-benzylthioinosine analogues with varied substituents on aromatic ring were synthesized and evaluated against Toxoplasma gondii adenosine…”
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Carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase: Biological activities and selective toxicities by Al Safarjalani, Omar N., Rais, Reem H., Kim, Young Ah, Chu, Chung K., Naguib, Fardos N.M., el Kouni, Mahmoud H.

“…Novel carbocyclic 6-benzylthioinosine analogues are subversive substrates of Toxoplasma gondii adenosine kinase and selectively kill the parasites. Toxoplasma…”
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5-(Phenylthio)acyclouridine: a powerful enhancer of oral uridine bioavailability : Relevance to chemotherapy with 5-fluorouracil and other uridine rescue regimens by AL SAFARJALANI, Omar N, ZHOU, Xiao-Jian, RAIS, Reem H, JUNXING SHI, SCHINAZI, Raymond F, NAGUIB, Fardos N. M, EL KOUNI, Mahmoud H

“…The purpose of this investigation was to evaluate the effectiveness of oral 5-(phenylthio)acyclouridine (PTAU) in improving the pharmacokinetics and…”
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Synthesis, Biological Activity and Molecular Modeling of 6-Benzylthioinosine Analogues as Subversive Substrates of Toxoplasma gondii Adenosine Kinase by YADAV, Vikas, CHU, Chung K., RAIS, Reem H., AL SAFARJALANI, Omar N., GUARCELLO, Vincenzo, NAGUIB, Fardos N. M.

“…Toxoplasma gondii is the most common cause of secondary CNS infections in immunocompromised persons such as AIDS patients. The major route of adenosine…”
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Enzymes of pyrimidine salvage pathways in intraerythrocytic Plasmodium falciparum by Naguib, Fardos N.M., Wilson, Craig M., el Kouni, Mahmoud H.

“…Malaria remains a significant public health problem worldwide with an estimated annual global incidence of 200 million and an estimated 450,000 annual deaths…”
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7-Deaza-6-benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: Activities and selective toxicities by Al Safarjalani, Omar N., Rais, Reem H., Ah Kim, Young, Chu, Chung K., Naguib, Fardos N.M., el Kouni, Mahmoud H.

“…Toxoplasma gondii adenosine kinase (EC.2.7.1.20) is the major route of adenosine metabolism in this parasite. The enzyme is significantly more active than any…”
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Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor by AL SAFARJALANI, Omar N, RAIS, Reem, JUNXING SHI, SCHINAZI, Raymond F, NAGUIB, Fardos N. M, EL KOUNI, Mahmoud H

“…The purpose of this investigation was to evaluate the effectiveness of oral 5-(phenylthio)acyclouridine (PTAU) in reducing 5-fluorouracil (FUra) host-toxicity…”
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Synthesis, biological evaluation and molecular modeling studies of N6-benzyladenosine analogues as potential anti-toxoplasma agents by YOUNG AH KIM, SHARON, Ashoke, CHU, Chung K, RAIS, Reem H, AL SAFARJALANI, Omar N, NAGUIB, Fardos N. M, EL KOUNI, Mahmoud H

“…Toxoplasma gondii is an opportunistic pathogen responsible for toxoplasmosis. T. gondii is a purine auxotroph incapable of de novo purine biosynthesis and…”
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Nucleoside kinases in adult Schistosoma mansoni: Phosphorylation of pyrimidine nucleosides by Naguib, Fardos N.M., el Kouni, Mahmoud H.

“…•Adults Schistosoma mansoni contain three nucleoside kinases that can phosphorylate pyrimidine nucleosides.•A non-specific deoxyriboside kinase (EC 2.7.1.145)…”
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Kinetic mechanism of Toxoplasma gondii adenosine kinase and the highly efficient utilization of adenosine by Naguib, Fardos N.M., Rais, Reem H., Al Safarjalani, Omar N., el Kouni, Mahmoud H.

“…Initial velocity and product inhibition studies of Toxoplasma gondii adenosine kinase (TgAK, EC 2.7.1.20) demonstrated that the basic mechanism of this enzyme…”
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Metabolism and Selective Toxicity of 6-Nitrobenzylthioinosine in Toxoplasma gondii by EL KOUNI, M. H, GUARCELLO, V, AL SAFARJALANI, O. N, NAGUIB, F. N. M

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Phenylselenenyl- and phenylthio-substituted pyrimidines as inhibitors of dihydrouracil dehydrogenase and uridine phosphorylase by Goudgaon, Naganna M, Naguib, Fardos N. M, el Kouni, Mahmoud H, Schinazi, Raymond F

“…Lithiation of 5-bromo-2,4-bis(benzyloxy)pyrimidine (3) with n-BuLi at -80 degrees C followed by the addition of diphenyl diselenide or diphenyl disulfide as an…”
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Structure–activity relationships of carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase by Kim, Young Ah, Rawal, Ravindra K., Yoo, Jakyung, Sharon, Ashoke, Jha, Ashok K., Chu, Chung K., Rais, Reem H., Al Safarjalani, Omar N., Naguib, Fardos N.M., el Kouni, Mahmoud H.

“…Carbocyclic 6-benzylthioinosine analogues were synthesized and evaluated for their binding affinity against Toxoplasma gondii adenosine kinase [EC.2.7.1.20]…”
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6-Benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: Activities and selective toxicities by Rais, Reem H., Al Safarjalani, Omar N., Yadav, Vikas, Guarcello, Vincenzo, Kirk, Marion, Chu, Chung K., Naguib, Fardos N.M., el Kouni, Mahmoud H.

“…Toxoplasma gondii adenosine kinase (EC.2.7.1.20) is the major route of adenosine metabolism in this parasite. The enzyme is significantly more active than any…”
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6-Benzylthioinosine analogues: Promising anti-toxoplasmic agents as inhibitors of the mammalian nucleoside transporter ENT1 ( es) by Gupte, Amol, Buolamwini, John K., Yadav, Vikas, Chu, Chung K., Naguib, Fardos N.M., el Kouni, Mahmoud H.

“…Certain 6-benzylthioinosine analogues have been identified as potential chemotherapeutic agents against Toxoplasma gondii in cell culture and animal models…”
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Synthesis, Biological Activity and Molecular Modeling of 6-Benzylthioinosine Analogues as Subversive Substrates of Toxoplasma g ondii Adenosine Kinase by Yadav, Vikas, Chu, Chung K, Rais, Reem H, Al Safarjalani, Omar N, Guarcello, Vincenzo, Naguib, Fardos N. M

“…Toxoplasma gondii is the most common cause of secondary CNS infections in immunocompromised persons such as AIDS patients. The major route of adenosine…”
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Synthesis, biological evaluation and molecular modeling studies of N 6-benzyladenosine analogues as potential anti-toxoplasma agents by Kim, Young Ah, Sharon, Ashoke, Chu, Chung K., Rais, Reem H., Al Safarjalani, Omar N., Naguib, Fardos N.M., el Kouni, Mahmoud H.

“…Toxoplasma gondii is an opportunistic pathogen responsible for toxoplasmosis. T. gondii is a purine auxotroph incapable of de novo purine biosynthesis and…”
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